2-AMINO-3-CYANO-4-CHLORO-5-FORMYLTHIOPHENE

2-Amino-3-cyano-4-chloro-5-formylthiophene, an organic compound with unique chemical properties.
From the structural point of view, the thiophene ring is its core structure, and the amino group, cyano group, chlorine atom and formyl group are all connected to it. The presence of amino groups imparts a certain alkalinity to this compound, because the nitrogen atom in the amino group contains lone pairs of electrons and can accept protons. Cyanyl groups have high chemical activity, and their triple bonds can undergo addition reactions, such as interacting with nucleophiles, and then derive various nitrogen-containing derivatives, which are often used as key intermediates in organic synthesis. The electronegativity of the
chlorine atom is relatively large, which can change the distribution of molecular electron clouds and affect the reactivity. In the nucleophilic substitution reaction, it can be replaced by other nucleophilic groups, which is an important way to construct new chemical bonds. As an active functional group, the
formyl group can participate in many reactions. If it can undergo acetalylation with alcohols, it can be used in organic synthesis to protect aldehyde groups; it can also participate in oxidation reactions to generate corresponding carboxylic acids; or it can undergo condensation reactions with ammonia and its derivatives to generate nitrogen-containing heterocyclic compounds.
Furthermore, this compound has certain stability due to the existence of a conjugate system, and the conjugate effect can delocalize electrons and reduce molecular energy. At the same time, the conjugate structure also affects its spectral properties, which can be used for qualitative and quantitative analysis in the ultraviolet-visible spectrum or at specific absorption peaks.
In short, the interaction of various functional groups of 2-amino-3-cyano-4-chloro-5-formylthiophene endows it with various chemical reactivity, and may have wide application prospects in organic synthesis, medicinal chemistry and other fields.

2-Amino-3-cyano-4-chloro-5-formylthiophene is an important compound in organic synthesis. The common synthesis methods are described in detail as follows:
The starting material is often selected as a suitable thiophene derivative. One method starts with chlorine-containing thiophene and adds a cyanyl group through cyanylation reaction. When cyanylation is carried out, cyanide reagents such as potassium cyanide or sodium cyanide are mostly used under appropriate solvent and catalytic conditions. Catalyzed substances, or salts of transition metals, such as copper salts, can help the cyanyl group to connect smoothly to the thiophene ring.
After obtaining the cyanothiophene, the amination reaction is continued. In this step, ammonia sources, such as liquid ammonia or organic amines, are often used to replace the corresponding groups on the thiophene ring in a specific reaction environment. The reaction environment is very important, and the temperature, pressure and reaction time are all related to the effect of amination.
As for the introduction of formyl groups, formylation is often used. Vilsmeier-Haack reagents such as DMF (N, N-dimethylformamide) and phosphorus oxychloride can be selected. This reagent interacts with thiophene derivatives reacted in the first two steps to introduce formyl groups efficiently. In the formylation reaction, factors such as the proportion of reagents, reaction temperature and time have a great influence on the yield and purity of the product.
There is also a synthetic path, first introducing formyl group, followed by cyanylation and aminylation, and the target product can also be obtained. However, the reaction conditions need to be carefully adjusted in each step to make the reaction proceed in the expected direction to obtain a high-purity 2-amino-3-cyano-4-chloro-5-formylthiophene. The whole process of
synthesis requires careful separation and purification of the reaction products at each step. Column chromatography, recrystallization, etc. are commonly used to remove impurities and obtain pure products to ensure that they can be used for subsequent scientific research or industrial production.

2-Amino-3-cyano-4-chloro-5-formylthiophene, an organic compound, has a wide range of uses in the field of organic synthesis. Looking at its structure, the amino group, cyano group, chlorine atom and formyl group each have their own unique chemical activities. These activity checking points make the compound able to participate in a variety of chemical reactions, and play a key role in the construction of complex organic molecular structures.
In the field of pharmaceutical chemistry, or it can be used as a starting material, through various reactions, carefully crafted to synthesize compounds with specific biological activities. Due to its unique structure, it can be precisely combined with specific targets in organisms, demonstrating biological activities such as antibacterial, antiviral, and anti-tumor, opening up possible paths for the development of new drugs.
In the field of materials science, the compound may impart novel optoelectronic properties to the material after being modified by specific reactions. For example, if a cleverly designed and synthesized conjugated polymer is introduced into this structural unit, the electron cloud distribution of the material can be adjusted, and its luminescence and conductivity properties can be optimized, which may have potential application value in the manufacturing of optoelectronic devices such as organic Light Emitting Diode (OLED) and organic solar cells. In organic synthetic chemistry, as a key intermediate, it can participate in many classic organic reactions such as nucleophilic substitution, electrophilic substitution, and cyclization by virtue of the activities of amino, cyano, chlorine atoms, and formyl groups. It helps to synthesize complex and diverse organic molecules, contributes to the development of organic synthetic chemistry, and promotes progress in the total synthesis of complex natural products.

2-Amino-3-cyano-4-chloro-5-formylthiophene is a very important organic compound. When storing, many key things need to be paid attention to.
The first to bear the brunt, temperature control is the key. This compound is quite sensitive to temperature and should be stored in a cool place to avoid decomposition or deterioration due to high temperature. High temperature may cause its structure to change, impairing its chemical properties and purity. Generally speaking, the storage temperature should be maintained at 2-8 ° C, which can effectively slow down its chemical reaction rate and maintain its stability.
Second, the effect of humidity should not be underestimated. This compound should be kept away from humid environments due to moisture or neutralization, hydrolysis or other side reactions. The storage place must be dry, and a desiccant can be placed next to the storage container to absorb excess water vapor and keep it dry.
Furthermore, light will also have an effect on it. 2-Amino-3-cyano-4-chloro-5-formylthiophene may be sensitive to light, and strong light exposure or photochemical reaction may cause it to change its chemical structure. Therefore, it should be stored in a light-shielded container or stored in a dark place to avoid light damage.
In addition, the choice of storage container is also quite important. It is advisable to use a corrosion-resistant and well-sealed container to prevent reaction with the material of the container and ensure that it does not leak. Glass or plastic containers, if applicable, should ensure that the material does not interact with the compound.
During handling and storage, care should be taken to prevent damage to the container due to vibration and collision, causing compound leakage. At the same time, relevant safety procedures should be strictly followed and personal protection should be taken, because some of these compounds may be toxic or irritating. In this way, the purpose of properly storing 2-amino-3-cyano-4-chloro-5-formylthiophene can be obtained to ensure its quality and stability.

There is a question today, what is the market price of 2-amino-3-cyano-4-chloro-5-formylthiophene. This is a key material in the field of fine chemicals, and its price often varies due to many factors.
Looking at the past chemical material market, the supply of raw materials has a deep impact on its price. If the raw materials on which thiophene depends are abundant and stable, its price may stabilize or even decline due to competition; on the contrary, if the raw materials are scarce, the price will rise. This is one.
Furthermore, the production process is also an important factor. If a new and efficient method comes out, the production cost will be reduced and the production capacity will increase, the market supply will increase, and the price will decrease accordingly. On the contrary, if the process is complicated and the cost is high, the price will also be difficult to lower.
The state of market demand also affects its price. If the downstream industry has strong demand for 2-amino-3-cyano-4-chloro-5-formylthiophene, but the supply is limited, the price will rise; if the demand is low and the supply is excessive, the price will fall.
If you want to know the specific market price, you must check the current chemical trading platform, manufacturer quotation, or consult the industry experts. Because the price is not static and often changes with the market, it is difficult to give a definite number. Only by tracking market dynamics in real time and carefully reviewing supply and demand, craftsmanship, etc., can a more accurate price be obtained.