2-amino-4,5-dimethylthiophene-3-carboxamide

2-Amino-4,5-dimethylthiophene-3-formamide, this is an organic compound. To know its chemical structure, the naming convention can be deduced.
"Thiophene" is a sulfur-containing five-membered heterocyclic aromatic compound, and the atoms on the ring are numbered in sequence. " 2-Amino "indicates that the amino group ($- NH_ {2} $) is connected to the thiophene ring at position 2;" 4,5-dimethyl "indicates that there are two methyl groups ($- CH_ {3} $), one of which is at position 4 and the other is at position 5;" 3-formamide ", the epitroformamide group ($- CONH_ {2} $) is connected to the thiophene ring at position 3.
In summary, the chemical structure of 2-amino-4,5-dimethylthiophene-3-formamide is: on the thiophene ring, the amino group at position 2, the formamide group at position 3, and the methyl group at position 4 and position 5 are each connected. Its structure can be expressed as $C_ {7} H_ {10} N_ {2} OS $, and the atoms are connected by covalent bonds to form a specific spatial structure. Due to the type, number and connection order of atoms, it has unique chemical properties and reactivity.

2-Amino-4,5-dimethylthiophene-3-carboxamide, Chinese name 2-amino-4,5-dimethylthiophene-3-formamide, this substance has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of many drugs. The structure of Gainthiophene is of great significance in pharmaceutical chemistry and has unique biological activities and pharmacological properties. Taking the development of anti-cancer drugs as an example, compounds containing this structure may interact with specific targets of cancer cells or block the proliferation signaling pathway of cancer cells, thus exerting anti-cancer effects. In terms of antimicrobial drugs, studies have also shown that such compounds have inhibitory effects on the growth of some bacteria, or can become the basis for new antimicrobial drugs.
In the field of materials science, 2-amino-4,5-dimethylthiophene-3-formamide can be used to prepare functional materials. Because it contains specific functional groups, it can participate in polymerization reactions, and then synthesize polymer materials with special electrical and optical properties. For example, synthesize conductive polymers, which have potential applications in organic electronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells. In OLEDs, conductive polymers can be used as charge transport layers to improve the luminous efficiency and stability of devices; in organic solar cells, it may improve the photoelectric conversion efficiency.
In the field of agricultural chemistry, it may be used to create new pesticides. In view of its structural characteristics or unique mechanism of action against certain pests and pathogens, high-efficiency, low-toxicity and environmentally friendly pesticides have been developed, which can not only effectively control crop diseases and pests, ensure crop yield and quality, but also reduce the negative impact on the environment. In short, 2-amino-4,5-dimethylthiophene-3-formamide has important application potential in many fields such as medicine, materials, and agriculture, providing new opportunities and directions for the development of various fields.

2-Amino-4,5-dimethylthiophene-3-carboxamide is an organic compound whose physical properties are particularly important for its performance in various chemical processes and practical applications.
The appearance of this compound is often solid or crystalline. Its melting point is a key physical parameter. By accurately measuring the melting point, its purity and identification of the compound can be determined. Due to the different purity of the compound, the melting point may vary.
Solubility is also an important physical property. In organic solvents, such as common ethanol, acetone, etc., or exhibit some solubility. This property allows the compound to act as a reactant or intermediate in specific organic synthesis reactions, and the reaction rate and process can be regulated by the selection of suitable solvents. In water, its solubility or poor, due to the limited hydrophilicity of the groups contained in the molecular structure.
The density of this compound is also a consideration. Although the exact value may need to be accurately determined experimentally, the density data is of great significance in chemical production, separation and purification processes. The density will affect the distribution of compounds in different media and the phase separation process.
Furthermore, its boiling point cannot be ignored. The level of boiling point reflects the strength of the intermolecular force of the compound. A higher boiling point implies a stronger intermolecular force, which is crucial for controlling the reaction conditions during heating, distillation, etc., to ensure that the compound remains stable within a specific temperature range and does not evaporate or decompose prematurely.
The various physical properties of 2-amino-4,5-dimethylthiophene-3-carboxamide, such as appearance, melting point, solubility, density, and boiling point, are related to each other and affect each other, all-round determine its application direction and practical efficacy in the field of chemistry.

To prepare 2-amino-4,5-dimethylthiophene-3-carboxamide, the method of organic synthesis is often followed. There may be many ways, one of which is described here.
First, a suitable starting material, such as a thiophene derivative with the corresponding substituent group, can be introduced into the thiophene ring with a methyl substituent, or a specific halogenated thiophene and a methylating agent can be introduced into the thiophene ring. According to the principle of nucleophilic substitution, under suitable reaction conditions, such as selecting an appropriate base and solvent, temperature control and control, the methyl group is successfully connected to the 4th and 5th positions of the thiophene ring.
Then, a carboxyl group is introduced into the thiophene derivative containing dimethyl. By reacting with carbon dioxide or other carboxylation reagents, such as metal-catalyzed carboxylation reactions, select metal catalysts such as palladium and nickel, and cooperate with suitable ligands, in a suitable reaction system, the introduction of carboxyl groups at the 3 position of the thiophene ring can be achieved.
After obtaining a product containing carboxyl groups, it can be converted into carboxyamides. The carboxyl group can be first converted into an acid chloride, and reacted with reagents such as thionyl chloride, the resulting acid chloride has a very high activity. Then it reacts with ammonia or amine reagents, and through nucleophilic substitution, the acid chloride is converted into a carboxyamide group.
As for the introduction of amino groups, different strategies can be followed. Or in the previous steps, the raw material with amino latent functional groups is selected and converted into amino groups through a series of reactions; or after the carboxylamide is formed, the amino group is introduced at the 2 position of the thiophene ring by a specific reaction, such as nitro reduction. During this process, careful control of conditions such as temperature, pH, and ratio of reactants is required in each step to promote the smooth reaction to obtain high-purity 2-amino-4,5-dimethylthiophene-3-carboxamide.

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