2-Aminothiophene-3-carboxylic acid t-butyl ester

2-% aminopyridine-3-carboxypyridine amide is a class of organic compounds with a specific structure. The physical properties of the two have their own unique characteristics.
2-aminopyridine, at room temperature, is mostly white to light yellow crystalline powder appearance. Its melting point is about 58-62 ° C, and its boiling point can reach 204-206 ° C. It can be soluble in common solvents such as water, ethanol, and ether. This is due to the interaction between the amino group and the pyridine ring in the molecule. It has a certain polarity and can interact with polar solvents to form hydrogen bonds. Because its structure contains basic amino groups, it can exhibit weak alkalinity in aqueous solutions and react with acids to form corresponding salts.
3-carboxylpyridyl amide, usually in solid form. Melting point is relatively high, or around 180-185 ° C. Because of its strong polarity in both carboxyl and amide groups, it has a certain solubility in water, and with the increase of temperature, the solubility may increase. The carboxyl group can ionize hydrogen ions, show acidity, and can neutralize with bases; the amide group makes it easy to form hydrogen bonds between molecules, which affects its physical properties such as melting point, boiling point and solubility. In addition, the compound can form complexes under specific conditions because it contains multiple polar functional groups or has certain coordination ability to certain metal ions. Overall, the physical properties of 2-aminopyridine and 3-carboxypyridine amides are determined by the functional groups within their molecular structures. These properties are of critical significance in many fields such as organic synthesis and medicinal chemistry, affecting their activity, solubility, and interaction with other substances in reactions.

To prepare 2-hydroxyvaleric acid and ethyl 3-chlorobutyrate, there are various methods.
Preparation of 2-hydroxyvaleric acid, one of which can be obtained by controlled reduction of glutaric anhydride. Glutaric anhydride encounters an appropriate amount of reducing agent, such as lithium aluminum hydride. After carefully adjusting the dosage and reaction conditions, the carboxyl group on one side is reduced to a hydroxyl group, and the carboxyl group on the other side is retained, so 2-hydroxyvaleric acid is obtained. When reacting, it is necessary to pay attention to the choice of reaction temperature and solvent. If the temperature is too high, it may cause excessive reduction; solvent discomfort will also affect the reaction process.
Second, it can be prepared by borohydration-oxidation reaction starting with valenic acid. In the reaction of pentanoic acid and borane, boron atoms are added to one end of the double bond to form an alkyl boron intermediate. After being oxidized by hydrogen peroxide and sodium hydroxide, the boron atoms are replaced by hydroxyl groups, and the anti-Markov rule is followed. Hydroxy groups are introduced at the end of the double bond containing more hydrogen to obtain 2-hydroxyvaleric acid. In this process, the amount of borane and the conditions of the oxidation step are very important.
As for the preparation of ethyl 3-chlorobutyrate, ethyl butyrate is often obtained by the reaction of butyric acid and ethanol catalyzed by concentrated sulfuric acid, and then chlorination. Butyric acid is mixed with ethanol, concentrated sulfuric acid is added as a catalyst, heated and refluxed, and an esterification reaction occurs to form ethyl butyrate However, the amount of sulfuric acid must be moderate, more will cause side reactions, and less will have poor catalytic effect. After that, ethyl butyrate reacts with chlorine under light or in the presence of an initiator, and chlorine atoms replace the α-hydrogen atoms adjacent to the carbonyl group in ethyl butyrate to obtain ethyl 3-chlorobutyrate. During the reaction, the light intensity and chlorine gas penetration rate are all related to the yield and purity of the product.
Or first esterified with 3-chlorobutyric acid and ethanol. 3-chlorobutyric acid and ethanol are esterified under the action of a catalyst to obtain 3-chlorobutyrate ethyl ester. The type of catalyst (such as p-toluenesulfonic acid, etc.), reaction time and temperature all have a significant impact on the reaction, and fine regulation is required to obtain satisfactory results.

2-%E6%B0%A8%E5%9F%BA%E5%99%BB%E5%90%A9 (2-aminopyridine) and 3-%E7%BE%A7%E9%85%B8%E5%8F%94%E4%B8%81%E9%85%AF (3-carboxypyridine) are used in many fields such as medicine, pesticides, and materials.
In the field of medicine, 2-aminopyridine can be used as a key intermediate to synthesize many bioactive compounds. For example, in the preparation of some antibacterial drugs, it can be cleverly combined with other molecules through specific chemical reactions to construct drug molecular structures with antibacterial effect. 3-Carboxypyridine also plays an important role in the field of drug development, such as some drugs used to treat cardiovascular diseases. After chemical modification, 3-carboxypyridine can become a key component of drug molecules, which has a significant impact on the activity and efficacy of drugs.
In the field of pesticides, 2-aminopyridine can participate in the synthesis of a variety of pesticides, such as some insecticides. With its special chemical structure, it can interfere with the nervous system or physiological metabolic process of pests, so as to achieve the purpose of insecticide. 3-carboxypyridine can also be used to synthesize pesticides with herbicidal or bactericidal properties, by affecting the balance of growth hormones in weeds or destroying the cell wall of pathogenic bacteria, etc., to exert its herbicidal and bactericidal effects.
In the field of materials, 2-aminopyridine can be used to prepare functional polymer materials. For example, in the synthesis of some conductive polymer materials, the amino group of 2-aminopyridine can be polymerized with other monomers, giving the material unique electrical properties. 3-carboxylpyridine can be used to prepare materials with special adsorption properties, and its carboxyl group can be complexed or chemically reacted with specific metal ions or organic molecules, thereby preparing adsorption materials with high selective adsorption capacity for specific substances, which are very useful in environmental monitoring and pollutant treatment.

In today's world, the business situation is complicated and the market is fickle. It is not easy to know the market price of 2-hydroxypyridine-3-carboxylate butyrolactone. This compound is useful in chemical, pharmaceutical and other fields, so its price is also affected by many factors.
The first to bear the brunt is the price of raw materials. The production of 2-hydroxypyridine-3-carboxylate butyrolactone requires all kinds of raw materials. If the production of raw materials encounters natural disasters, man-made disasters, or changes in government orders, its price will move, which will then affect the price of the finished product. If the raw material production area encounters droughts and floods, causing the production of raw materials to decrease, the price will rise, and the price of this compound will also rise.
The second is the process and production capacity. If the process is refined, the production capacity is greatly increased, and the market is full of goods, the price may decline; on the contrary, if the process is difficult, the production capacity is limited, and the supply is in short supply, the price will rise. New plants are put into operation, or old plants are expanded, reduced, or shut down, all of which have an impact on the quantity of goods in the market, thus affecting their prices.
Furthermore, the trend of demand. If the demand for it in industries such as pharmaceutical R & D and chemical production is strong, but the supply remains unchanged or the growth rate is not as good as the demand, the price should be high; if the demand is weak and the supply exceeds the demand, the price will If a new drug is developed, a large amount of this compound is required as raw material. For a while, there will be a shortage of demand and supply, and the price will soar.
In addition, market competition, policies and regulations, international situation, etc., are also the main factors affecting its price. The competition among peers is fierce, and there may be price reductions in order to compete for market share; policies and regulations set restrictions on environmental protection and production qualifications, etc., or cause costs to rise and prices to change; the international situation changes, trade friction and exchange rate fluctuations can disturb its market and prices.
In summary, the market price of 2-hydroxypyridine-3-carboxylate butyrolactone, such as changes in the situation, is influenced by multiple factors such as raw materials, processes, demand, competition, and policies. To know its exact price, it is necessary to observe changes in market conditions in real time and study the movements of various factors in order to obtain a more accurate number.

The storage conditions of 2-% hydroxypropyl-3-carboxybutylamide are quite exquisite. This substance should be placed in a cool, dry and well-ventilated place.
A cool place can protect it from high temperature baking. If the temperature is too high, the molecular movement will intensify, or its chemical structure will change, causing decomposition and deterioration, which will affect its quality and efficacy. Therefore, the storage temperature should be controlled between 15 ° C and 25 ° C. Such a mild temperature can ensure its stability.
A dry environment is also indispensable. If the air humidity is too high, moisture will easily adhere to it, which may cause it to absorb moisture and deliquescence. Once deliquescence, not only the physical form will change, but also chemical reactions may be induced, resulting in reduced purity and damaged activity. The relative humidity should be maintained at 40% to 60%, which can effectively avoid the worry of moisture.
Well ventilated can keep the surrounding air circulating and updated. If the air in the storage space is not circulated, it is difficult for water vapor and volatile substances in the local environment to spread, which can easily create an unfavorable microenvironment and have a negative impact on its preservation.
In addition, it needs to be stored away from fire and heat sources to prevent dangerous conditions due to accidental heating. It is also necessary to avoid coexisting in a room with strong oxidants, strong acids, strong alkalis and other chemicals. Due to their active chemical properties, contact with them may cause violent reactions, resulting in failure or even safety accidents. Attention should also be paid to shading and preservation. Strong light exposure may lead to luminescent chemical reactions and damage its structure and performance. Proper follow of these storage conditions can maintain a good state of 2% hydroxypropyl-3-carboxybutylamide for a long time.