2 Acetamido Thiophene
quinoline thiophene imidazole thiazole

2-(Acetamido)thiophene

Taiy Chemical

    Specifications

    HS Code

    781459

    Name 2-(Acetamido)thiophene
    Molecular Formula C6H7NOS
    Molecular Weight 141.19
    Appearance White to off - white solid
    Melting Point 127 - 131 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
    Stability Stable under normal conditions, but may react with strong oxidizing agents

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    General Information
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    Frequently Asked Questions

    As a leading 2-(Acetamido)thiophene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2- (Acetamido) thiophene?
    2-%28Acetamido%29thiophene is 2 - (acetamido) thiophene, which has a wide range of uses. In the field of medicine, it is often a key intermediate, which is converted into pharmaceutical active ingredients by specific reactions. Many antibacterial and anti-inflammatory drug synthesis rely on its participation to help improve the efficacy and stability of drugs. In the field of materials science, it can be chemically modified to construct special structural polymers for the preparation of organic Light Emitting Diode (OLED) materials, which endow the materials with excellent photoelectric properties and make the OLED screen display clearer and more colorful. In addition, in organic synthesis chemistry, it is an important building block, participating in the construction of complex organic molecules, expanding the variety and structural diversity of organic compounds, and laying the foundation for the development and performance exploration of new compounds. Chemists can achieve diverse reactions by regulating their reaction conditions and reagent selection, creating compounds with unique functions and properties, providing material support for the development of various fields.
    What are the physical properties of 2- (Acetamido) thiophene?
    2 - (acetamido) thiophene is a kind of organic compound. It has unique physical properties, which are related to the material morphology, melting boiling point, solubility and density.
    Looking at its morphology, under normal temperature and pressure, 2 - (acetamido) thiophene is often white to light yellow crystalline powder, which is easy to observe and operate. As for the melting point, it is between 173 ° C and 177 ° C. This temperature limit allows the substance to melt from solid to liquid under specific conditions, providing a basis for its application in heating technology.
    In terms of solubility, 2 - (acetamido) thiophene is difficult to dissolve in water, which is related to the structure and interaction force of water molecules. However, it is soluble in some organic solvents, such as ethanol, chloroform, etc. Such solubility is of great significance in the process of organic synthesis and separation and purification, and its dissolution, reaction or separation can be achieved with the help of suitable solvents.
    In terms of density, it is about 1.34g/cm ³. This value reflects the mass per unit volume of the substance. In the process of mixing and storage of the substance, the stratification status and space occupied by it with other substances can be considered according to the density.
    The physical properties of 2 - (acetamido) thiophene are crucial in the field of organic synthesis. With the characteristics of melting point, the reaction temperature can be controlled to ensure the smooth progress of the reaction; using solubility, the appropriate solvent can be selected to promote the efficient occurrence of the reaction, or to achieve the purification of the product. The combination of many properties helps chemists to conduct in-depth research and make rational use of this compound.
    Is 2- (Acetamido) thiophene chemically stable?
    2-%28Acetamido%29thiophene is 2- (acetamido) thiophene, which is still stable in physical properties. Looking at its structure, the thiophene ring is aromatic and can maintain a certain degree of stability. Acetamido is connected to the thiophene ring, and the carbonyl group in the acetamido group is conjugated with the amino group, which can disperse the electron cloud and improve the overall stability to a certain extent.
    Under common environmental conditions, if the temperature is not too high and there is no strong oxidation or strong reducing substance intrusion, 2- (acetamido) thiophene can exist in the normal state. In case of high temperature, the vibration of the chemical bond intensifies, or the bond is broken, which triggers decomposition. In the case of strong oxidizing agents, such as potassium permanganate, etc., because of their electron-grabbing ability, the thiophene ring or acetamide group is easily oxidized, resulting in structural damage. In the case of strong reducing agents, such as lithium aluminum hydride, the carbonyl group of the acetamide group may be reduced, changing the structure of the compound.
    In organic synthesis reaction systems, the stability of 2- (acetamide) thiophene varies according to the reaction conditions. Under mild reaction conditions, such as moderate temperature, neutral or weak acid-base environment, the structure can be maintained to participate in the reaction, and the activity of the thiophene ring can be used to achieve specific conversion. However, in strong acid or strong base environments, the amide bond or hydrolysis of the acetamide group can change the structure of the compound.
    In summary, 2 - (acetamido) thiophene has a certain stability, but under extreme conditions or special reagents, its structure is volatile and its stability is broken.
    What are the synthesis methods of 2- (Acetamido) thiophene
    2-%28Acetamido%29thiophene is 2-acetaminothiophene, and its synthesis method is as follows:
    ###With thiophene as the starting material
    1. ** Acetylation reaction **:
    - With thiophene as the substrate, in the presence of a suitable catalyst such as anhydrous aluminum trichloride and other Lewis acids, the Fu-gram acylation reaction occurs with acetyl chloride or acetic anhydride. The electron cloud density of thiophene is high, and under the catalysis of Lewis acid, the acetyl group selectively replaces the hydrogen atom at the 2-position of thiophene. During the reaction, thiophene is dissolved in an inert solvent such as anhydrous dichloromethane, and the dichloromethane solution of acetyl chloride and anhydrous aluminum trichloride is slowly added dropwise at low temperature (such as 0-5 ° C). After the dropwise addition is completed, the reaction is stirred at room temperature for several hours. After the reaction is completed, the reaction mixture is hydrolyzed with dilute hydrochloric acid to dissolve the resulting aluminum salt, and then the liquid is separated. The organic phase is dried with anhydrous sodium sulfate, and the solvent is removed by rotary evaporation to obtain 2-acetylthiophene. < Br > - The reaction mechanism of this step is: Lewis acid (such as\ (AlCl_ {3}\)) interacts with acetyl chloride to enhance the positive electricity of carbonyl carbon of acetyl chloride, thiophene attacks carbonyl carbon as a nucleophilic reagent, forming a carbon-carbon bond, and then loses a proton to generate 2-acetylthiophene.
    2. ** Nitrification reaction **:
    - The resulting 2-acetylthiophene is nitrified. In the mixed acid system of concentrated sulfuric acid and concentrated nitric acid, the nitration reaction of 2-acetylthiophene occurs, and the nitro group mainly enters the 5-position of the thiophene ring (because the 2-acetyl group is the meta-localization group). The reaction is carried out at low temperature (such as 0-10 ℃) to control the reaction rate and selectivity. The 2-acetylthiophene is slowly added to the pre-cooled mixed acid, and the reaction is stirred for a certain time. After the reaction is completed, the reaction solution is poured into ice water, the solid is precipitated, and the 2-acetyl-5-nitrothiophene is filtered to obtain. < Br > - The reaction mechanism is as follows: the nitric acid in the mixed acid generates nitroyl cation (\ (NO_ {2 }^{+}\)), as an electrophilic reagent to attack the 5-position of 2-acetylthiophene to form an intermediate, and then lose a proton to generate 2-acetyl-5-nitrothiophene.
    3. ** Reduction reaction **:
    - 2-acetyl-5-nitrothiophene is reduced with suitable reducing agents such as iron powder and hydrochloric acid, zinc powder and hydrochloric acid or hydrogen and catalysts (such as palladium carbon). Taking iron powder and hydrochloric acid as an example, 2-acetyl-5-nitrothiophene and excess iron powder are added to the hydrochloric acid solution to heat the reflux reaction. Iron is oxidized to ferrous ions under acidic conditions, while nitro is reduced to amino groups to generate 2-acetyl-5-aminothiophene. After the reaction is completed, the iron mud is filtered to remove, and the filtrate is neutralized with sodium hydroxide solution to alkaline, and the solid is precipitated. The product is obtained by filtration. < Br > - If hydrogen and palladium carbon are used for catalytic reduction, in a suitable solvent (such as ethanol), 2-acetyl-5-nitrothiophene and palladium carbon catalysts are added, hydrogen is introduced, and the reaction is carried out at a certain pressure and temperature. Hydrogen is adsorbed and activated on the surface of palladium carbon, and the nitro group is gradually reduced to an amino group.
    4. ** Acetylation (aminoacetylation) **:
    - The resulting 2-acetyl-5-aminothiophene is reacted with acetic anhydride in the presence of a basic catalyst such as pyridine, and the amino group is acetylated to obtain 2-acetaminothiophene. Dissolve 2-acetyl-5-aminothiophene in pyridine, add an appropriate amount of acetic anhydride, and stir the reaction at room temperature for several hours. After the reaction, pour the reaction solution into water, adjust the pH to acidic with dilute hydrochloric acid, precipitate the solid, filter, wash, and dry to obtain the target product 2-acetaminothiophene.
    ###Other synthetic pathways
    There are also literature reports that 2-halothiophene is used as the starting material, and the nucleophilic substitution reaction occurs with the metal salt of acetamide group (such as lithium acetamide, etc.), and the acetamide group is directly introduced to obtain 2-acetaminothiophene. However, this method requires harsh reaction conditions, and the preparation of raw materials is relatively complicated. It is not as widely used as the above-mentioned method using thiophene as the starting material.
    What is the price range of 2- (Acetamido) thiophene in the market?
    2-%28Acetamido%29thiophene is 2-acetaminothiophene. The price of this product in the market is often changed due to differences in quality, source and purchase quantity.
    In the place where chemical raw materials are traded, if the purchase quantity is small, it is only used for experimental investigation, and its price per gram may be in the tens of yuan. The cover is prepared or requires more complex processes, and there are also costs for raw materials and purification.
    If it is purchased in bulk and used in industrial production and other ways, due to economies of scale, the unit price should drop. If the purchase quantity reaches several kilograms or more, the price per gram may be reduced to several yuan.
    However, this is only a rough guess. Nowadays, the chemical market is volatile, and the price of raw materials, supply and demand can all affect its selling price. To know the exact price, you need to consult the chemical product supplier, or check the recent quotation on the chemical trading platform to get an accurate number.