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What is the main use of 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile
2-Amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile is an important compound in the field of organic synthesis. It is widely used in the field of medicinal chemistry and is often used as a key intermediate to construct drug molecules with specific biological activities. Many studies have shown that compounds containing such structures have potential effects on a variety of disease targets. For example, in the process of anti-tumor drug development, new drugs that can precisely act on tumor cells can be designed and synthesized by modifying and modifying their structures.
In the field of materials science, 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile is also used. Due to its unique molecular structure, the material is endowed with specific electrical and optical properties. For example, in the preparation of organic optoelectronic materials, its introduction into the material system can improve the charge transport performance of the material, thereby improving the efficiency and stability of organic optoelectronic devices.
In addition, in the field of organic synthetic chemistry, it acts as a reaction substrate and participates in many chemical reactions, providing the possibility for the construction of more complex organic molecular structures. Through ingenious design of reaction pathways and the use of its active groups, the formation and transformation of various chemical bonds can be realized, providing new strategies and methods for the development of organic synthetic chemistry.
In summary, 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile plays an important role in many fields such as drug development, materials science and organic synthesis due to its unique structure and properties, and has an important value in promoting technological progress and innovation in related fields.
What are the synthesis methods of 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile
To prepare 2 - amino - 4, 5, 6, 7 - tetrahydrobenzo [b] thiophene - 3 - carbonitrile, there are various methods. One common way is to react with compounds containing sulfur and nitrogen as the basis through several steps.
First take suitable thiols and unsaturated nitriles, and react with nucleophilic addition under appropriate catalysts and reaction conditions. Among them, the choice of catalyst is quite important, and it depends on the properties of the reactants and the temperature and pressure of the reaction. Common catalysts, such as some transition metal salts or organic bases, can promote the reaction, so that the sulfur atom of thiol nucleophilic attack the unsaturated bond of unsaturated nitrile, resulting in a key intermediate.
Then, the intermediate is subjected to a cyclization step. By heating or adding specific cyclization reagents, the functional groups in the molecule interact to form a ring system of benzothiophene. This step requires controlling the temperature and time of the reaction to prevent side reactions from occurring. If the temperature is too high or the time is too long, or the ring is rearranged or overreacted, etc., and the yield of the target product is reduced. < Br >
There are also other methods, such as halogenated aromatics and polyfunctional reagents containing sulfur and nitrogen, which are initiated by a metal-catalyzed coupling reaction, and then followed by ring-closing and modification. Metal-catalyzed coupling reactions often use metals such as palladium and nickel as catalysts to efficiently construct carbon-carbon and carbon-heteroatomic bonds. The whole process of
preparation requires detailed regulation of the reaction conditions of each step, such as reaction temperature, solvent selection, and the proportion of reactants, all of which are related to the purity and yield of the product. And after each step of the reaction, when the appropriate separation and purification means, such as column chromatography, recrystallization, etc., to remove impurities, in order to obtain a pure product, the final obtained 2 - amino - 4, 5, 6, 7 - tetrahydrobenzo [b] thiophene - 3 - carbonitrile.
What are the physical and chemical properties of 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile
2-Amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile, this is an organic compound. Its physical and chemical properties are crucial for its application in various fields.
First talk about the appearance and properties. Under normal temperature and pressure, it is often solid, mostly white to light yellow crystalline powder. This color and shape are easy to observe and operate in many experiments and production scenarios.
In terms of melting point, it has been accurately determined to be about 160-165 ° C. As a key physical property, the melting point is of great significance for its identification and purity judgment. If the melting point of the sample matches the standard value, and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting range is wide or the melting point deviates from the standard, or contains impurities.
Solubility is also an important property. This compound is slightly soluble in water, but can be better dissolved in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF). In organic synthesis reactions, the choice of solvent is closely related to the solubility of the compound. Only the right solvent can ensure the smooth progress of the reaction.
Let's talk about chemical properties. In the 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile molecule, the amino group, cyano group and benzothiophene ring all have specific reactivity. Amino groups can participate in nucleophilic substitution reactions, react with acyl halides, acid anhydrides, etc., to form corresponding amide derivatives, which are often used in drug synthesis to construct key structural units. Cyanyl groups can be converted into carboxyl groups through hydrolysis reactions or amino groups through reduction reactions, expanding their application paths in organic synthesis. Benzothiophene rings are rich in electrons and prone to electrophilic substitution reactions. Various functional groups are introduced into aromatic rings, providing the possibility for the synthesis of derivatives with diverse structures.
In addition, because the compound contains multiple activity checking points, under appropriate conditions, it can participate in cyclization reactions to construct more complex polycyclic systems, which has great application potential in the field of organic synthetic chemistry and lays the foundation for the creation of novel organic molecules.
2-Amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile in which areas
2-Amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile (2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile) has applications in many fields.
In the field of pharmaceutical research and development, it may be a key raw material for the creation of new drugs. Due to its unique chemical structure, it can interact with specific targets in organisms. For example, some inhibitors targeting specific disease-related proteins are being developed as starting materials, and through a series of chemical modifications and reactions, compounds with precise pharmacological activities are constructed for the treatment of diseases such as cancer and inflammation. < Br >
In the field of materials science, it can be used as a key component in the synthesis of special functional materials. With its structural properties, it may endow materials with unique optical and electrical properties. For example, in the synthesis of organic optoelectronic materials, the introduction of this structural unit is expected to improve the charge transfer efficiency and luminescence properties of materials, and is applied to organic Light Emitting Diodes (OLEDs), solar cells and other devices.
In the field of pesticide chemistry, it also has potential value. After rational molecular design and modification, compounds with high insecticidal, bactericidal or herbicidal activities can be derived. Because of its mechanism of action on specific biological targets, it may lay the foundation for the development environment-friendly and highly selective pesticides, and help the sustainable development of agriculture.
With its special structure, this compound has shown important application prospects in many fields such as medicine, materials, and pesticides, providing new opportunities and directions for technological innovation and development in various fields.
What is the market outlook for 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile
2-Amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile, Chinese name 2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3-formonitrile, this compound has emerged in the field of medical chemistry, with broad prospects and real potential.
The current market of Guanfu, although its scale is not extremely prosperous, is growing vigorously. The reason is that it plays a key role in drug development. Many researchers are looking for innovative drugs with high efficiency and low toxicity, and their attention is focused on this. Taking the research and development of anti-tumor drugs as an example, many experiments have shown that compounds containing this structure exhibit inhibitory activity on specific tumor cells, which is expected to open up a new path for the creation of anti-cancer drugs, attracting many pharmaceutical companies and scientific research institutions to participate in it, increase R & D investment, and then drive up market demand.
Furthermore, in the field of drug development for the treatment of neurological diseases, there are also studies suggesting that the compound may modulate neurotransmitters and have potential value in the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. This prospect has attracted great attention from the academic and industrial circles, and has promoted its market prospects. Although there is no large-scale industrialization yet, the research heat is on the rise, and technological breakthroughs can be expected. With time, when its synthesis process is optimized and costs are reduced, it will surely shine in the market and become a bright pearl in the field of medicine and chemical industry.