2-aminothiophene-3-carboxylate

2-Aminothiophene-3-carboxylate is one of the organic compounds. Its physical properties are quite unique, and it is of great research value in the field of chemistry.
Looking at its appearance, under normal temperature and pressure, it is mostly in solid form. The color of this compound often varies according to its purity and crystalline state. Generally, it is either a white to light yellow powder or a crystal. The texture is fine, and its crystalline state can be seen under light.
When it comes to melting point, 2-aminothiophene-3-carboxylate has a specific melting point value. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This value is of great significance for the identification and purification of the compound. After many experiments, the melting point is within a certain temperature range. The exact value of this range varies slightly according to the specific substituents and preparation methods, but the approximate range can be used as a reference for research.
Solubility is also one of its important physical properties. 2-Aminothiophene-3-carboxylate shows different solubility properties in different solvents. In polar solvents, such as water and alcohols, its solubility is relatively good. Because the molecular structure of the compound contains polar amino groups and carboxyl groups, and the polar solvent molecules can form hydrogen bonds and other interactions, it is easier to dissolve. In non-polar solvents, such as alkanes, its solubility is poor, because of the weak force between molecules and non-polar solvents, it is difficult to miscible with each other.
Furthermore, the density of the compound is also a specific value. In terms of density, the mass per unit volume of a substance is also important for understanding its distribution in the solution system and the quantitative relationship when participating in chemical reactions. Although the exact value of its density needs to be determined by rigorous experiments, in general, it is roughly consistent with the density range of similar organic compounds.
In addition, the stability of 2-aminothiophene-3-carboxylate is also a physical property consideration. Under normal temperature and general environmental conditions, its chemical structure is relatively stable. However, under extreme conditions such as high temperature, strong acid, and strong base, its structure may change, triggering chemical reactions such as decomposition and hydrolysis. This is what must be paid attention to when storing and using the compound.

2-Aminothiophene-3-carboxylate is a genus of organic compounds. It has unique chemical properties and has important uses in many fields.
In terms of its chemical properties, it is weakly basic. Due to its amino group, it can react with acids to form corresponding salts. This reaction is also reversible. Under suitable conditions, the formed salt can be reconstituted into the original compound. And the carboxylate part can undergo hydrolysis reaction and dissociate in water to form corresponding carboxylic acids and bases.
Its reactivity is quite high. Amino groups can participate in various nucleophilic substitution reactions, such as reacting with halogenated hydrocarbons to form new carbon-nitrogen bonds, thereby introducing various functional groups, laying the foundation for the synthesis of complex organic molecules. The thiophene ring is also an active structure and can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Because the thiophene ring has aromatic properties, it can stabilize the reaction intermediates and make the reaction more likely to occur.
The stability of 2-aminothiophene-3-carboxylate is affected by environmental factors. Under high temperature, high humidity or strong acid and alkali conditions, its structure may change. However, under conventional storage conditions, the properties are still stable and can be stored for a long time.
Because of its unique chemical properties, 2-aminothiophene-3-carboxylate is very popular in the fields of medicinal chemistry, materials science and other fields. In medicine, it can be used as a potential pharmaceutical intermediate to synthesize compounds with specific biological activities through structural modification. In the field of materials, it can be used to prepare functional materials, such as conductive polymers, optical materials, etc., with its reactivity and structural characteristics, giving materials special properties.

2-Aminothiophene-3-carboxylate has a wide range of uses. In the field of medicine, it is often a key intermediate for the creation of new drugs. Taking the development of a new anti-cancer drug as an example, chemists used 2-aminothiophene-3-carboxylate as the starting material and successfully constructed a molecular structure with specific biological activities through multiple and delicate chemical reactions. The structure can precisely act on the specific target of cancer cells, block the growth and proliferation path of cancer cells, and bring new hope for solving cancer problems.
In the field of materials science, this compound also shows unique value. For example, in the preparation of organic optoelectronic materials, 2-aminothiophene-3-carboxylic acid esters can be ingeniously chemically modified and integrated into polymer systems. The resulting new organic materials have excellent photoelectric conversion properties and can be used to manufacture high-efficiency solar cells to convert solar energy into electricity more effectively, alleviating the current energy shortage dilemma.
Furthermore, in the field of pesticides, 2-aminothiophene-3-carboxylic acid esters can be derived from a series of compounds with high insecticidal and bactericidal properties. Such compounds have significant inhibitory and killing effects on a variety of crop pests and pathogens, and are less harmful to the environment than traditional pesticides, which is conducive to the sustainable development of agriculture. In conclusion, 2-aminothiophene-3-carboxylate plays an indispensable role in many fields such as medicine, materials, and pesticides, promoting technological innovation and progress in various fields.

The synthesis methods of 2-aminothiophene-3-carboxylic acid esters have existed in ancient times, and there are many kinds, each with its own advantages. The following briefly describes the common kinds.
First, thiophene is used as the starting material. First, thiophene is substituted at a specific position, and a suitable functional group is introduced. After multiple steps of reaction, such as halogenation, nitrification, reduction, etc. When halogenating, select a suitable halogenating reagent, and under appropriate reaction conditions, replace the halogen atom at a specific position of thiophene. This step requires attention to the control of the reaction conditions to avoid side reactions. Then nitrification, nitro is introduced. The regulation of reaction conditions in this step is crucial, which is related to the positioning and yield of nitro groups. After reduction, nitro is converted into amino groups to obtain key intermediates. After carboxylation reaction, carboxyl groups are introduced, and then esters are formed, and finally 2-aminothiophene-3-carboxylic acid esters are obtained.
Second, sulfur-containing heterocyclic compounds are used as the starting materials. Part of the sulfur-containing heterocyclic ring, whose structure is similar to that of thiophene, can also be the cornerstone of synthesis after appropriate modification and transformation. Thiophene ring is constructed by cyclization reaction, and amino and carboxyl-related functional groups are introduced at the same time. In this process, the choice of catalyst is particularly critical, which not only affects the reaction rate, but also affects the selectivity of the product. Then the functional groups are modified and transformed to complete the esterification reaction and achieve the synthesis of the target product.
Third, amino acids and sulfur-containing compounds are used as raw materials. The amino acid provides the amino group, and the sulfur-containing compound provides the skeleton part of the thiophene ring. The two undergo a condensation reaction to build the basic structure. Subsequent reactions such as cyclization, carboxylation and esterification are carried out. This path requires attention to the sequence of reactions in each step and the influence of reaction conditions on the chirality of amino acids to avoid changes in the optical activity of the product.
Although this synthesis method has different paths, it is necessary to carefully study the reaction conditions and weigh the advantages and disadvantages of each step in order to improve the yield and purity of the product and achieve the purpose of synthesis.

Today I have a question, what is the price range of 2-aminothiophene-3-carboxylate in the market. This is a fine chemical, and its price fluctuates, subject to multiple factors.
The first to bear the brunt is the purity of the product. If the purity is extremely high, almost perfect, and reaches the level of scientific research, it is suitable for high-end experiments and fine synthesis, and its price is high, or hundreds of yuan per gram.
Because its preparation requires exquisite craftsmanship and rigorous processes to remove impurities and ensure quality.
Furthermore, the production scale is also the key. During large-scale production, due to economies of scale, the unit cost can be reduced, and the price will also decrease. However, small-scale pilot run or customized products, due to low output, after cost sharing, the price per unit will be high.
The region where the supplier is located also has an impact. Located in a prosperous commercial port, the transportation is convenient, the logistics is smooth, the raw materials are easy to obtain, the cost may be reduced, and the price may be relatively close to the people; if it is located in a remote place, the transportation cost is high, and the price may rise.
In addition, the market supply and demand affect the price. Demand is strong, supply is tight, and prices will rise; if supply exceeds demand, manufacturers will compete for the market or reduce their prices.
In summary, the price of 2-aminothiophene-3-carboxylate can range from tens of yuan per gram to hundreds of yuan per gram, fluctuating widely due to the above factors.