2-Acetylbenzothiophene

2-Acetylbenzothiophene is an important member of organic compounds. It has a wide range of uses and is involved in various fields.
The first is the field of medicinal chemistry. Because of its specific chemical structure and activity, it can be the cornerstone of drug development. By modifying and modifying its structure, researchers hope to create new compounds with unique pharmacological activities to treat various diseases. For example, in the development of anti-cancer drugs, 2-acetylbenzothiophene may be chemically modified to target specific targets of cancer cells, inhibit the proliferation of cancer cells, induce their apoptosis, and open up a new path for the development of anti-cancer drugs.
Furthermore, the field of materials science is also indispensable. This compound can be used as a key raw material for the construction of functional materials. Due to its chemical stability and optical properties, it can be used to prepare organic optoelectronic materials. If applied to organic Light Emitting Diode (OLED), it can optimize its luminescence performance, improve device efficiency and stability, and contribute to the advancement of display technology. In the preparation of solar cell materials, it can improve the light absorption and charge transfer efficiency of batteries, and promote the development of renewable energy technology.
In organic synthesis chemistry, 2-acetylbenzothiophene is often used as a key intermediate. Chemists can use a variety of chemical reactions as a starting material to build more complex organic molecules. By reacting with different reagents, carbon-carbon bonds and carbon-heteroatom bonds are formed, enriching the structural diversity of organic compounds and providing possibilities for the synthesis of various natural products and fine chemicals.
In summary, 2-acetylbenzothiophene plays a pivotal role in many fields such as medicine, materials and organic synthesis, and promotes the continuous development of related science and technology.

2-Acetylbenzothiophene is also an organic compound. Its physical properties are quite important and are related to many practical applications.
Looking at its properties, it is mostly crystalline under normal circumstances, and the color is either white or nearly white. The shape is like a fine powder. The appearance is uniform and the appearance is quite textured.
When it comes to the melting point, it is about 58 to 60 degrees Celsius. This melting point characteristic is a key indicator in the purification, identification and heating change of substances. When heated to this temperature, the substance gradually melts from the solid state to the liquid state. The temperature accuracy of this process depends on the relevant process operations.
The boiling point is also one of its important physical properties. At about 296 to 298 degrees Celsius, the substance changes from liquid to gaseous. The boiling point reflects the strength of the intermolecular forces, which is of great significance for its separation, distillation and other operations.
In terms of solubility, 2-acetylbenzothiophene is soluble in common organic solvents, such as ethanol, ether, chloroform, etc. In ethanol, it can be uniformly dispersed to form a clear solution. Due to the existence of suitable interactions between molecules and ethanol molecules, such as van der Waals force, hydrogen bond, etc., the two are soluble. However, in water, its solubility is very small, and its molecular structure has strong hydrophobicity. The force between water molecules and solute molecules is difficult to overcome the force between solute molecules, so it is difficult to dissolve. < Br >
Density is also a property that cannot be ignored. Its density is about 1.26g/cm ³, which indicates the mass per unit volume. When it comes to material mixing, separation and product design, the density data can provide a basis for material accounting, equipment selection, etc. The physical properties of
2-acetylbenzothiophene, such as properties, melting point, boiling point, solubility, density, etc., are of key value in the research and production of chemical industry, materials, medicine and other fields, and are the basis and guidance for related work.

2-Acetylbenzothiophene is one of the organic compounds. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
This compound contains a benzothiophene parent nucleus with an acetyl group attached at the second position. The benzothiophene parent nucleus endows it with certain aromaticity and stability, while the introduction of acetyl groups significantly changes its electron cloud distribution and greatly affects its chemical activity.
From the perspective of physical properties, 2-acetylbenzothiophene is often in a solid state, and its melting and boiling point is affected by intermolecular forces. There is a van der Waals force and possible weak interaction between its molecules, and the melting boiling point reaches a certain value. The specific melting boiling point value varies depending on the purity and measurement conditions.
When it comes to chemical activity, the acetyl group is a strong electron-absorbing group, and the electron cloud density on the benzothiophene ring is reduced by induction and conjugation effects. In this way, the electrophilic substitution reactivity on the ring changes, and electrophilic substitution is more or less likely to occur at specific positions. For example, when interacting with halogenating reagents, the reaction check point and rate will be different from benzothiophene itself due to the influence of acetyl groups.
In 2-acetylbenzothiophene, the carbonyl group (contained in the acetyl group) is active. It can react with nucleophiles, such as with alcohols catalyzed by acids or bases, to form acetals or semi-acetals. It can also participate in reduction reactions. Carbonyl groups can be reduced to alcohol hydroxyl groups, and the reducing agents used are different, and the products are also different.
In addition, under basic conditions, reactions such as hydrolysis may occur, and acetyl groups will be attacked by bases, resulting in structural changes. In organic synthesis, it is often used as a key intermediate. With its unique chemical properties, complex organic molecular structures are constructed through a series of reactions, laying the foundation for the creation of new drugs and functional materials.

The synthesis method of 2-acetylbenzothiophene has been known in ancient times, and is described in detail today.
First, benzothiophene is used as the starting material and prepared by Fu-gram acylation reaction. In this reaction, Lewis acid such as anhydrous aluminum trichloride is often used as the catalyst, and acetic anhydride is the acylating agent. In an appropriate solvent such as dichloromethane, the reagent is slowly added to the benzothiophene solution at low temperature, and then the reaction is heated. After the reaction is completed, the pure 2-acetylbenzothiophene can be obtained through hydrolysis, extraction, column chromatography and other steps. This method is relatively simple to operate, and the raw materials are easy to obtain. However, Lewis acid has certain pollution to the environment, and the reaction conditions need to be precisely controlled.
Second, o-aminothiophenol and ethyl acetoacetate are used as raw materials. First, o-aminothiophenol and ethyl acetoacetate are cyclized under acidic conditions to form benzothiophene derivatives, and then the target product can be obtained through specific oxidation and acylation steps. This path step is slightly complicated, but the atomic economy is higher, and it is more friendly to the environment. And the selectivity and yield of the product can be improved by adjusting the reaction conditions.
Third, using thiophene derivatives as raw materials, the structure of benzothiophene is constructed through multi-step reaction, and acetyl groups are introduced. This approach requires precise modification of the thiophene ring, which often involves complex reactions such as halogenation, coupling, and cyclization. Although the synthesis route is long, it can facilitate the diversification of the product structure and is suitable for the preparation of 2-acetylbenzothiophene derivatives with special structures.
The above synthesis methods have their own advantages and disadvantages, and the selection needs to be weighed according to actual needs to achieve the purpose of synthesis.

The price range of 2-acetylbenzothiophene in the market is difficult to determine. The price of this substance often changes for many reasons.
First, the price varies depending on the source of production. If it comes from a large workshop and is well-crafted, the quantity is abundant, and the price may be slightly cheaper; if it is obtained from a small workshop, the production is limited, and the price may be slightly higher.
Second, the situation of market demand also affects the price. If people compete to buy, the demand exceeds the supply, and the price will rise; if there is a lack of demand, the supply exceeds the demand, and the price will decline.
Third, good quality is the key to the price. Those who are of high quality contain very little impurities, pure and flawless, and the price is high; those who are of poor quality, impurities, and the price must be low.
If you taste this thing, the price may be between a few yuan and a few tens of yuan per gram. However, this is only an approximate number, not an exact value. To know the true price, you can only get a near-real price when you consult chemical companies, sell it, or visit the market. And times change, and the price is also impermanent, so if you want an accurate price, you must take real-time news as the criterion.