2-ACETYL-5-CHLOROTHIOPHENE

2-Ethyl-5-nitropyridine is mainly used in the field of pharmaceutical synthesis. This compound has a unique structure and is of great significance in the development of many drugs.
In the development of antibacterial drugs, 2-ethyl-5-nitropyridine can act as a key intermediate. By modifying and modifying its structure, substances with specific antibacterial activities can be prepared. Some new antibacterial drugs have been ingeniously introduced into this structure fragment, which has improved the inhibitory effect on specific pathogenic bacteria, enhanced drug targeting, and reduced the adverse effects on normal cells, providing a new direction for solving the problem of antibacterial drug resistance.
In the field of cardiovascular drug research and development, 2-ethyl-5-nitropyridine also plays an important role. Researchers have found that some compounds involved in its synthesis have regulatory effects on the cardiovascular system. It may be able to stabilize blood pressure and heart rate by affecting ion channels, regulating vascular tension and other mechanisms, providing a key basis for the innovation of cardiovascular disease treatment drugs.
In addition, in the field of neurological drug research, 2-ethyl-5-nitropyridine has also emerged. Using it as a starting material, complex molecular structures with neural activity can be constructed. These molecules may act on neurotransmitter receptors, modulate nerve signaling, and provide potential effective drug lead compounds for the treatment of neurological-related diseases, such as depression and Parkinson's disease.
From this perspective, 2-ethyl-5-nitropyridine, as an important organic synthesis intermediate, has continuously expanded its application boundaries in the field of pharmaceutical synthesis by virtue of its special chemical structure, laying the foundation for the birth of innovative drugs and contributing to the development of human health.

2-% ethyl-5-nitropyridine is one of the organic compounds. Its physical properties are quite unique, let me tell you one by one.
Looking at its appearance, under room temperature and pressure, it is mostly a crystalline solid state, which makes it different in many scenes.
As for the color, it is usually almost colorless to light yellow. This color characteristic may be used as a preliminary basis for discrimination in some chemical reactions and practical applications.
When it comes to the melting point, it is within a certain range, and the specific value may vary slightly according to different purity and measurement conditions. This melting point characteristic is crucial in the separation, purification and related process operations of substances. For example, when using the difference in melting point for mixture separation, this property can be used to achieve effective separation.
In terms of boiling point, there is also a specific value, which reflects the temperature conditions when it changes from liquid to gaseous state when heated. This boiling point value is a key parameter in the operation process involving gas-liquid conversion such as distillation. During operation, the temperature needs to be precisely controlled to reach the boiling point, so as to achieve the separation of different substances.
Solubility is also an important physical property. In common organic solvents, such as ethanol, ether, etc., there is a certain solubility. This solubility characteristic can be used to select a suitable solvent to promote the smooth progress of the reaction when the reaction system of organic synthesis is constructed. For example, if a reaction needs to occur in a homogeneous system, the good solubility of the selected solvent to 2-% ethyl-5-nitropyridine can ensure sufficient contact with the reactants and improve the reaction efficiency. In water, its solubility is relatively limited, and this property can be used in some operations based on the separation of aqueous and organic phases.
In addition, the density of 2-% ethyl-5-nitropyridine also has corresponding values. Although it is often not well known to the public, in chemical production involving material measurement, storage and pipeline transportation, density data is indispensable for accurate calculation of material volume and rational design of equipment.

To prepare 2-ethyl-5-nitropyridine, you can follow the following ancient method.
First take the appropriate pyridine as the starting material. In the case of pyridine, the cyclic nitrogen-containing organic compound also has a specific reactivity of the hydrogen atom on the ring, which can be used to introduce the desired group.
Introduce ethyl to the pyridine ring, and often react with halogenated ethane and pyridine under the catalysis of bases. Bases, such as potassium carbonate, can promote the substitution reaction between the halogen atom of the halogenated ethane and the hydrogen atom at a specific position on the pyridine ring. This process requires attention to the ratio of the reaction temperature to the reactant. If the temperature is too high or the ratio is improper, it can cause a cluster of side reactions. When the reaction is completed, 2-ethylpyridine is obtained.
Then the nitro group is introduced at the 5-position of 2-ethylpyridine. In this step, mixed acid (a mixture of nitric acid and sulfuric acid) is usually used as the nitrifying agent. Under the action of sulfuric acid, nitric acid generates nitroyl cation, which is an electrophilic agent that can attack the 2-ethylpyridine ring. Due to the electronic effect of the nitrogen atom on the pyridine ring, the electron cloud density at a specific position on the 2-ethylpyridine ring is different, and the 5-position is more suitable for the occurrence of electrophilic substitution reactions. However, the mixed acid is highly corrosive and oxidizing. When operating, it is necessary to be cautious and strictly control the temperature to prevent dangerous accidents such as explosions. During the reaction, closely monitor the reaction process, and when the reaction reaches the expected level, through appropriate separation and purification methods, such as extraction, distillation, recrystallization, etc., pure 2-ethyl-5-nitropyridine can be obtained.
This synthesis method, although after years, has clear principles and steps, and is a classic way to prepare 2-ethyl-5-nitropyridine.

Di-ethyl-5-nitroimidazole should be carefully attended to during storage and transportation. This is due to its characteristics, and a little carelessness may cause many adverse consequences.
When storing, the first choice of environment. It should be placed in a cool and dry place, away from fire and heat sources. Because di-ethyl-5-nitroimidazole is easily decomposed by heat, if the storage environment temperature is too high, or its chemical structure changes, it will damage the quality and efficacy. And humid gas can also affect it, or cause deliquescence, so a dry environment is indispensable.
Furthermore, it should be stored separately from oxidants, acids and other substances. The chemical properties of di-ethyl-5-nitroimidazole are active, contact with oxidants, or cause violent reactions, and even the risk of explosion; when coexisted with acids, chemical reactions may also occur, causing deterioration.
As for transportation, it must be strictly implemented in accordance with relevant regulations. The packaging must be sturdy and tight to prevent leakage due to bumps and collisions during transportation. Once leaked, it will not only cause pollution to the environment, but also may endanger the safety of transportation personnel and surrounding people.
Transportation vehicles should also be kept clean to avoid mixing with other impurities. At the same time, pay close attention to changes in temperature and humidity during transportation, and take appropriate measures in a timely manner to maintain the stability of di-ethyl-5-nitroimidazole.
Transportation personnel should also be familiar with the characteristics of di-ethyl-5-nitroimidazole and emergency treatment methods. In case of emergencies, such as leakage, fire, etc., they can respond quickly and correctly to minimize the harm. In this way, the safety and stability of di-ethyl-5-nitroimidazole during storage and transportation can be ensured.

The market price range of 2-% ethylhexyl-5-nitrothiazole varies depending on factors such as market supply and demand, quality, origin, and trading hours.
In the market of medicinal materials, if its quality is high, the source is pure, and when the market demand is strong, the price per catty may reach fifty taels of silver. This price is like a spring flower, dazzling and eye-catching, attracting the attention of many merchants. Because of the excellent quality, it is more effective in medicine dispensing, workshop refining and other uses, so the price is high and the number of people seeking it.
However, if the quality is slightly inferior, or when the market supply is abundant and the demand is slightly reduced, the price may be reduced to twenty taels of silver per catty. This price is just like the residual flowers in autumn. Although it is still valuable, it is not as high as in the peak season. Because of the inferior quality, there may be discounts in the application, so the buyer weighs the pros and cons, and the bid is also reserved.
Or because the origin is remote, the transportation is difficult, resulting in an increase in costs, and the price will rise accordingly, ranging from 30 to 40 taels of silver per catty. This situation is like a rugged mountain road and difficult transportation of goods. Naturally, the price needs to reflect its setbacks.
Furthermore, at different trading hours, such as on the eve of festivals, doctors increase their medication and the demand increases greatly. The price will also rise, or be similar to the high price of high-quality products. In normal times, the price may stabilize and remain around the medium price. Just like the ebb and flow of the tide, the market also fluctuates.
To sum up, the market price of 2-% ethylhexyl-5-nitrothiazole fluctuates between 20 taels of silver per catty and 50 taels of silver per catty.