2-Benzoylthiophene

2-Benzoylthiophene is also an organic compound. It has a wide range of uses and has important applications in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. With its unique chemical structure, it can participate in the construction of molecular structures with specific pharmacological activities. For example, some drugs with antibacterial, anti-inflammatory or anti-tumor properties need to borrow 2-benzoylthiophene as the starting material in the synthesis path. After a series of chemical reactions, the required drug molecules are carefully constructed to contribute to human health.
Second, in the field of materials science, it also shows unique value. In the development of organic optoelectronic materials, 2-benzoylthiophene can be reasonably modified and assembled to become a key component in the construction of high-performance Light Emitting Diode (OLED), organic solar cells and other devices. Because it can regulate the electronic transport and optical properties of materials, the device has been significantly improved in terms of luminous efficiency and energy conversion efficiency, promoting the progress of materials science.
Third, in the field of fine chemicals, 2-benzoylthiophene can be used as a raw material for the synthesis of special fragrances, dyes and auxiliaries. With its chemical properties, through clever synthesis processes, fragrances with unique aromas or dyes with excellent dyeing properties can be created, adding color to the diversity of fine chemical products. In conclusion, although 2-benzoylthiophene is an organic compound, it plays an indispensable role in many fields such as medicine, materials, and fine chemicals, and plays an important role in promoting the development of various fields.

2-Benzoylthiophene is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
First, the appearance of 2-benzoylthiophene is often white to yellow crystalline powder at room temperature. This color state can be regarded as a preliminary identification feature in chemical experiments and industrial production. Its texture is delicate, and the feeling of touch is different from other substances. This is an intuitive physical property.
The melting point is about 58-62 ° C. The melting point is the critical temperature at which the substance changes from solid to liquid. For 2-benzoylthiophene, this melting point range is relatively fixed. Knowing the melting point is of great significance in the process of chemical separation and purification. If you need to obtain pure 2-benzoylthiophene from the mixture, you can control the temperature and operate near its melting point to achieve the purpose of separation.
Another boiling point is about 372.7 ° C. The boiling point is the temperature at which the liquid turns into a gas. A higher boiling point indicates that the intermolecular force of 2-benzoylthiophene is strong. In distillation and other operations, it can be distinguished from other substances with different boiling points according to its boiling point.
In terms of solubility, 2-benzoylthiophene is soluble in organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. This solubility property makes it possible to disperse the reactants uniformly with suitable organic solvents in organic synthesis reactions, promoting the smooth progress of the reaction. However, its solubility in water is not good, because the molecular structure of 2-benzoylthiophene is hydrophobic, and the force between water molecules is weak.
Density is also an important physical property. Although the specific value is not detailed, the size of the density affects its distribution in different media. In liquid-liquid separation or mixing systems, the density difference can be used as the basis for separation or judging the distribution of substances.
In addition, the odor of 2-benzoylthiophene also has characteristics, with a special organic odor. Although the description of odor is subjective, it can be used as a clue to preliminarily judge its existence in chemical operations. The physical properties of
2-benzoylthiophene, such as appearance, melting point, boiling point, solubility, density and odor, are all important properties. They are widely used in chemical research, industrial production and related fields, providing key basis for synthesis, separation, identification and other operations.

2-Benzoylthiophene is also an organic compound. The stability of its chemical properties is related to many ends.
In 2-benzoylthiophene, the thiophene ring is connected to the benzoyl group. The thiophene ring is aromatic, but it is weaker than that of benzene. Because the electronegativity of sulfur atoms in the ring is different from that of carbon atoms, and the electron cloud distribution is uneven. This structure makes it have unique reactivity.
In terms of stability, 2-benzoylthiophene is quite stable under generally mild conditions. Its intramolecular chemical bonds are tightly bound, and it can survive for a long time without deterioration under normal conditions. When encountering intense chemical reaction conditions, such as strong acids, strong bases or high temperatures, strong oxidants, etc., the stability is challenged.
In a strong acid environment, the thiophene ring may be protonated, causing electron cloud rearrangement, resulting in changes in its structure and properties. Strong bases interact with it, or cause reactions such as hydrolysis of benzoyl groups, breaking its original structure. At high temperatures, the thermal motion of molecules intensifies, the energy of chemical bonds increases, or reactions such as cracking and rearrangement occur. Strong oxidants can seize their electrons, oxidize thiophene rings or benzoyl groups, and damage their stability.
In summary, the chemical properties of 2-benzoylthiophene are still stable under conventional conditions, but in extreme chemical environments, the stability is difficult to survive and it is easy to undergo chemical changes.

2-Benzoylthiophene is also an organic compound. The methods for its preparation have also been various in the past.
First, thiophene and benzoyl chloride are used as starting materials and are prepared by Fu-gram acylation. Dissolve thiophene in an appropriate solvent, such as dichloromethane, and cool to a suitable temperature, usually at a low temperature, such as about 0 ° C. Slowly add a solution of benzoyl chloride containing anhydrous aluminum trichloride. This anhydrous aluminum trichloride is a catalyst, which can promote the reaction. Add it dropwise and gradually heat up to room temperature to make the reaction sufficient. In this reaction, the acyl group of benzoyl chloride is substituted at a specific position of thiophene to obtain 2-benzoylthiophene. However, this process needs to pay attention to the anhydrous environment, because water can deactivate the catalyst and affect the yield.
Second, it is obtained by the reaction of thiophene-2-boronic acid with benzoic acid derivatives. Thiophene-2-boronic acid and benzoic acid halide, such as benzoate bromine, react in an alkaline environment under the catalysis of palladium catalyst, such as tetrakis (triphenylphosphine) palladium (0). The commonly used base is potassium carbonate, etc., and the solvent can be a mixture of dioxane and water. This reaction is carried out under heated reflux conditions. After a complex catalytic cycle, the boron group of thiophene-2-boronic acid is coupled with the halogen atom of benzoic acid halide to obtain 2-benzoylthiophene. This method has good selectivity and high yield. However, palladium catalysts are expensive, and cost may be a consideration.
There are also thiophene and acetophenone as raw materials, which are prepared by specific oxidation rearrangement. Under the action of appropriate oxidants, such as m-chloroperoxybenzoic acid, the carbonyl ortho-position of acetophenone is connected to thiophene, and then converted into 2-benzoylthiophene through the rearrangement process. The reaction conditions of this route are relatively mild, but the precise control of the amount of oxidant and the reaction conditions depends on the purity and yield of the product.

The price of 2-benzoylthiophene in the market is difficult to determine quickly. The price often changes due to various factors, such as the abundance of production sources, the quality of quality products, and the urgency of demand.
Looking at the market conditions of the past, the price of this material fluctuates indefinitely. If the source is abundant, the supply is full, and the demand is not high, the price may tend to be flat, and the price per unit may be lower. However, if the origin changes, the output will drop sharply, and there are many demand, and the demand will exceed the supply, the price will rise and reach a higher position.
And the quality is also the main reason. Those with flawless refining and high purity will have a higher price than those with slightly more impurities and inferior purity. In addition, the route of trade, transportation fees, and tax regulations can also make the price different.
Due to the ever-changing market conditions, if you want to know the current price of 2-benzoylthiophene, it is better to consult the intercity merchants, chemical materials brokers, or carefully examine the price information platform of chemical raw materials, you can get a near-real price range, rather than being able to determine its exact number according to common words.