2-Bromo-5-formylthiophene

2-Bromo-5-formylthiophene is a kind of organic compound. Its molecule contains both bromine atom and formyl group, attached to the thiophene ring. This structure gives it unique chemical properties.
Let's talk about formyl first, which has strong electrophilicity and can participate in many reactions. First, nucleophilic addition reactions can be carried out. For example, in the case of nucleophiles containing active hydrogen, such as alcohols, under suitable conditions, the carbonyl carbon of the formyl group will combine with the oxygen atom of the alcohol, and the active hydrogen will be added to the carbonyl oxygen to form hemiacetal or acetal products. Second, the formyl group can undergo an oxidation reaction, and under the action of a suitable oxidant, it can be converted into a carboxyl group, which can then generate 2-bromo-5-thiophenecarboxylic acid. Third, in a specific basic environment and the presence of a matching reactant, the formyl group can participate in reactions such as hydroxyaldehyde condensation, thereby prolonging the carbon chain and building a more complex organic structure.
Looking at the bromine atom, it is a good leaving group, so that the compound can undergo nucleophilic substitution reactions. When there is a nucleophilic reagent, the nucleophilic reagent will attack the carbon atom attached to the bromine, and the bromine atom will leave with a pair of electrons, and the nucleophilic reagent will For example, when reacting with sodium alcohol, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds. At the same time, bromine atoms can participate in coupling reactions under metal catalysis conditions, such as carbon-carbon bond coupling with another organic compound containing unsaturated bonds under the action of metal catalysts such as palladium, to achieve molecular structure expansion and modification.
In addition, thiophene rings themselves have certain aromatic properties, which contribute to the stability of the whole molecule and affect the reactivity of the substituents. Under different reaction conditions, the structure of 2-bromo-5-formylthiophene interacts with each other, exhibiting diverse chemical reaction properties. It is widely used in the field of organic synthesis and can be used as a key intermediate to prepare various functional organic materials, drugs and natural products.

To prepare 2-bromo-5-formylthiophene, there are two methods. First, thiophene is used as the starting point, first formylated and then brominated. During formylation, thiophene is co-heated with DMF and POCl to obtain 5-formylthiophene. In this step, temperature control and suitable solvent selection are required to increase the yield. After liquid bromine or N-bromosuccinimide (NBS) as the bromine source, brominated in an inert gas environment and at a suitable temperature, the target product can be obtained. The advantage of this approach is that the steps are clear, the formyl localization effect can introduce bromine to the 5-position; its lack, the formylation and bromination conditions may be severe, and the side reactions may be raw.
Second, first bromide thiophene to obtain 2-bromothiophene, and then carry out formylation. Bromination is often catalyzed by liquid bromine and iron bromide to generate 2-bromothiophene. During formylation, hydrogen is pulled out with n-butyl lithium, followed by DMF to obtain 2-bromo-5-formylthiophene. The advantages of this approach are that bromination is easy to control, and the formylation step is selective; its disadvantages are that n-butyllithium is active, the operation needs to be anhydrous and anaerobic, and the cost may be high. In short, the two methods have their own advantages and disadvantages. When implementing the system, it should be selected according to factors such as raw materials, equipment, cost and yield.

2-Bromo-5-formylthiophene, this substance has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can participate in many organic reactions, and through specific reaction pathways, it can build complex organic molecules with diverse structures.
In the field of pharmaceutical chemistry, it is used as a starting material, through various chemical transformations, or compounds with specific biological activities can be prepared, laying the foundation for the development of new drugs. Because of its unique structure of thiophene ring and bromine and formyl group, it endows the molecule with unique chemical and physical properties, which can precisely interact with targets in organisms, or exhibit biological activities such as antibacterial, anti-inflammatory, and anti-tumor, providing the possibility for the creation of new drugs.
In the field of materials science, it also has important applications. It can be chemically modified to introduce it into the structure of polymer materials to improve the photoelectric properties of materials. For example, in the preparation of organic Light Emitting Diode (OLED) materials, its structural characteristics are used to optimize the luminous efficiency and stability of materials and improve device performance; in solar cell materials, its unique electronic structure may help improve the photoelectric conversion efficiency of batteries.
In addition, in the synthesis of fine chemical products, 2-bromo-5-formylthiophene is often an important raw material for the synthesis of high-value-added fine chemicals, such as special fragrances, dyes, etc., giving the product unique properties and quality.

2-Bromo-5-formylthiophene is a chemical substance, and many things should be paid attention to when storing and transporting.
First words storage. This material is very lively and should be stored in a cool, dry and well ventilated place. Avoid open flames and hot topics to prevent danger. Because of its sensitivity to air, light or sensitivity, it should be sealed and stored, and it is best placed in a brown bottle to block the influence of light. Temperature must also be strictly controlled. If it is too high, it is easy to decompose or deteriorate. It is usually appropriate to refrigerate at low temperature, but it should also be avoided from solidification and affecting the use.
Times and transportation. When transporting, make sure that the packaging is intact. The container must be sturdy and able to withstand certain pressure and vibration to prevent leakage. Because it may be toxic or irritating, transportation personnel should have professional protection, wearing protective clothing, protective gloves and masks, etc. Transportation vehicles should also choose suitable ones, stay away from fire and heat sources, and follow relevant transportation regulations, plan routes reasonably, and avoid crowded and environmentally sensitive places.
Furthermore, whether it is storage or transportation, it is necessary to have a detailed understanding of the characteristics of 2-bromo-5-formylthiophene. In case of emergency, there should be corresponding countermeasures, such as cleaning methods in the event of leakage, first aid measures after personnel contact, etc., to ensure the safety of personnel and the environment from pollution.

2 - Bromo - 5 - formylthiophene is an important intermediate in organic synthesis, which is widely used in medicine, pesticides, materials science and other fields. However, its market price is difficult to determine with certainty, because many factors will affect it.
The first to bear the brunt is the market supply and demand relationship. If the demand for this compound is strong and the supply is limited, its price will rise; conversely, if the market is oversupplied, the price will tend to fall. Furthermore, production costs are also a key factor. The cost of raw materials, the complexity of the synthesis process, the energy consumption and equipment required in the production process, etc., will all have an impact on the final price. If the raw materials are rare and expensive, or the synthesis process is cumbersome, high-end equipment and fine operation are required, the cost will be high, and the price will rise.
In addition, product quality and purity also have a great impact on the price. High purity 2 - Bromo - 5 - formylthiophene is more popular in application scenarios with strict purity requirements, and its price is often higher than that of low purity. Different manufacturers have different product prices due to differences in technology and quality control levels. Well-known large factories have high prices due to their high-quality products and good reputation; while some small factories have lower prices, but the quality may not be guaranteed.
Regional factors cannot be ignored. Prices will fluctuate in different regions due to differences in economic development levels, logistics costs, tax policies, etc. Economically developed regions may have relatively high prices due to high operating costs; while places with convenient logistics may have certain advantages due to low transportation costs.
To sum up, the market price of 2-Bromo-5-formylthiophene may range from a few to tens of yuan per gram. The specific price needs to comprehensively consider the above factors and will continue to change with market dynamics. When purchasing, multiple comparisons are required to obtain suitable prices and high-quality products.