2-aminothiophene-3-carbonitrile

2-Hydroxypropionaldehyde-3-acetaldehyde is widely used.
In the field of medicine, both are the raw materials for essential drugs. Such as many synthetic antibiotics and vitamins, 2-hydroxypropionaldehyde and 3-acetaldehyde are often the starting materials. By organic synthesis, molecules with specific pharmacological activities can be formed through several steps of reaction. Taking a certain type of drug for the treatment of cardiovascular diseases as an example, at the beginning of synthesis, 2-hydroxypropionaldehyde should be used as a base to introduce specific functional groups to gradually build the skeleton of drug molecules; 3-acetaldehyde is also a key intermediate in the vitamin synthesis path, helping to build a complex ring structure, which is related to the biological activity and efficacy of vitamins.
In the chemical industry, 2-hydroxypropionaldehyde can be used as an excellent solvent. Because of its certain polarity and solubility, it can dissolve many organic compounds. In the preparation of coatings and inks, the viscosity and drying rate of the system can be adjusted to make the coatings evenly coated, and the inks have bright colors and good adhesion. 3-acetaldehyde is an important monomer in synthetic resins and plastics. Such as polymerization reaction, can be prepared with specific properties of the polymer, widely used in the production of plastic products, such as common polyacetaldehyde plastic, with good mechanical properties and chemical stability, can be used to manufacture pipes, plates, etc.
In the fragrance industry, 3-acetaldehyde has a unique aroma, can be used as a fragrance component, to add a unique flavor to the flavor formula. Or fresh fruity, or light floral fragrance, depending on the proportion of its blending with other fragrances. 2-Hydroxypropionaldehyde Although the aroma is not as prominent as 3-acetaldehyde, it can be used as a reaction intermediate in the synthesis of some fragrances, chemically modified into compounds with special aroma, enriching the variety of fragrances.

There are various ways to synthesize 2-% hydroxyvalerynitrile-3-acetic acid, which are described in detail as follows:
First, the cyanoethanol method. Take an appropriate amount of cyanoethanol, place it in the reactor, add a suitable catalyst, often filled with basic substances, such as sodium hydroxide. Adjust the reaction temperature to a specific range, about 100-150 ° C, and stir. Under the action of basic catalysis, cyanoethanol undergoes hydrolysis, and the cyanyl group is converted to a carboxyl group, resulting in 2-hydroxyvalerynitrile-3-acetic acid. The reaction conditions of this route are relatively mild and the operation is relatively simple. However, the raw material cyanoethanol is toxic, and the production process needs to be strictly controlled to prevent leakage from endangering safety. < Br >
Second, diethyl malonate method. First, diethyl malonate and suitable halogenated alkanes are catalyzed by sodium alcohol to undergo nucleophilic substitution reaction to form a specific substituted diethyl malonate. It is then hydrolyzed and then decarboxylated to obtain the target product. Specifically, take diethyl malonate, dissolve it in anhydrous ethanol, add sodium alcohol, stir well, and add halogenated alkanes dropwise. After the reaction is completed, hydrolysis is added, and then decarboxylation is heated. This method is easy to obtain raw materials. Although the reaction steps are slightly complicated, the yield is quite high, and it has considerable application value in industrial production.
Third, aldol-ketone acetation. The condensation reaction takes place under the action of an alkaline catalyst. For example, a specific structure of aldehyde and ketone is selected, dissolved in an organic solvent, an alcohol solution of sodium hydroxide or potassium hydroxide is added, and the reaction is carried out at low temperature to form an intermediate containing hydroxyl and nitrile groups. After subsequent oxidation and other steps, it can be converted into 2-hydroxyvaleronitrile-3-acetic acid. This approach can flexibly adjust the structure of the product according to the different raw materials of aldehyde and ketone, but the reaction process requires fine control of the reaction conditions to ensure the smooth formation and conversion of intermediates.

2-Aminoglutaric acid, also known as glutamic acid, is a colorless to white crystalline or crystalline powder, odorless, with a special umami taste. Its melting point is about 225 ° C, the solubility in water is small, slightly soluble in ethanol, acetone, insoluble in ether, benzene and other organic solvents.
3-methanethiol is a colorless gas at room temperature, has the smell of rotten chives, melting point - 123 ° C, boiling point 6.9 ° C, density is higher than air, soluble in water, ethanol, ether, etc. Flammable, mixed with air can form explosive mixtures, in case of heat sources, open flames have the danger of combustion and explosion. It is often used as a reagent in organic synthesis, and produced as a by-product in some chemical production processes. Due to its unique odor, the addition of trace amounts of methyl mercaptan to gas can be used as a warning agent to detect gas leaks in a timely manner.

Both 2-aminopyridine and 3-methylpyridine are organic compounds, each with unique chemical properties, and are widely used in many fields.
2-aminopyridine, whose intramolecular amino group is connected to the pyridine ring, this structure gives it unique reactivity. In terms of acidity and alkalinity, amino groups have certain alkalinity and can react with acids to form salts. For example, when interacting with hydrochloric acid, corresponding ammonium salts are formed. Due to the electron-giving conjugation effect of amino groups, the electron cloud density of the pyridine ring increases, the electrophilic substitution activity increases, and the substituents mainly enter the 3rd or 5th position of the pyridine ring. For example, under suitable conditions, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can occur. At the same time, amino groups can participate in a variety of condensation reactions, such as reacting with alcaldes and ketones to form Schiff bases.
3-methylpyridine, because the methyl group is attached to the pyridine ring, the electron cloud density of the pyridine ring changes. The methyl group is the power supply group, which increases the electron cloud density of the pyridine ring, but compared with 2-aminopyridine, its reactivity is significantly different. In the electrophilic substitution reaction, the activity is slightly lower than that of 2-aminopyridine, and the substituent group mainly enters the 4th or 6th position of the pyridine ring. In addition, the methyl group can undergo some specific reactions, such as being oxidized to a carboxyl group under the action of an appropriate oxidant to form 3-pyridinecarboxylic Moreover, the methyl group of 3-methylpyridine can also participate in alkylation and other reactions.
The difference in chemical properties between the two is due to the different substituents. The amino group of 2-aminopyridine and the methyl group of 3-methylpyridine have different effects on the distribution and spatial structure of the electron cloud of the pyridine ring, resulting in different reactivity and reaction check points, and their applications in organic synthesis, pharmaceutical chemistry, materials science and other fields also have their own focuses.

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The first to bear the brunt is the difference in the place where it is produced. If the place where the medicine is produced is different, the soil and climate are different, and its quality and effect are different, the price will also change accordingly. For example, if the fertile ointment soil produced is produced, the essence of heaven and earth is obtained, and it is well-nourished, its quality is high and the price is high or high; if it is produced in a barren soil and evil state, it is difficult to grow and raise, and the quality is poor and the price is low or low.
Second, the supply and demand of the city are the main reasons. If the medical world is multi-used, there are many people who want it, and the production is limited, the price will rise; on the contrary, if there are few people who want it, and the supply exceeds the demand, the price will drop.
When the seasons change, the production and interest of the medicine are different, and the price is also different. For example, if it is easy to harvest and plant at a certain time, if the quantity is large, the price will be flat; if it is difficult to harvest and plant at a certain time, if the quantity is small, the price will rise.
There is also a business camp, and the costs of purchasing, storing, transporting, selling, etc. are all affected by the price. Purchasing costs are high, storage and transportation costs are high, and the cost of sales increases, and the price has to go up; if the way to obtain the camp saves costs, the price may stabilize or decrease.
Although it is difficult to determine the range of its price, it is normal to say that the price of this medicine in the market may be as low as a few dollars, or as high as a few silver coins, depending on the situation.