2-bromo-5-(tert-butyl)-thiophene

2-% hydroxyl-5- (furanyl) uracil, a derivative of uracil. The physical properties are as follows:
Its appearance is usually white to light yellow crystalline powder, which is relatively stable at room temperature and pressure. From the melting point, it is about 200-210 ° C, and the phase transition will occur at this temperature.
In terms of solubility, it is slightly soluble in water, because its molecular structure contains some groups that can form hydrogen bonds with water molecules, such as hydroxyl groups, but the hydrophobic part of the whole molecule also affects its solubility in water. However, it is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), because these organic solvents can interact with the molecules of the substance through van der Waals forces, etc., so as to achieve dissolution.
In terms of chemical stability, it has a certain tolerance to the general weak acid-base environment, but under strong acid and alkali conditions, some chemical bonds in its molecular structure, such as the chemical bonds between the furan ring and the pyrimidine ring, may break or rearrange.
In terms of spectral properties, there is a characteristic absorption peak in the ultraviolet region, which is mainly due to the conjugated double bond structure existing in the molecule, such as the large conjugated system composed of pyrimidine ring and furan ring, which makes it capable of absorbing ultraviolet light of specific wavelengths, and can be qualitatively and quantitatively analyzed by ultraviolet spectroscopy.
In its crystal structure, the molecules form a certain accumulation mode through weak interactions such as hydrogen bonds, which also affects its macroscopic physical properties, such as hardness, density, etc. The density is about [X] g/cm ³, which is within a certain range among similar organic compounds.

2-% hydrazine-5- (tert-butyl) pyrimidine is an organic compound, which has the following chemical properties:
1. ** Basic **: The hydrazine group contains nitrogen atoms, has lone pairs of electrons, can capture protons from acids or water, and is alkaline. Take the reaction with hydrochloric acid as an example, it will generate corresponding salts. This property allows the compound to form salts in acidic environments and improve its solubility. In organic synthesis, this property can be used to separate or purify the substance.
2. ** Nucleophilic **: The lone pair electrons on the nitrogen atom make the hydrazine group nucleophilic, making it easy to attack the electrophilic reagents. If it encounters halogenated hydrocarbons, a nucleophilic substitution reaction can occur. Nitrogen atoms attack halogenated hydrocarbons and connect to halogens. Halogens leave to form new carbon-nitrogen bonds. This reaction can modify the structure of the compound, introduce different substituents, and expand its application in organic synthesis.
3. ** Reductivity **: The electron cloud density of the nitrogen-nitrogen single bond in the hydrazine group is high, and it is easy to be oxidized, showing reducing properties. In specific chemical reactions, it can act as a reducing agent to provide electrons for other substances, and itself is oxidized. For example, redox reactions occur with certain metal ions to reduce metal ions to low-priced states or metal elementals. This reduction is useful in some reactions that require the reduction of specific functional groups.
4. ** Stability of pyrimidine ring **: The pyrimidine ring is a six-membered nitrogen-containing heterocycle with certain aromaticity, which makes the structure of the whole compound relatively stable. However, the nitrogen atom on the ring can participate in various reactions, such as electrophilic substitution reaction with electrophilic reagents. Due to the electronegativity of nitrogen atoms, the electron cloud of the pyrimidine ring is unevenly distributed, and specific positions are more susceptible to electrophilic attack. This property can be exploited in organic synthesis to purposefully introduce substituents on the pyrimidine ring to prepare a variety of derivatives.
5. ** Effect of substituents **: The tert-butyl group at position 5 is a larger sterically hindered substituent, which will affect the physical and chemical properties of the compound. The steric hindrance effect will interfere with the interaction between molecules and affect the physical properties such as solubility, melting point and boiling point of compounds. At the same time, in chemical reactions, due to tert-butyl space hindrance, it is more difficult for the reactants to approach the reaction check point, which changes the reaction selectivity and affects the reaction rate and product distribution.

2-% -5- (tert-butyl) pyridine, its main use. This compound is used in many fields of synthesis. In manufacturing, it can be used as an important medium for the synthesis of many molecules with specific biological activities. For example, in some new studies for the treatment of cardiovascular diseases, 2-% -5- (tert-butyl) pyridine plays a role in its synthesis pathway. It can cleverly build the core of the molecule through a series of reactions, so that the compound has the ability to act on the target of cardiovascular disease.
In the field of materials science, 2-% -5- (tert-butyl) pyridine also has its application. It can be used to synthesize materials with special properties, such as materials with optical properties. It is introduced into the material molecules and can change the light absorption and emission characteristics of the material. It is very important to manufacture optical devices such as optical diodes (OLEDs), which can improve the optical efficiency and chromaticity of the device, and improve the performance of the phase.
In addition, in the chemical catalytic domain, 2-% -5- (tert-butyl) pyridine can be used to form complexes, which form a high-efficiency catalytic system. This catalyst exhibits excellent catalytic activity in the synthesis of polymorphism. For example, in the formation of carbon-carbon polymorphism, it can effectively promote the reaction of polymorphism, and make the polymorphism more effective. It produces fewer side-reactions and improves the efficiency of chemical synthesis. In addition, 2-% -5- (tert-butyl) pyridine, with its unique molecules, plays an indispensable role in the field of polymorphism.

To prepare 2-hydroxy-5- (tert-butyl) acetophenone, there are many ways to synthesize it, and several are listed below.
First, it can be started from the corresponding phenols. Using p-tert-butyl phenol as raw material, the acylation reaction is first carried out. Acetyl chloride or acetic anhydride can be selected, and the reaction is carried out in a suitable organic solvent such as dichloromethane under the catalysis of Lewis acid such as anhydrous aluminum trichloride. In this reaction, the ortho or para-site of the phenolic hydroxyl group is attacked by electrophilic reagents. After considering the electron cloud density distribution and steric resistance, acetyl groups are introduced into the ortho-site of the phenolic hydroxyl group to obtain the target product 2-hydroxy-5- (tert-butyl) acetophenone. When reacting, it is necessary to pay attention to the control of the reaction temperature and time. If the temperature is too high or the time is too long, or side reactions occur, such as the formation of polyacylation products.
Second, halogenated aromatics are used as starting materials. Select suitable halogenated p-tert-butylbenzene, such as p-tert-butylbromobenzene, and make Grignard reagent first. React it with acetyl reagents, such as ethyl acetate, in anhydrous ether or tetrahydrofuran and other solvents. Grignard reagents undergo nucleophilic addition to ester carbonyl, and the target product can be obtained after hydrolysis. In this process, the preparation of Grignard reagents requires strict anhydrous and anaerobic conditions, otherwise it is easy to fail, and the hydrolysis step needs to be properly controlled to ensure
Third, the extended path of Friedel-Crafts reaction can be borrowed. Using p-tert-butylbenzene and acetic anhydride as raw materials, catalyzed by a special catalyst, under specific reaction conditions. This catalyst is either a modified Lewis acid or a solid acid catalyst with a specific structure, which can improve the selectivity and efficiency of the reaction. At the same time, the reaction solvent, reaction temperature, pressure and other parameters are optimized to make the reaction more advantageous, and 2-hydroxy- 5 - (tert-butyl) acetophenone is generated with high selectivity.

In the storage of 2-% -5- (furyl) uracil, the following general things should be paid attention to.
First, the control of the degree is of paramount importance. The property of this compound may be degraded due to the degree of wave, and it is easy to decompose or accelerate the reverse process. Therefore, it is appropriate to store it in the same place and the degree of temperature is determined. Generally, refrigerated parts should be refrigerated at 2-8 ° C to maintain their quality.
Secondly, the degree of temperature should not be ignored. 2-% -5- (furyl) uracil has a certain water absorption, and the moisture environment may cause its absorption, which affects the degree of temperature. Therefore, if it needs to be stored in a dry place, it can be used to reduce the severity of the surrounding environment.
Furthermore, light is also a major factor. This compound is sensitive to light, and exposure to light may cause photochemical reactions, causing changes or reduced activity. Therefore, if it is not stored or damaged, it is necessary to avoid direct exposure to light or light. It is advisable to use a light-shielding material to wrap or store it in an opaque container.
In addition, 2-% -5- (furyl) uracil may have certain toxicity and irritation. During operation and operation, preventive measures must be taken. Workers should wear appropriate protective clothing, gloves and eyewear to prevent contact with skin or eyes. In the process of

, it is also necessary to follow the instructions of the phase of dangerous products and properly pack them to prevent leakage.
During the process, it is necessary to pay attention to avoid collision due to strong shock. The strong shock may cause the container to be damaged, increase leakage, and may cause physical damage to the compound. Therefore, the tools should be well-balanced and fixed.