2 Amino 3 Thiophenecarbonitrile
quinoline thiophene imidazole thiazole

2-Amino-3-thiophenecarbonitrile

Taiy Chemical

    Specifications

    HS Code

    961009

    Chemical Formula C5H4N2S
    Molar Mass 124.16 g/mol
    Appearance Solid (usually white or off - white)
    Physical State At Room Temp Solid
    Melting Point 163 - 167 °C
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
    Odor Odorless or very faint odor
    Stability Stable under normal conditions, but sensitive to strong acids and bases

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    General Information
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    Frequently Asked Questions

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    What is the chemistry of 2-Amino-3-thiophenecarbonitrile?
    2-Amino-3-thiophenoformonitrile is one of the organic compounds. Looking at its structure, the thiophene ring has aromatic properties, which endows this compound with certain stability. The presence of amino groups and nitrile groups gives it unique chemical properties.
    Amino (-NH ²) is basic and can react with acids to form salts. In this compound, amino groups can participate in many nucleophilic reactions, including its nitrogen atom with solitary pair electrons, which can attack electrophilic reagents. For example, under appropriate conditions, nucleophilic substitution reactions can occur with halogenated hydrocarbons, and the nitrogen atom of the amino group replaces the halogen atom to form a new carbon-nitrogen bond, thereby deriving compounds with more complex structures. < Br >
    The nitrile group (-CN) is also active in nature and can undergo hydrolysis reaction. Under acidic or basic conditions, it can be gradually converted to carboxyl (-COOH) or amide (-CONH ³). Under reduction conditions, the nitrile group can be reduced to an amine group, providing a way for the preparation of compounds containing multiple amino groups. The
    thiophene ring, as the core structure of this compound, affects the distribution of its electron cloud, and the reactivity of the amino group and nitrile group connected to it is regulated by it. For example, the change of electron cloud density on the thiophene ring affects the nucleophilicity of the amino group and the electrophilicity of the nitrile group, which in turn affects the reaction tendency of the compound as a whole. In addition, 2-amino-3-thiophenylformonitrile is often used as a key intermediate in the field of organic synthesis due to its unique structure and chemical properties. It is used to prepare many organic compounds such as drugs, pesticides and functional materials, and plays an important role in the field of modern chemical synthesis.
    What are the common synthetic methods of 2-Amino-3-thiophenecarbonitrile?
    2-Amino-3-thiophenoformonitrile is also an important intermediate in organic synthesis. There are many common synthesis methods, and each has its own ingenuity. Let me come one by one.
    One is the method of using thiophene as the starting material. First, thiophene is subjected to a specific reaction, and a suitable substituent is introduced to make it change at a specific position in the thiophene ring. For example, with bromine and other reagents, under appropriate conditions, thiophene is brominated to obtain bromothiophene. This bromide can be used with reagents containing amino groups and cyano groups in suitable catalysts and reaction environments to perform nucleophilic substitution reactions. The amino group is provided by an amine reagent, and the reaction temperature, time and proportion of the reactants are carefully adjusted to replace the bromine atom with the amino group. Then, the cyanogen-containing reagent is also nucleophilic substitution to introduce the cyanyl group into the corresponding position of the thiophene ring, so as to obtain 2-amino-3-thiophenoformonitrile.
    The second is to use the thiophene derivative as the starting material. For example, a specific thiophene derivative already has some of the required functional groups. After ingeniously designing the reaction route, the original functional groups are modified or transformed first. Or through oxidation, reduction and other reactions, the activity and properties of its functional groups are changed, and then the structure of the target product is gradually constructed through condensation, cyclization and other steps. Through the rational selection of reaction reagents and conditions, the reaction can proceed smoothly in the direction of generating 2-amino-3-thiophenoformonitrile.
    The third is the synthesis path catalyzed by transition metals. Transition metal catalysts often have unique effects in organic synthesis. Complexes of metals such as palladium and copper are used as catalysts to couple the substrate containing thiophene structure with reagents containing amino groups and cyanos. This method requires precise control of the catalyst dosage, ligand type and reaction atmosphere. In the presence of suitable solvents and bases, the substrate and reagents are selectively coupled under the action of catalysts, and 2-amino-3-thiophenoformonitrile is efficiently generated. This pathway often has the advantages of mild reaction conditions and good selectivity, providing an effective way for the synthesis of this compound.
    All these synthesis methods are the wisdom crystallization in the field of organic synthetic chemistry, providing rich strategies and means for obtaining 2-amino-3-thiophenoformonitrile.
    2-Amino-3-thiophenecarbonitrile in what areas?
    2-Amino-3-thiophenecarbonitrile is useful in many fields. In the field of pharmaceutical creation, this compound can be a key raw material for the synthesis of new drugs. Due to its special chemical structure or unique biological activity, it can act on specific biological targets and show excellent efficacy in the treatment of diseases, such as anti-cancer and antibacterial.
    In the field of materials science, 2-amino-3-thiophenecarbonitrile also has its own unique features. It can participate in the preparation of functional materials, such as optoelectronic materials. Due to its thiophene-containing structure, or endowing the material with special electrical and optical properties, it is expected to be used in the manufacture of organic Light Emitting Diodes, solar cells and other devices to improve their performance and efficiency.
    Furthermore, in the field of organic synthetic chemistry, 2-amino-3-thiophenoformonitrile is often used as an important synthetic building block. Chemists can modify and derive it through various chemical reactions to construct more complex and diverse organic molecular structures, contributing to the development of organic synthetic chemistry.
    In agricultural chemistry, new pesticides may be developed based on 2-amino-3-thiophenoformonitrile. Its special chemical properties may inhibit or kill some pests and pathogens, and it is more environmentally friendly than traditional pesticides, which contributes to the sustainable development of agriculture.
    In short, 2-amino-3-thiophenoformonitrile has important application potential in many fields such as medicine, materials, organic synthesis, and agricultural chemistry, providing new opportunities and possibilities for progress in various fields.
    What is the market outlook for 2-Amino-3-thiophenecarbonitrile?
    2-Amino-3-thiophenoformonitrile, the market prospect of this product in today's world, is really worth exploring.
    In the chemical industry, due to its unique chemical structure, it is often used as a key intermediate in many organic synthesis reactions. As far as pharmaceutical chemistry is concerned, it plays an important role in the research and development path of many new drugs. Today's pharmaceutical industry is eager for innovative drugs. 2-Amino-3-thiophenoformonitrile has attracted the attention of many pharmaceutical companies and scientific research institutions due to its ability to participate in the construction of a variety of active molecular structures.
    In the field of materials science, with the rapid development of high-tech materials, this compound has also emerged. In the preparation process of some functional materials, it can be used as a unique structural unit to give materials such as special optical and electrical properties.
    From the perspective of market supply and demand, with the expansion of downstream industries, such as pharmaceuticals, materials and other industries, the demand for 2-amino-3-thiophenoformonitrile is on the rise. However, the complexity of its production process and cost control are also important factors affecting market supply. Although some companies have mastered relevant production technologies, they still need to overcome many technical problems in order to stabilize supply on a large scale.
    Furthermore, the global market competition situation is also a key consideration. International chemical giants and emerging chemical companies are paying attention to this field and want to get a share of the 2-amino-3-thiophenylformonitrile market. Therefore, although the future market prospect is broad, the competition will also become fierce. Enterprises need to make efforts in technological innovation, cost control, product quality improvement and other aspects to stay ahead of the market wave.
    What are the physical properties of 2-Amino-3-thiophenecarbonitrile?
    2-Amino-3-thiophenylformonitrile, this physical property belongs to the category of organic chemistry. It is a solid, and it may appear white to light yellow powder. The melting point is in a specific range, which is a key parameter for identifying its purity and characteristics.
    When it comes to solubility, it can show certain solubility in common organic solvents, such as dichloromethane, N, N-dimethylformamide. However, the solubility in water is poor. Due to the limited hydrophilic groups in the molecular structure, hydrophobic thiophene rings account for a large proportion.
    Its chemical stability is quite important. It can exist stably under normal temperature and pressure and dry environment. In case of strong acid, strong base, or extreme conditions such as high temperature and high humidity, the molecular structure may change, triggering a chemical reaction. Gain amino and nitrile groups are both reactive and easily interact with acid-base reagents.
    In terms of spectral characteristics, infrared spectroscopy can reveal characteristic absorption peaks. Nitrile groups also have their own unique absorption peaks at amino groups or at specific stretching vibration peaks, which is a powerful means to identify molecular structures. Nuclear magnetic resonance spectroscopy can provide information on the chemical environment of hydrogen and carbon atoms in molecules, helping researchers to clarify the details of molecular structures.
    In the field of organic synthesis, 2-amino-3-thiophenylcarboxonitrile contains active groups, which are often used as key intermediates. By reacting with other organic reagents, complex organic molecules can be constructed, with potential applications in medicinal chemistry, materials science, and other fields.