2-Amino-5-phenylthiophene-3-carboxylic acid methyl ester

2-Amino-5-phenylthiophene-3-carboxylic acid methyl ester, this is an organic compound. Its chemical properties are unique, including amino, phenyl, thiophene ring and carboxylic acid methyl ester group functional groups.
Amino groups are basic and can react with acids to form corresponding salts. Under suitable conditions, amino groups can participate in nucleophilic substitution reactions and combine with electrophilic reagents such as halogenated hydrocarbons to form new nitrogen-containing derivatives.
Phenyl groups are aromatic and chemically stable, and can undergo electrophilic substitution reactions such as halogenation, nitration, sulfonation, etc. It can improve the hydrophobicity of compounds and affect the solubility and intermolecular forces of compounds. As a five-membered heterocyclic ring, the thiophene ring is also aromatic, and the electron cloud density distribution is different from that of the benzene ring, which makes its reactivity and selectivity unique. The hydrogen atom on the thiophene ring can participate in the electrophilic substitution reaction, and due to the presence of heteroatom sulfur, it can exhibit special electronic effects and three-dimensional effects.
Carboxylic acid methyl ester groups are ester functional groups, which are hydrolytic. Under acidic or basic conditions, hydrolysis will occur to generate corresponding carboxylic acids and methanol. Hydrolysis is more thorough under alkaline conditions, which is a common method for preparing carboxylic acids. At the same time, carboxylic acid methyl ester groups can participate in ester exchange reactions, and under the action of catalysts with other alcohols, different esters are formed.
This compound exhibits diverse chemical properties due to the synergistic effect of these functional groups, and has great potential for application in organic synthesis, medicinal chemistry, etc. It can be used as a key intermediate to construct more complex organic molecules.

There are various ways to synthesize methyl 2-amino-5-phenylthiophene-3-carboxylic acid. The common ones are that one can be started by a thiophene derivative containing the corresponding substituent.
First take a suitable thiophene substrate with a modifiable group on it. After halogenation, a halogen atom is introduced at a specific position in the thiophene ring. The halogen atom can be bromine or chlorine, etc., which is designed to create an opportunity for the subsequent introduction of phenyl groups. Subsequently, by a palladium-catalyzed coupling reaction, such as Suzuki coupling or Stille coupling, the halogenated thiophene is interacted with phenylboronic acid or other phenylation reagents to obtain a 5-phenylthiophene derivative.
Furthermore, a carboxyl group is introduced on the obtained 5-phenylthiophene derivative. It can be achieved by hydrolysis, oxidation and other steps. If the substrate contains hydrolyzable ester groups or cyano groups, etc., after hydrolysis, a carboxyl group can be obtained. Thereafter, methanol and the carboxyl-containing compound are catalyzed by suitable catalysts such as concentrated sulfuric acid or p-toluenesulfonic acid to perform an esterification reaction to obtain 2-amino-5-phenylthiophene-3-carboxylic acid methyl ester.
Another way is to construct a thiophene ring first. A compound containing precursors such as amino groups, phenyl groups and carboxyl groups is cyclized to form a thiophene ring. For example, a suitable sulfur-containing compound and an enone or an enamine with a suitable functional group are cyclized in the molecule under heating or in the presence of a catalyst to construct a thiophene ring structure, and then suitably modified to achieve the target product. In the process, each step of the reaction needs to pay attention to the precise control of the reaction conditions, such as temperature, reaction time, reactant ratio, etc., in order to obtain a higher yield and purity of 2-amino-5-phenylthiophene-3-carboxylic acid methyl ester.

Methyl 2-amino-5-phenylthiophene-3-carboxylate is a key compound in the field of organic synthesis. Its main uses are many, and in the field of medicinal chemistry, it is often an important intermediate for the creation of new drugs. The special structure of genthiophene and benzene ring endows the compound with unique physical and chemical properties, enabling it to interact with specific targets in organisms or have potential pharmacological activities, thereby assisting the research and development of new drugs.
In the field of materials science, it has also emerged. Due to its structural properties, it may be able to undergo specific chemical reactions to construct polymer materials with excellent performance. For example, copolymerization with other functional monomers is expected to prepare materials with special optical, electrical or mechanical properties, which may have broad application prospects in electronic devices, optical displays, etc.
In addition, in the field of organic synthetic chemistry, this compound is often used as a key building block to build more complex organic molecular structures. Chemists can derive many novel compounds by ingenious modification and reaction of their amino, ester and thiophene rings, which greatly enriches the variety of organic compounds and injects a steady stream of vitality into the development of organic synthetic chemistry.

2-Amino-5-phenylthiophene-3-carboxylic acid methyl ester, this is an organic compound. As for its market price, because most of the content recorded in Tiangong Kaiwu is traditional process technology, products, etc., there is no record of the price of such modern organic compounds, so it is difficult to answer accurately according to the ancient Chinese format.
However, in the modern market, the price of chemical products is influenced by many factors. First, the production scale and process have a significant impact. If the production technology is mature and large-scale, the cost may be reduced, and the price will also drop; conversely, if the production process is complex and the scale is small, the cost will be expensive. Second, the price of raw materials fluctuates greatly. The price of raw materials rises, and the price of products will also rise accordingly. Third, the market demand situation is crucial. If the demand is strong and the supply is limited, the price will rise; if the demand is low, the price may be suppressed.
Generally speaking, the price of fine chemicals varies greatly, from a few yuan per gram to several hundred yuan. If this compound is used in niche high-end pharmaceutical research and development fields, the price may reach more than 100 yuan per gram due to high purity requirements and small output; if it is used in more common chemical synthesis, and the production technology is mature and the output is large, the price may be several yuan to several tens of yuan per gram. However, the exact price needs to be consulted with chemical product suppliers or relevant market platforms.

2-Amino-5-phenylthiophene-3-carboxylic acid methyl ester, this substance is related to safety and toxicity, and it needs to be carefully investigated.
In the ancient theory of "Tiangong Kaiwu", although this substance is not directly described, the properties of many organic compounds are often judged by their structure and composition. 2-Amino-5-phenylthiophene-3-carboxylic acid methyl ester, containing amino group, phenyl group, thiophene ring and ester group. Amino groups have certain reactivity. Under specific conditions, they can participate in many chemical reactions, or form new substances. The properties of new substances are unknown, or there is a latent risk. Phenyl and thiophene rings are both aromatic structures. Some of these structures have a certain lipid solubility. If they enter the human body, they may easily penetrate the biofilm, thus interfering with physiological processes. Ester groups are relatively active, and hydrolysis reactions can occur when they encounter acid bases or specific enzymes. The properties of hydrolysis products also need to be considered.
When it comes to safety, how stable it is in the environment, whether it is easy to degrade, and whether the degradation products are harmful are all key. If it is not easy to degrade, or accumulate in the environment, it will endanger the ecology. For the human body, whether it will be absorbed through the skin, inhaled by the respiratory tract, or ingested by mistake is still inconclusive. Animal experiments may be required to observe its impact on the body, such as whether it irritates the skin and mucous membranes, and whether it is toxic, teratogenic, or carcinogenic < Br >
In terms of toxicity, from a structural point of view, although there are no typical highly toxic groups, it should not be ignored. Or active intermediates are produced due to the metabolic process, which react with biological macromolecules such as proteins and nucleic acids, destroying the normal function of cells. Or interfere with the human enzyme system and hinder the normal metabolism. Therefore, in order to determine its safety and toxicity, rigorous experiments and studies are needed to clarify its exact impact on life and the environment before it can be used rationally to avoid its harm and seek its benefits.