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2-Aminomethyl-5-bromothiophenem, what is the chemical structure of HBr?
The chemical structures related to 2-aminomethyl-5-bromothiophene and hydrobromic acid (HBr) are described below.
2-aminomethyl-5-bromothiophene, whose thiophene ring is a five-membered sulfur-containing heterocyclic structure, is connected to an aminomethyl (-CH ² NH ²) group at the second position of the thiophene ring. In this group, the carbon atom is connected to the thiophene ring, and the carbon atom is also connected to two hydrogen atoms and an amino group (-NH ²); at the fifth position of the thiophene ring, a bromine atom (Br) is connected.
When it exists in the system with hydrobromic acid (HBr), the amino group (-NH2O) can react with hydrobromic acid due to its certain alkalinity. The nitrogen atom in the amino group has a pair of lone pairs of electrons, which can accept the attack of hydrogen ions (H < unk >) in hydrobromic acid, and then form an ammonium salt structure, that is, the amino group is converted into -NH < unk >, and at the same time it is combined with bromine ions (Br). In the chemical structure after this reaction, the thiophene ring still maintains the basic structure of a five-membered sulfur-containing heterocycle, the amino methyl group at the second position becomes the -CH < unk > NH < unk > Brstructure, and the bromine atom at the fifth position is still attached to the thiophene ring. In this way, the chemical structure of 2-aminomethyl-5-bromothiophene after interaction with hydrobromic acid is formed.
2-Aminomethyl-5-bromothiophenem, what are the physical properties of HBr
The composition of 2-aminomethyl-5-bromothiophene and hydrobromic acid (HBr) has many physical properties. The appearance of this compound is often a specific state, or crystalline, with a white or slightly yellow color. It looks like a fine crystalline salt gathered in one place. Its texture is relatively stable under normal temperature and pressure, but it will also change under specific conditions.
When it comes to melting point, this substance has its inherent value. When the temperature gradually rises to a certain level, it will change from solid to liquid, just like ice and snow melting when warm. The number of boiling points is also its important property. Under a specific pressure, when heated to this temperature, it will turn into a gaseous state and disperse in space. < Br >
In terms of solubility, it varies in different solvents such as water, alcohols, and ethers. In water, or slightly soluble, only a little dissolves, and the water is slightly turbid; in some organic solvents, or can be better dissolved and fused, just like water and milk.
Density is also one of its characteristics. Compared with water, or heavier than water, put it into water, such as stone sinking to the bottom; or lighter than water, it floats on the surface of the water.
In addition, its smell may have a unique smell, or be pungent, or slightly peculiar, and the smell is discernible. And the sensitivity of the compound to external factors such as light and heat is also different. Excessive light or high temperature may cause chemical changes, such as color changes, component decomposition, etc., just like delicate flowers are not resistant to hot sun and high temperature.
2-Aminomethyl-5-bromothiophenem, what are the main uses of HBr?
2-Aminomethyl-5-bromothiophene and hydrobromic acid (HBr) have a variety of main uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to its unique chemical structure, it can participate in a series of chemical reactions to build complex drug molecular structures. By reacting with specific reagents, it can modify its structure and obtain compounds with specific biological activities, which is of great significance in the process of developing antibacterial, anti-tumor and other drugs.
In the field of materials science, it can be used as a starting material for the synthesis of functional materials. After chemical reactions, materials are endowed with special properties such as photoelectric properties and adsorption properties. For example, through specific polymerization reactions, or to prepare polymer materials with specific electrical or optical properties, it may have applications in electronic devices, optical sensors, etc.
In the field of organic synthetic chemistry, it is an important synthetic building block. With its activity of amino methyl and bromine atoms, it can connect different organic groups through nucleophilic substitution, coupling and other reactions, expand the structural diversity of organic molecules, provide the possibility for the synthesis of novel organic compounds, and contribute to the development and innovation of organic synthetic chemistry.
2-Aminomethyl-5-bromothiophenem, what are the synthesis methods of HBr
To prepare 2-aminomethyl-5-bromothiophene · HBr, there are many methods, which can be obtained from 5-bromothiophene-2-formaldehyde through multi-step reaction. First, 5-bromothiophene-2-formaldehyde reacts with sodium cyanide and ammonium chloride in an appropriate solvent to generate 5-bromothiophene-2-acetonitrile intermediates. In this step, attention should be paid to the mild reaction conditions to prevent side reactions from breeding. Then a suitable catalyst, such as Raney nickel, is used to catalyze the hydrogenation of 5-bromothiophene-2-acetonitrile in a hydrogen atmosphere to obtain 2-aminomethyl-5-bromothiophene, and finally react with hydrobromic acid to obtain the target product 2-aminomethyl-5-bromothiophene · HBr.
Or 5-bromo-2-chloromethylthiophene reacts with ammonia. 5-Bromo-2-chloromethylthiophene is reacted with excess liquid ammonia or ammonia gas at a certain temperature and pressure in a suitable reactor. Liquid ammonia is used as both a reactant and a solvent. After the reaction is completed, it is separated and purified, and then reacted with hydrobromic acid to obtain 2-aminomethyl-5-bromothiophene · HBr. However, this process should pay attention to the purity of 5-bromo-2-chloromethylthiophene, so as not to affect the yield and product purity.
Furthermore, 5-bromo-2-bromomethylthiophene is obtained by bromination with 5-bromothiophene as the starting material. In this step, the amount of brominating agent and reaction time are controlled to prevent excessive bromination. After that, 5-bromo-2-bromomethylthiophene reacts with ammonia, similar to the above method, to generate 2-aminomethyl-5-bromothiophene, and then reacts with hydrobromic acid to obtain the target product. There are many reaction steps in the whole process, and each step requires precise control of conditions to achieve high yield and purity.
2-Aminomethyl-5-bromothiophenem, what are the precautions in the use of HBr?
During the use of 2-aminomethyl-5-bromothiophene and hydrobromic acid (HBr), it is necessary to pay great attention to many key matters.
First, it is related to safety protection. Both of these are dangerous. Hydrobromic acid is a strong acid, which is highly corrosive and can easily cause serious burns to human skin, eyes, etc. When operating, be sure to wear complete protective equipment, such as acid and alkali resistant gloves, protective glasses, laboratory clothes, etc., to prevent accidental contact and injury. In case of unfortunate contact, rinse with plenty of water immediately and seek medical attention in time according to the injury.
Second, it is extremely important to control the reaction conditions. Temperature, reaction time and other factors have a great influence on the reaction process and product formation. If the temperature is too high, or the reaction is out of control, it will trigger side reactions and reduce the purity and yield of the target product; if the temperature is too low, the reaction rate will be delayed and take a long time. Therefore, it is necessary to precisely control the temperature according to the characteristics of the reaction. Generally, temperature control means such as water bath and oil bath can be used, and the reaction time is strictly controlled, and the reaction progress is regularly monitored.
Third, about the ratio of materials. The dosage ratio of 2-aminomethyl-5-bromothiophene to hydrobromic acid also has a significant impact on the reaction results. Improper ratio, or cause a reactant to remain, which not only wastes raw materials, but also brings difficulties to subsequent separation and purification. The dosage of the two should be accurately determined according to the stoichiometric relationship and experimental experience.
Fourth, the selection and construction of the reaction device should not be ignored. Appropriate reaction vessels and devices should be selected according to the reaction scale and reaction conditions to ensure good sealing of the device to prevent the volatilization of the reactants or the entry of external impurities and interfere with the reaction. At the same time, the device should be equipped with appropriate stirring, condensation and other equipment to promote the uniform progress of the reaction and heat exchange.
Fifth, the subsequent treatment process. After the reaction is completed, the separation and purification of the product is quite complicated. According to the nature difference between the product and the impurities, appropriate separation methods should be selected, such as extraction, distillation, recrystallization, etc., in order to obtain high-purity target products. And for the waste after the reaction, it is also necessary to follow environmental protection requirements, handle it properly, and do not discard it at will to avoid polluting the environment.
