2-Bromo-5-ethynylthiophene

2-Bromo-5-ethynylthiophene is also an organic compound. It has a wide range of uses and is often a key raw material in the field of organic synthesis.
Geiinthiophene ring has a unique electronic structure and reactivity, and the introduction of bromine atoms and ethynyl groups adds to the diversity of its reactions. In materials science, based on this, photoelectric materials with specific properties can be prepared. If you want to create organic semiconductors with efficient charge transport properties, 2-bromo-5-ethynylthiophene can be a building unit. After a specific chemical reaction, it is polymerized into a chain or network structure, giving the material excellent electrical conductivity and optical properties.
Furthermore, in the field of medicinal chemistry, it also has potential applications. By modifying the substituents on the thiophene ring, the physicochemical properties and biological activities of the compound can be adjusted. Using it as a starting material, through multi-step reactions, molecules with specific pharmacological activities may be prepared for the treatment and prevention of diseases.
In addition, in the field of fine chemistry, 2-bromo-5-ethynylthiophene can be used to synthesize special fragrances, pigments and additives. After ingenious chemical transformation, the product is endowed with unique aroma, color or other excellent properties to meet the needs of different industries. In conclusion, 2-bromo-5-ethynylthiophene, with its unique structure, has shown important application value in many fields such as organic synthesis, materials science, medicinal chemistry, and fine chemistry, providing a rich material basis and research direction for the development of various fields.

2-Bromo-5-ethynylthiophene is an organic compound with special physical properties. Let me describe it in detail for you.
First of all, under normal temperature and pressure, 2-bromo-5-ethynylthiophene is usually in a colorless to light yellow liquid state. This state makes it exist in an ordinary environment in the form of a liquid, flowing freely, and has a certain degree of transparency. However, due to impurities or preparation processes, it may be slightly yellow.
Describe its boiling point twice. Due to the interaction between bromine atoms and ethynyl and thiophene rings in the molecular structure, its boiling point is about 100-110 ° C/1.5 mmHg (under different experimental conditions or slight differences). This boiling point value shows that under specific pressure conditions, heated to this temperature range, the compound will change from liquid to gaseous state, showing the characteristics of material state change.
Furthermore, its melting point is also an important physical property. After determination, the melting point of 2-bromo-5-ethynylthiophene is about -15 ° C. At this temperature, the substance will solidify from liquid to solid state, and the arrangement of molecules tends to be orderly, reflecting the characteristics of solid matter.
The density of 2-bromo-5-ethynylthiophene is about 1.64 g/cm ³. This density means that the mass of the compound per unit volume is slightly higher than that of common organic solvents. If mixed with water, because its density is higher than that of water, it will sink to the bottom of the water, which can be distinguished by this characteristic in liquid-liquid separation and other operations.
In terms of solubility, 2-bromo-5-ethynylthiophene is soluble in common organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc. Due to the similar miscibility between the molecular structure and the organic solvent, the solubility in water is not good. Because it is an organic compound, the polarity difference with water is large, and it is difficult to form an effective interaction with water molecules.
2-Bromo-5-ethynylthiophene under certain conditions, due to the conjugation system of thiophene ring, the activity of bromine atom and the unsaturation of ethynyl group, or showing certain chemical activity, triggers various chemical reactions. Although this is not a physical property, it is related to the physical properties, which affects its performance in practical application and storage.

The synthesis of 2-bromo-5-ethynylthiophene is a key issue in the field of organic synthesis. Its synthesis method often follows several common paths.
One of them can be initiated by halogenation reaction. First, thiophene is taken as the substrate, and a suitable brominating agent, such as bromine or N-bromosuccinimide (NBS), is introduced into the thiophene ring under suitable reaction conditions to obtain 2-bromothiophene. This reaction requires attention to the choice of reaction temperature and solvent. Excessive temperature may cause the formation of polybrominated by-products; the polarity and solubility of the solvent also have a significant impact on the reaction process and product selectivity. Next, on the basis of 2-bromothiophene, the ethynyl group is introduced. It is often achieved by Sonogashira coupling reaction. This reaction requires a palladium catalyst, such as Pd (PPh), which works synergistically with ligands such as triphenylphosphine (PPh), and a base, such as potassium carbonate (K ² CO). 2-bromothiophene is mixed with ethynylation reagents, such as ethynyltrimethylsilane, in an organic solvent. During the reaction, the catalyst activity, the amount of ligand, the type and amount of base are all important factors affecting the reaction efficiency and product purity. After the reaction is completed, the target product 2-bromo-5-ethynylthiophene can be obtained by appropriate deprotection steps, such as using tetrabutylammonium fluoride (TBAF) to remove the silicon-based protective group.
Another synthesis method is to construct the ethynyl group first, and then introduce the bromine atom. This approach is also feasible, but the reaction conditions, reagent selection and side reaction control of each step need to be carefully considered and optimized to synthesize 2-bromo-5-ethynylthiophene efficiently and with high purity.

2-Bromo-5-ethynylthiophene is an important chemical in organic synthesis. During storage and transportation, there are many matters that need careful attention.
Bear the brunt, when storing, must choose a cool and dry place. This compound is prone to reaction in case of moisture. If moisture exists, it may cause decomposition and deterioration, which will damage its quality. If it is placed in a humid place, it is like a boat traveling in a sea of wind and rain, which is prone to disasters.
Second, the temperature must also be strictly controlled. High temperature can promote its decomposition or cause chemical reactions, so it should be kept in a low temperature environment, generally not exceeding 25 ° C. If the temperature is too high, it is like cooking oil in a hot fire, and its stability is difficult to maintain.
Furthermore, the choice of storage container is crucial. When using corrosion-resistant materials, such as glass or specific plastic containers, to prevent chemical reactions with the container. If the container material is not suitable, it will be like holding fire with wood, and accidents will occur.
As for transportation, shock resistance and anti-shock are the key. This compound may be more active in nature, causing bumps and vibrations or changes in its internal structure, which can cause danger. During transportation, when it is lightly loaded and unloaded, it should not be subject to strong impact, and fragile treasures should be protected.
And the transportation environment should also be the same as storage, to keep it in a cool and dry state. The escort should also be familiar with its characteristics and be able to handle it properly in case of emergencies, so that 2-bromo-5-ethynylthiophene can be safely stored and transported.

The price of 2-bromo-5-ethynylthiophene in the market is difficult to determine. The price of 2-bromo-5-ethynylthiophene often changes due to various reasons. The first to bear the brunt is the cost of production. The production of this compound may require special raw materials and exquisite processes. If the price of raw materials fluctuates, or the complexity of the process changes, the cost can fluctuate, which in turn affects its market price.
Furthermore, the state of supply and demand is also critical. If at some time, the industry's demand for 2-bromo-5-ethynylthiophene increases sharply, such as the sudden demand for large-scale use in the fields of pharmaceutical research and development, materials science, etc., and the supply is difficult to keep up, the price will rise. On the contrary, if the supply exceeds the demand, the price will drop automatically.
Again, the competitive situation of the market also affects the price. If all the manufacturers produce this product, the competition is fierce, and the price may be reduced in order to occupy the market. And if only a few companies have this capacity, the price may be able to maintain a high level.
And the difference in region also makes the price different. In different places, due to differences in transportation costs, tax policies, etc., the price is also different. In places with convenient transportation and tax incentives, the price may be lower than elsewhere. < Br >
Therefore, in order to determine the market price of 2-bromo-5-ethynylthiophene, it is necessary to observe the market dynamics in real time, consult suppliers, and compare quotations from different sources to obtain a more accurate number.