2-bromo-5-iodothiophene

2-Bromo-5-iodothiophene is one of the organic compounds. It is active and plays an important role in many organic reactions.
The reactivity of this compound originates from the diatoms of bromine and iodine in its molecular structure. Both bromine and iodine are halogen elements with strong electronegativity, resulting in the polarity of the carbon-halogen bond. This polarity makes the electron cloud of the carbon-halogen bond biased towards the halogen atom, making the carbon atom connected to the halogen atom partially positive and vulnerable to attack by nucleophiles.
In the nucleophilic substitution reaction, the bromine or iodine atom in 2-bromo-5-iodothiophene can be replaced by other nucleophilic groups. For example, with alkoxy as the nucleophilic reagent, under appropriate conditions, the bromine or iodine atom can be replaced by alkoxy to generate corresponding ether compounds. This reaction needs to be carried out in an alkaline environment, and the base can promote the formation of nucleophilic reagents and the smooth progress of the reaction.
In addition, in metal-catalyzed reactions, such as palladium-catalyzed cross-coupling reactions, 2-bromo-5-iodothiophene is also a common substrate. Under the combined action of palladium catalyst, ligand and base, it can be coupled with metal-organic reagents containing boron and zinc to form carbon-carbon bonds, which is of great significance in the synthesis of complex organic molecules. It can be used to prepare organic materials with specific structures and functions, pharmaceutical intermediates, etc.
Furthermore, 2-bromo-5-iodothiophene has certain aromaticity due to the existence of thiophene ring. However, the substitution of bromine and iodine on the thiophene ring has a slight impact on its electron cloud distribution and aromaticity. This effect or its chemical properties are different from those of the thiophene parent, such as reactivity and selectivity.
In addition, its physical properties are also closely related to the structure. Due to the introduction of bromine and iodine atoms, the intermolecular force is enhanced, resulting in higher boiling and melting points than thiophene. And due to the presence of halogen atoms, its solubility is also different from that of thiophene, and its solubility may change in polar organic solvents.
In short, 2-bromo-5-iodothiophene exhibits active chemical properties due to its unique chemical structure. It is widely used in the field of organic synthesis and provides an important path for the preparation of many organic compounds.

The synthesis methods of 2-bromo-5-iodothiophene have existed in ancient times, and there are many kinds. The common method is the halogenation reaction. Among them, bromination and iodization are applied successively, which are quite commonly used.
First take thiophene as the base, and use an appropriate brominating agent, such as bromine ($Br_2 $). Under suitable reaction conditions, such as low temperature and the presence of a catalyst, the specific position of thiophene is brominated to obtain 2-bromothiophene. This catalyst is commonly used in Lewis acids, such as iron tribromide ($FeBr_3 $), which can promote the polarization of bromine molecules and accelerate the reaction. Then, 2-bromothiophene is treated with an iodizing agent, such as a combination of potassium iodide ($KI $) and hydrogen peroxide ($H_2O_2 $), and reacted in a suitable solvent, iodine atoms can be introduced to obtain 2-bromo-5-iodothiophene. In this process, hydrogen peroxide acts as an oxidizing agent to promote the conversion of iodine ions into active iodine species and achieve iodization.
Another metal-catalyzed coupling reaction method. Using a metal catalyst such as palladium ($Pd $), with suitable ligands, the bromine-containing and iodine-containing substrates are coupled under basic conditions. For example, 2-bromothiophene borate and iodine aromatics can be coupled to obtain the target product under the action of palladium catalyst. This method requires precise control of reaction conditions, including temperature, type and dosage of bases, ratio of catalysts and ligands, etc., to improve yield and selectivity.
In addition, there is a step-by-step construction method based on thiophene derivatives. Starting from simple thiophene derivatives, bromine and iodine atoms are gradually introduced through multi-step reactions such as substitution, addition, redox, etc., and finally 2-bromo-5-iodothiophene is synthesized. Although this approach has many steps, the reaction sequence and conditions can be flexibly adjusted to adapt to different needs and optimize the synthesis route.
All synthetic methods have their own advantages and disadvantages. In practical application, the selection should be weighed according to factors such as the availability of raw materials, cost, difficulty of reaction conditions and product purity.

2-Bromo-5-iodothiophene is an organic compound that has applications in many fields.
In the field of organic synthesis, it is often used as a key intermediate. Due to its high reactivity of bromine and iodine atoms in the molecule, it can form carbon-carbon bonds and carbon-heteroatom bonds through many reactions, such as Suzuki coupling reaction, Stille coupling reaction, etc., with different organometallic reagents or nucleophiles, and then synthesize complex organic molecules, such as functionalized thiophene derivatives, which are of great significance in the field of materials science.
In the field of materials science, 2-bromo-5-iodothiophene polymers or oligomers prepared by a series of reactions exhibit excellent photoelectric properties. It can be used to prepare organic Light Emitting Diodes (OLEDs). OLEDs have the advantages of self-luminescence, wide viewing angle and fast response speed, and are widely used in the display field. It can also be used to prepare organic solar cells (Offics), which can help the development of renewable energy.
In the field of medicinal chemistry, 2-bromo-5-iodothiophene or its derived structures can be used as lead compounds for structural modification and optimization. The thiophene ring structure widely exists in many bioactive natural products and drug molecules. The bromine and iodine atoms of this compound can participate in the design of drug molecules to adjust the physicochemical properties, biological activities and pharmacokinetic properties of molecules, or to develop drugs with novel mechanisms of action.
In the field of fine chemistry, 2-bromo-5-iodothiophene can be used to synthesize fine chemicals with special functions, such as high-performance dyes, fragrance additives, etc. Its unique chemical structure may endow these fine chemicals with special color, odor or other functional properties, meeting the needs of different industries for special chemicals.

2-Bromo-5-iodothiophene is an organic compound that is quite useful in the field of chemical synthesis. However, its market price often fluctuates due to various factors, which is difficult to say exactly.
First, the supply and demand situation has a deep impact on its price. If the market has strong demand for 2-bromo-5-iodothiophene and the supply is relatively scarce, the price will rise; conversely, if the market demand is low and the supply is sufficient, the price will easily fall.
Second, the cost of raw materials is also the key. This compound synthesis requires specific raw materials, and fluctuations in raw material prices will directly affect the price of 2-bromo-5-iodothiophene. If the supply of raw materials is tight or the production cost increases, the price of the product will increase accordingly.
Third, the production process is closely related to the technical level. Advanced and efficient production processes can reduce production costs. If enterprises can use advanced technologies to improve production efficiency, reduce energy consumption and waste, the product may have a better price in the market.
Fourth, the market competition situation should not be underestimated. When there are many market participants and the competition is fierce, enterprises may win by price strategy in order to compete for share, resulting in lower prices; while when the market is monopolized or the competition is insufficient, the price may be relatively high.
Fifth, the macroeconomic situation and the impact of policies and regulations cannot be ignored. When the economy is prosperous, market demand increases, and prices may rise; otherwise, they will fall. At the same time, changes in policies and regulations such as environmental protection may increase the production cost of enterprises, driving up product prices.
To know the exact market price of 2-bromo-5-iodothiophene, you need to pay attention to the chemical product trading platform, industry information and inquire from relevant suppliers in real time to obtain accurate price information.

2-Bromo-5-iodothiophene is an organic compound, and its storage conditions are crucial to the stability and safety of the substance. According to the theory of "Tiangong Kaiwu" and current scientific understanding, the details are as follows:
First, it must be placed in a cool place. This compound is quite sensitive to heat, and high temperature can easily cause decomposition or chemical reactions. If heated, the activity or enhancement of bromine and iodine atoms can cause molecular structure changes. In a cool place, the temperature is stable and low, which can keep its chemical properties stable, just as the ancients hid things in a cool cellar to prevent their deterioration.
Second, it should be in a dry environment. Moisture can cause many chemical reactions. 2-bromo-5-iodothiophene encounters water, or hydrolyzes, or reacts with other substances involved in water. Therefore, the storage place needs to be dry and free of moisture, just like the storage of ancient times. A dry place must be selected to avoid moisture and prevent spoilage.
Third, it should be stored in a sealed container. This compound is exposed to air or reacts with gases such as oxygen and carbon dioxide. A sealed container can prevent the intrusion of external gases and maintain the stability of the internal environment. It is similar to the ancient people who sealed the contents with pottery pots to ensure its quality.
Fourth, keep away from fire sources and oxidants. 2-Bromo-5-iodothiophene may be flammable and reacts violently to oxidizing agents, causing danger. Just as the ancients prevented fire, keep away from fire sources and fire-prone objects in storage.
In summary, 2-bromo-5-iodothiophene should be stored in a cool, dry, sealed container, and away from fire sources and oxidizing agents. This is essential to ensure its stability and safety.