2-Bromo-3-hydroxymethyl-thiophene

2-Bromo-3-hydroxymethyl-thiophene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
First, it can be used as a pharmaceutical intermediate. In the process of creating new drugs, this compound is often a key starting material. The unique structure of the thiophene ring has good biological activity and chemical stability. Bromine atoms and hydroxymethyl groups can participate in a variety of chemical reactions. By ingeniously designing the reaction path, complex drug molecular structures can be constructed, which in turn helps to develop drugs for specific diseases.
Second, it is also useful in the field of materials science. It can be chemically modified to introduce it into polymer materials. With its special electronic structure and chemical properties, it can improve the electrical and optical properties of materials. For example, preparing materials with special photoelectric response, or improving the mechanical properties and stability of materials, for the manufacture of new electronic devices, optical sensors, etc.
Third, it is also an important cornerstone in the synthesis of fine chemicals. Fine chemicals with specific functions can be synthesized by reacting with other organic reagents, such as special fragrances, dyes, etc. Because of its strong structural modifiability, it can precisely design the synthesis route according to the required product properties, and prepare fine chemicals to meet different needs.
Overall, 2-bromo-3-hydroxymethyl-thiophene plays an indispensable role in many fields such as medicine, materials, and fine chemicals, promoting the development and progress of related industries.

For 2-Bromo-3-hydroxymethyl-thiophene, there are several ways to synthesize it. One method can be started with thiophene-containing compounds. First, bromide the specific position of the thiophene ring with an appropriate brominating agent, such as bromine or N-bromosuccinimide (NBS). In this process, it is necessary to pay attention to the control of the reaction conditions, such as temperature and solvent selection. If bromine is used as the brominating agent, the reaction in a non-polar solvent such as dichloromethane at a low temperature environment can selectively introduce bromine atoms into the 2-position of the thiophene ring to obtain 2-bromothiophene derivatives. Hydroxymethyl is introduced at
times. It is often reacted with 2-bromothiophene derivatives in the presence of formaldehyde or paraformaldehyde in the presence of basic catalysts such as sodium hydroxide or potassium carbonate. This reaction or through the nucleophilic substitution path, the hydroxymethyl group is successfully attached to the 3-position of the thiophene ring, and the final product is 2-Bromo-3-hydroxymethyl-thiophene.
Another method can start from the thiophene precursor with a specific substituent. First, the active group that may affect the reaction is protected by a protecting group, then brominated with a suitable brominating agent, then the protecting group is removed, and then the reaction of introducing hydroxymethyl group can also obtain the target product. This path requires careful selection of protecting groups and de-protecting conditions to avoid unnecessary effects on thiophene rings and other functional groups.
In addition, organometallic reagents can also assist in synthesis. For example, thiophene Grignard reagent or lithium reagent is reacted with bromine and hydroxymethyl reagents, and the unique reactivity of organometallic reagents is used to achieve the construction of the target molecule. However, this approach requires strict reaction conditions, and an anhydrous and oxygen-free environment is often indispensable, and the preparation of organic metal reagents also requires fine operation.

2-Bromo-3-hydroxymethyl-thiophene is also an organic compound. Its physical properties are well-researched.
Looking at its morphology, under room temperature and pressure, it is often in a liquid or solid state, but the definite state depends on the subtle intermolecular forces and structures. The atoms in the molecule are arranged in an orderly manner, and the bromine atoms, hydroxymethyl methyl groups and thiophene rings are related, resulting in its unique physical properties.
When it comes to melting points, due to the interaction of van der Waals forces and hydrogen bonds between molecules, it takes a specific energy to arrange molecules in an orderly manner, so the melting point is fixed. The electronegativity of bromine atoms is large, which makes the electron cloud shift and increases the intermolecular forces, and the melting point is relatively high.
The boiling point is also controlled by the intermolecular force. The strong intermolecular force requires more energy for gasification, and the boiling point is higher. In 2-bromo-3-hydroxymethyl-thiophene, hydroxymethyl can form hydrogen bonds, and the force of hydrogen bonds is stronger than that of ordinary van der Waals forces, so the boiling point is also affected by this and is in a certain range.
In terms of solubility, water is a polar solvent. This compound contains hydroxymethyl and has a certain polarity, so it has a certain solubility in water. However, the thiophene ring and the bromine atom have a certain non-polarity, which makes it difficult to fully dissolve in water, and in polar organic solvents such as ethanol and acetone, the solubility may be better, because of the similar miscibility.
Density is related to the mass and packing density of the molecule. The molecular weight of this compound is larger due to the presence of bromine atoms, and the packing density of the molecular structure also affects the density, so its density is different from that of common solvents and compounds, showing a specific value.
The color state of this compound is pure or colorless, but it may be yellowish due to impurities or light. Its smell, or due to the characteristics of the molecular structure, has a special smell, but the specific smell is difficult to describe in words, so it is necessary to experiment with smell perception.
In summary, the physical properties of 2-bromo-3-hydroxymethyl-thiophene are determined by its molecular structure, and all properties are interrelated, which is of great significance in chemical research and application.

2-Bromo-3-hydroxymethylthiophene is also an organic compound. The stability of its chemical properties is related to many reactions and applications, and is an important issue in chemical research.
In this compound, bromine atoms are active and can often initiate nucleophilic substitution reactions. Under suitable conditions, it can interact with many nucleophilic reagents, such as alcohols, amines, etc., and bromine atoms are easily replaced by nucleophilic groups. The hydroxymethyl part also has special activity due to the presence of hydroxyl groups. Hydroxy groups can participate in esterification reactions and react with acids to form esters; they can also be converted into aldehyde or carboxylic groups under oxidation conditions.
However, its stability is also affected by environmental factors. Under light or heating conditions, bromine atoms may detach, causing molecular structure changes. In alkaline environments, both hydroxyl and bromine atoms may participate in the reaction, causing structural changes in the compound. If there is water in the environment, water molecules or interact with the compound, affecting its stability.
In general, the chemical properties of 2-bromo-3-hydroxymethylthiophene are not absolutely stable, and can exhibit different activities and reactivity under different conditions. Chemists need to choose the reaction conditions reasonably according to their properties to achieve the target synthesis or application.

Nowadays, there is 2-bromo-3-hydroxymethyl-thiophene, which is difficult to determine in the market price range. Its price is determined by many factors, such as the wide and narrow source of materials, the difficulty of preparation, and the amount of market demand.
In the past, if the material source is abundant and the preparation is easier, the price may be slightly cheaper. If the preparation method is complicated, rare materials are required, or the environmental conditions are harsh, the price must be high. And if the market demand is strong, the supply is in short supply, and the price will also rise; if the demand is small, the supply exceeds the demand, and the price will naturally decline. < Br >
However, according to my investigation, the price of 2-bromo-3-hydroxymethyl-thiophene on the market may be between tens of yuan and hundreds of yuan per gram. This is only a rough figure and cannot be confirmed. For details, you need to consult the chemical material merchants or refer to the latest market conditions of the relevant trading platforms to obtain the actual price.