2-Amino-3-Thiophenecarboxamide

The chemical structure of 2-amino-3-thiophenoformamide is an important content in the field of organic chemistry. This compound is composed of a thiophene ring as the base, with a two-position hydrazine group and a three-position hydrazine group on the ring.
The thiophene ring is a five-membered heterocycle with aromatic properties, co-constructed by four carbon atoms and one sulfur atom. Its unique electron cloud distribution makes the thiophene ring electron-rich and has unique activity in many chemical reactions.
The two-position hydrazine group (-NH -2) is nucleophilic. Nitrogen atoms have lone pairs of electrons, which can participate in nucleophilic substitution, addition and other reactions. The amino group can be protonated, and it is easy to obtain protons to form ammonium ions (-NH 🥰 🥰) in an acidic environment. This property affects the acidity, alkalinity and solubility of the compound.
Tri-linked formamide group (-CONH 🥰), the amide group has a resonant structure, and the electron delocalization between the nitrogen atom of the carbonyl group (C = O) and the amino group stabilizes the structure. The carbonyl group in the formamide group is electrophilic and can react with nucleophiles; the amino group can also participate in the formation of hydrogen bonds, which has a great influence on the physical and chemical properties of the compound.
In summary, the chemical structure of 2-amino-3-thiophene formamide, due to the synergy of thiophene ring, amino group and formamide group, endows the compound with various chemical activities and characteristics, and has potential application value in organic synthesis, medicinal chemistry and other fields.

2-Amino-3-thiophenoformamide is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the creation of new drugs in the field of medicinal chemistry. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help synthesize compounds with specific pharmacological activities, such as the development of antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials science, it also has important applications. Or it can be used to prepare functional polymer materials. By virtue of its polymerization reaction with other monomers, the material is endowed with unique electrical, optical or mechanical properties, such as improving the conductivity of the material and improving the fluorescence properties of the material.
Furthermore, in agricultural chemistry, it may be used as a raw material for the synthesis of new pesticides. By modifying and modifying its structure, pesticides with high insecticidal, bactericidal or herbicidal properties can be created, contributing to the pest control and weed control of agricultural production.
Because of its chemical activity, it is often used as a cornerstone for the construction of more complex organic molecules in the field of organic synthetic chemistry. Through various organic reactions, the structural diversity of organic compounds can be expanded to meet the needs of different fields for special organic compounds.

The synthesis methods of 2-amino-3-thiophene formamide have been used in ancient times, and the methods are different. Here is a detailed description for you.
First, thiophene is used as the starting material. First, thiophene is substituted under specific conditions to introduce carboxyl functional groups. This step requires careful control of the reaction conditions, such as temperature, pressure and the ratio of the reactants, all of which are related to the success or failure of the reaction. The reagents used should be pure and suitable, so that the reaction can be carried out efficiently to obtain thiophene-3-carboxylic acid. Then, the carboxylic acid is reacted with an ammonia source. The choice of ammonia source is very critical, and the commonly used ones are ammonia gas, ammonia water or specific ammonium salts. This reaction process also needs to be precisely regulated. After the amidation reaction, the final product is 2-amino-3-thiophenoformamide.
Second, start from the sulfur-containing compound. Find a sulfur-containing precursor with a suitable structure. After multiple steps, the thiophene ring is gradually constructed, and the amino group and formamide group are introduced at a suitable stage. This path requires precise planning of the reaction steps. The intermediates of each step of the reaction must be properly processed and purified to ensure the purity and yield of the final product. For example, the thiophene ring is first constructed by cyclization reaction, and then the desired functional group is connected in turn through selective substitution reactions.
Third, the reaction is catalyzed by transition metals. Transition metal catalysts can play a unique role in this synthesis, which can promote the formation and transformation of specific chemical bonds. A transition metal salt is used as a catalyst, with suitable ligands, in a suitable reaction system, the reactants are coupled and added, and the synthesis of 2-amino-3-thiophenylformamide is skillfully realized. Although this method has high technical requirements, it can provide a more novel and efficient synthesis strategy.
The above synthesis methods have their own advantages and disadvantages. It is necessary to carefully choose according to actual needs, considering factors such as the availability of raw materials, the difficulty of reaction, the purity and yield of the product, etc., in order to achieve the ideal synthesis effect.

2-Amino-3-thiophenylformamide, this is an organic compound. Its physical and chemical properties are unique, let me tell you in detail.
Looking at its physical properties, under room temperature and pressure, it is mostly in the state of white to off-white crystalline powder. This state makes it clean in appearance, uniform in texture, and easy to handle and use in many experimental and industrial processes. Its melting point is in a specific range, about 180-184 ° C. The stability of the melting point provides an important basis for identification and purity determination. When heated to this temperature range, the compound gradually melts from solid to liquid, and this phase transition process has a great impact on its processing and application.
When it comes to solubility, 2-amino-3-thiophenylformamide exhibits different affinities in organic solvents. Its solubility in dimethyl sulfoxide (DMSO) is quite good, and it can be dissolved at a higher concentration to form a homogeneous solution. This characteristic makes DMSO often an excellent solvent for the reaction or analysis of this compound. In common alcoholic solvents such as methanol and ethanol, it also has some solubility, but its solubility is slightly lower than that of DMSO. In water, its solubility is very small, which is due to the action of hydrophobic groups in its molecular structure.
Its chemical properties are active, rich in active functional groups such as amino groups and formamido groups. Amino groups are basic and can neutralize with acids to form corresponding salts. This reaction is often used in organic synthesis to prepare specific derivatives or to adjust the pH of compounds. Formamido groups are also reactive and can participate in a variety of condensation reactions, such as condensation with algens or ketones, forming new carbon-nitrogen bonds, expanding molecular structures, and laying the foundation for the synthesis of complex organic compounds. The thiophene ring, as the core structure of the compound, endows it with aromaticity and certain chemical stability. However, the electron cloud on the thiophene ring is unevenly distributed, and electrophilic substitution reactions, such as halogenation and nitrification, can occur at specific locations, thereby introducing different functional groups, enriching the variety of compounds, and expanding its applications in medicine, materials and other fields.

There are 2-amino-3-thiophenoformamide in the market today, what is its price? This is a fine chemical product with a wide range of uses, often involved in the fields of medicine, pesticides, and materials. The range of its price is difficult to hide, due to multiple factors.
First, purity is the key. If the purity is high, almost flawless, reaching the scientific research level, suitable for high-end experiments and precise synthesis, its price must be high, or more than 100 yuan per gram, or even higher, to meet the strict requirements of scientific research.
Second, the market supply and demand are also heavy. If there are many people who want it, the supply will exceed the demand, and the price will rise; on the contrary, if there is an excess supply and there is little demand, the price may drop.
Third, the difficulty of preparation has a deep impact. If the preparation requires complex processes, rare raw materials, and harsh conditions, the cost will increase greatly, and the price will also be high.
Fourth, brands and merchants are also variables. Well-known brands have good reputation and stable quality, and their prices may be higher than others.
Roughly speaking, ordinary industrial grade products cost hundreds of yuan per kilogram; if they are high-purity fine products, they cost tens of yuan to more than 100 yuan per gram. However, these are all approximations, and the actual price should be subject to the current market and specific merchant quotations. For the exact price, you can consult chemical product suppliers and trading platforms in detail to get an accurate number.