2-AMINO-3-CYANO-4-CHLORO-THIOPHENE-5-CARBOXALDEHYDE

2-Amino-3-cyano-4-chloro-thiophene-5-formaldehyde, this substance has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to synthesize drug molecules with specific biological activities. Due to the structure of thiophene and the characteristics of its connected functional groups, it can participate in a variety of chemical reactions. After ingenious design and transformation, it can prepare drugs with therapeutic effects on specific diseases.
In the field of materials science, it also shows unique value. With its structural characteristics, it can be used as a basic unit for the construction of new organic materials. After chemical modification and polymerization, it is expected to prepare materials with special photoelectric properties, such as organic Light Emitting Diode (OLED), solar cells and other devices, to help improve the performance and efficiency of such devices.
In the field of organic synthesis, it is an important synthetic building block that can react with many reagents to build more complex organic compounds. By reacting with different nucleophiles and electrophilic reagents, the molecular structure can be precisely regulated, and a series of compounds with important research significance and application value in organic synthetic chemistry can be synthesized. Its application prospects in many scientific research and industrial fields have attracted the attention and research of many scientific researchers and related industries.

To prepare 2-amino-3-cyano-4-chloro-thiophene-5-formaldehyde, the method of organic synthesis is often followed. There are many methods, each with its advantages and disadvantages, and varies according to the availability of raw materials, the difficulty of reaction conditions, and the high and low yields.
First, it can be started from a suitable thiophene derivative. If there is a thiophene with a suitable substituent, it can be introduced into the 4-position by a halogenation reaction with a chlorine atom. The halogenation method is often carried out with chlorine gas, chlorination reagents such as N-chlorosuccinimide, etc., under suitable solvents and reaction conditions. Then, after cyanization, a cyano group is introduced at the 3-position. In cyanidation, sodium cyanide, potassium cyanide and other cyanides are often reagents, and specific catalysts and reaction environments are also required. Then, after amination, an amino group is introduced at the 2-position. This step requires ammonia sources such as ammonia gas and amine compounds, and is accompanied by suitable catalysts and temperature and pressure conditions. Finally, by oxidation or other suitable reactions, an aldehyde group is formed at the 5-position. There are many oxidizing agents available, such as mild manganese dioxide.
Second, or a multi-step reaction can be followed to construct a thiophene ring. First, a compound containing sulfur, nitrogen and suitable substituents is cyclized to form a thiophene ring. In this process, the reaction conditions and raw materials are cleverly designed to introduce the required amino, cyano and chlorine atoms at suitable positions. Then, after subsequent modification, the target aldehyde group is obtained.
Synthesis requires fine control of the reaction conditions, such as temperature, pH, reaction time, etc. And after each step of the reaction, separation and purification are often required to remove impurities and obtain a pure product, so that the synthesis is smooth and the expected yield and purity are achieved.

2-Amino-3-cyano-4-chloro-thiophene-5-formaldehyde, this is an organic compound. Looking at its structure, it has amino group, cyano group, chlorine atom and aldehyde group, and this group has its unique physical properties.
When it comes to properties, under normal temperature and pressure, most of them are in a solid state, due to the existence of various forces between molecules, such as hydrogen bonds, Van der Waals forces, etc., which promote the tight arrangement of molecules. However, its exact state may also be affected by impurities and preparation conditions.
In terms of melting point, due to the strong intermolecular forces with polar groups, the melting point is relatively high. The interaction between polar groups requires more energy to overcome before the substance can change from solid to liquid.
In terms of solubility, the compound may have a certain solubility in polar organic solvents. Amino, cyano and aldehyde groups are all polar groups. According to the principle of similar miscibility, they are easily soluble in polar solvents such as methanol, ethanol, dimethyl sulfoxide, etc. In non-polar solvents, due to the weak interaction between molecules and solvents, the solubility is low.
In terms of stability, amino groups can participate in acid-base reactions, and in the case of strong acids or bases, the structure may change. Cyanide groups are relatively stable, but under specific conditions, such as high temperatures, strong acids and bases, or catalysts, reactions such as hydrolysis can occur. Although the chlorine atom is relatively stable, it may be replaced in the nucleophilic substitution reaction. The aldehyde group has high reactivity and is easily oxidized to a carboxyl group or has an addition reaction with nucleophilic reagents.
The physical properties of this compound are crucial for its application in organic synthesis, medicinal chemistry and other fields. During synthesis, the appropriate solvent should be selected according to its solubility; considering the stability, the appropriate reaction conditions should be selected to ensure the smooth progress of the reaction.

2-Amino-3-cyano-4-chloro-thiophene-5-formaldehyde, an organic compound containing a variety of functional groups. It has a variety of chemical properties due to its unique structure.
Let's start with the amino group (-NH2O), which is a basic functional group. In acidic media, the nitrogen atom of the amino group can bind protons with lone pairs of electrons, resulting in the basic nature of the compound, which can react with acids to form corresponding salts. For example, when reacted with hydrochloric acid, hydrochloric salts can be formed.
Cyano (-CN) is also a key functional group. Cyanos are active and can participate in many reactions. The hydrolysis reaction is one of them. Under acidic or alkaline conditions, the cyanyl group can be gradually hydrolyzed to a carboxylic group (-COOH). If hydrolyzed under alkaline conditions, the amide (-CONH ²) is formed, and if hydrolyzed further, it becomes a carboxylate. After acidification, carboxylic acids can be obtained.
Furthermore, the chlorine atom (-Cl) acts as a halogen atom, giving the compound some properties of halogenated hydrocarbons. In the nucleophilic substitution reaction, the chlorine atom can be replaced by a variety of nucleophiles. For example, in the reaction with sodium alcohol, the chlorine atom can be replaced by an alkoxy group (-OR) to form ether compounds.
The chemical properties of aldehyde groups (-CH The aldehyde group is highly reductive and can be oxidized to a carboxyl group by weak oxidants such as Torun reagent (silver ammonia solution), and the silver mirror phenomenon will appear during the reaction; it can also be oxidized by Feilin reagent to form a brick-red cuprous oxide precipitate. At the same time, the aldehyde group can condensate with compounds containing active hydrogen, such as alcohols, to generate hemiacetals or acetals. The
thiophene ring, as the core structural part of this compound, is aromatic and can participate in typical reactions of aromatic compounds, such as electrophilic substitution reactions. Due to the characteristics of the electron cloud density distribution on the ring, the substitution reaction mostly occurs at a specific location.
The above functional groups do not exist in isolation, but interact with each other, which makes the chemical properties of 2-amino-3-cyano-4-chloro-thiophene-5-formaldehyde more complex and diverse, and shows broad application potential in the field of organic synthesis.

2-Amino-3-cyano-4-chloro-thiophene-5-formaldehyde in the market, what is the price? This is a special organic compound in fine chemicals, used in the field of medicine and pesticide synthesis.
In the past, the price often varies depending on quality, source and purchase quantity. If it is an ordinary commercial grade, the purity is about 95%, and the batch purchase is 100 grams, and the price per gram may be between tens and hundreds of yuan. If you want high-purity products, the purity is more than 98%, and the amount is small, such as less than ten grams, the price per gram may rise to hundreds of yuan.
However, the market of chemical industry is turbulent. Raw material market, process innovation, and supply and demand trends can all cause their prices to fluctuate. For example, if the price of raw material chlorine sources rises sharply, or the cost of this material increases, the price also rises. Or if a new synthesis method comes out, the production efficiency increases and the cost decreases, the price may drop.
And the price varies in different areas of the market. Prosperous commercial ports, convenient logistics, fierce competition, prices may stabilize; remote places, inconvenient transportation, scarce supply, prices may be slightly higher. In order to know the real-time price, you need to consult chemical raw material suppliers and trading platforms, and compare the quotations of each company in detail to get a near-real price.