2-amino-4-chloro-5-formylthiophene-3-carbonitrile

2-Amino-4-chloro-5-formylthiophene-3-formonitrile is an organic compound with multiple unique chemical properties, which has attracted much attention in the field of organic synthesis.
It contains a nitrile group (-CN), which has high reactivity. The nitrile group can be hydrolyzed to form a carboxyl group (-COOH), which can be achieved through specific reaction steps under acidic or alkaline conditions. In alkaline hydrolysis, amide intermediates are formed first, followed by further hydrolysis to carboxylic acids. This process often requires heating to promote the reaction process.
Furthermore, formyl (-CHO) is also a key active site. Formalyl groups can participate in many classical organic reactions, such as condensation reactions with amine compounds to form Schiff bases. As an important intermediate in organic synthesis, Schiff bases are widely used in the fields of drug synthesis and materials science. In addition, formyl groups can also be converted into hydroxyl groups (-CH 2O OH) through reduction reactions, which can be achieved by common reducing agents such as sodium borohydride.
thiophene rings also play an important role in the structure of this compound. Thiophene rings are aromatic, which endows molecules with certain stability. At the same time, their electron cloud distribution characteristics make electrophilic substitution reactions at specific positions on thiophene rings prone to occur. Due to the localization effect of chlorine atoms and amino groups, electrophilic reagents are more inclined to attack specific positions of thiophene rings, which provides the possibility for the synthesis of derivatives with diverse structures.
Amino groups (-NH2O) also have significant reactivity. Amino groups are basic and can react with acids to form salts. And amino groups can participate in many nucleophilic reactions, such as reacting with halogenated hydrocarbons to form substituted amines. This reaction is crucial in the process of building carbon-nitrogen bonds and is widely used in the synthesis of drugs and natural products.
In summary, 2-amino-4-chloro-5-formylthiophene-3-formonitrile exhibits rich chemical reactivity due to the characteristics of various active groups and thiophene rings, providing many possibilities and research directions for organic synthetic chemistry.

2-Amino-4-chloro-5-formylthiophene-3-formonitrile is an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of medicine. Due to the precise construction of a specific molecular structure, the functional groups such as amino groups, chlorine atoms, formyl groups and nitrile groups contained in this compound can be connected with other molecular fragments through various chemical reactions, and then drug molecules with specific biological activities can be synthesized.
In the field of materials science, it also has important uses. Organic electronic materials are developing rapidly. Such compounds containing special functional groups may be chemically modified and processed to exhibit unique electrical and optical properties, providing a foundation for the research and development of organic Light Emitting Diodes, organic solar cells and other materials.
In addition, it is also used in the field of pesticide synthesis. Due to its specific chemical structure, or its inhibitory or killing effect on certain pests and pathogens, through rational design and synthesis, it may become an efficient and low-toxic pesticide active ingredient, which can help agricultural pest control and ensure crop yield and quality.
With its unique combination of functional groups, this compound plays an important role in many fields such as medicine, materials, pesticides, etc., providing a key material basis and research direction for the development of various fields.

To prepare 2-amino-4-chloro-5-formylthiophene-3-formonitrile, there are three methods.
First, it starts with sulfur-containing compounds and nitriles, and is obtained by condensation reaction in an appropriate solvent and under the action of a specific catalyst. This reaction requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it is easy to produce side reactions, resulting in a decrease in product purity and yield. For example, using a sulfur-containing reagent and a nitrile compound, in an organic solvent, catalyzed by a catalyst, the temperature is controlled in a certain range, and the reaction takes several times. After separation and purification, the product can be obtained.
Second, starting from thiophene derivatives, chlorine groups are first introduced, followed by formyl groups, and then amino groups and formonitrile groups are introduced. The order and conditions for introducing groups are the most important. For example, in a specific position of the thiophene ring, a chlorination reagent is used to introduce chlorine atoms in a specific reaction environment; later, a suitable formylation reagent is used to add formyl groups according to a specific reaction procedure; finally, the target product is obtained through specific amination and formonitrification steps. Each step requires precise control of reaction conditions, such as reagent dosage, temperature, pH, etc., to avoid side reactions, yield and purity.
Third, other heterocyclic compounds are used as raw materials and prepared through a series of reactions such as cyclization and substitution. This path requires a deep solution to the reactivity of the heterocyclic compound, and a reasonable reaction route is designed. For example, a heterocyclic compound forms a prototype thiophene ring through a cyclization reaction, and then several steps of substitution reaction are used to introduce chlorine, formyl group, amino group and formonitrile group in turn. The separation and purification operation after each step of the reaction is also critical, which is related to the final quality of the product.
Although there are many methods for preparing 2-amino-4-chloro-5-formylthiophene-3-formonitrile, it is necessary to carefully control the reaction conditions and make good use of the separation and purification art to obtain high-quality products.

2-Amino-4-chloro-5-formylthiophene-3-formonitrile has different solubility in different solvents. This compound contains amino groups, chlorine atoms, formyl groups and nitrile groups, and the chemical properties of these groups will affect its solubility.
In polar organic solvents, such as dimethyl sulfoxide (DMSO), because it forms hydrogen bonds or dipole-dipole interactions with the polar groups of the compound, it has good solubility. DMSO has strong polarity and can effectively disperse the compound and help it dissolve uniformly. Similarly, N, N-dimethylformamide (DMF) can also dissolve the compound well due to similar polar interactions.
However, in non-polar solvents, such as n-hexane, which only has weak van der Waals force and non-polar groups interact with compounds, 2-amino-4-chloro-5-formylthiophene-3-formonitrile has poor solubility and is almost insoluble.
In alcoholic solvents, although methanol and ethanol have polarity, hydroxyl groups can form hydrogen bonds with compounds, but due to the influence of carbon chains, the solubility may be inferior to DMSO and DMF. And with the growth of alcohol carbon chains, the polarity weakens and the solubility decreases.
Water, as a strong polar solvent, has poor solubility in water due to the existence of hydrophobic parts of compounds. However, if the compound forms an ionic state, such as aminoprotonation, its solubility in water may increase.
Overall, 2-amino-4-chloro-5-formylthiophene-3-formonitrile has better solubility in polar organic solvents, but it is difficult to dissolve in non-polar solvents. The solubility in water and some alcoholic solvents depends on specific conditions.

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