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What is the chemical structure of 2- (5-Iodo-2-Methylbenzoyl) -5- (4-Fluorophenyl) Thiophene?
This is an organic compound, and its name is 2- (5-iodine-2-methylbenzoyl) -5- (4-fluorophenyl) thiophene. Looking at its naming, its chemical structure can be deduced according to the rules of organic chemistry.
"2- (5-iodine-2-methylbenzoyl) ", it can be known that there is a benzoyl group, which is connected to the main structure at the 2 position of the benzene ring, and the 5 position of the benzene ring has an iodine atom and a methyl group at the 2 position. "5- (4-fluorophenyl) thiophene" indicates that the 5 position of the thiophene ring is connected with 4-fluorophenyl.
Thiophene is a sulfur-containing five-membered heterocycle with aromatic properties. In this compound, the thiophene ring is connected to 5-iodine-2-methylbenzoyl at one end and 4-fluorophenyl at the other end. In benzoyl, carbonyl (C = O) is connected to the benzene ring to form a conjugated system. In 5-iodine-2-methylbenzoyl, the iodine atom has a large atomic radius and electronegativity, which affects the distribution and spatial structure of the molecular electron cloud; methyl is the power supply subgroup, which can increase the electron cloud density of the benzene ring. 4-Fluorophenyl, fluorine atoms also have electronegativity, which affects the electron cloud of the benzene ring.
In general, the chemical structure of 2- (5-iodo-2-methylbenzoyl) -5- (4-fluorophenyl) thiophene is composed of a specific substituent linked to a thiophene ring, and the interaction of each substituent determines the physical and chemical properties of this compound.
What are the main uses of 2- (5-Iodo-2-Methylbenzoyl) -5- (4-Fluorophenyl) Thiophene?
2-%285-Iodo-2-Methylbenzoyl%29-5-%284-Fluorophenyl%29Thiophene, this is an organic compound. Its main uses are quite extensive and it plays a crucial role in the field of medicinal chemistry.
In the development of drugs, this compound is often used as a lead compound. Because of its unique chemical structure, it can interact with specific biological targets. For example, in the study of anti-tumor drugs, its structure can be modified to optimize the binding affinity with tumor cell-related proteins, so as to inhibit tumor cell growth and proliferation. Or in the development of drugs for neurological diseases, it is expected to regulate neurotransmitter-related targets, providing the possibility of treating difficult diseases such as Alzheimer's disease and Parkinson's disease.
In the field of materials science, it also has its application. Because it contains specific functional groups, it can participate in material synthesis reactions. For example, in the preparation of organic optoelectronic materials, it can adjust the electron transport properties and optical properties of materials. Introducing it into the conjugated polymer system may improve the luminous efficiency and stability of the polymer, so that it can be applied to organic Light Emitting Diode (OLED) and other optoelectronic devices to improve the performance and service life of the device.
In addition, in the field of organic synthetic chemistry, this compound can participate in the construction of many complex organic molecules as a key intermediate. With its structural characteristics, a series of compounds with diverse structures can be derived through a variety of organic reactions, such as nucleophilic substitution, coupling reactions, etc., which contribute to the development of organic synthetic chemistry and help scientists explore more novel organic compound structures and properties.
What are the synthesis methods of 2- (5-Iodo-2-Methylbenzoyl) -5- (4-Fluorophenyl) Thiophene?
To prepare 2 - (5 - iodine - 2 - methylbenzoyl) - 5 - (4 - fluorophenyl) thiophene, the method of organic synthesis is often followed. The first method is to start with 5 - iodine - 2 - methylbenzoic acid, and first make it react with appropriate reagents to convert into acid chloride. For example, by co-heating with thionyl chloride, 5 - iodine - 2 - methylbenzoyl chloride can be obtained. This acid chloride is reactive and can react with 5- (4-fluorophenyl) thiophene in the presence of a suitable base, such as triethylamine, in an inert solvent, such as dichloromethane, and obtain the target product by nucleophilic substitution.
Second, with 2-methyl-5-iodobenzaldehyde as the starting material, the carbon chain is increased and the desired acyl structure fragment is introduced by means of Wilsmeier-Hack reaction, and then with sulfur-containing reagents and 4-fluorophenyl-related reagents, through a series of cyclization and condensation reactions, the thiophene ring is gradually constructed and 4-fluorophenyl is introduced, and the final product is 2 - (5-iodo- 2-methylbenzoyl) -5 - (4-fluorophenyl) thiophene. During the reaction, it is necessary to pay attention to the control of reaction conditions, such as temperature, pH, reaction time, etc., which are all related to the yield and purity of the product. And the purity and dosage of the reagents used are also key. When accurately measured, it is necessary to achieve the best synthesis.
What are the physical properties of 2- (5-Iodo-2-Methylbenzoyl) -5- (4-Fluorophenyl) Thiophene?
2-% (5-iodo-2-methylbenzoyl) -5- (4-fluorophenyl) thiophene, an organic compound. This compound has specific physical properties, so let me tell you one by one.
Looking at its appearance, it is often in the state of a crystalline solid, with a fine texture and a regular crystalline morphology. This is due to the orderly arrangement of intermolecular forces. Its melting point is quite important, and has been experimentally determined to be within a certain temperature range. The level of melting point depends on the strength of intermolecular interactions, such as Van der Waals force and hydrogen bonds.
Solubility is also a key property. In organic solvents, such as common chloroform and dichloromethane, its solubility is relatively considerable. Due to the fact that such organic solvents can form similar interactions with the molecules of the compound, it conforms to the principle of "similar miscibility". However, in water, its solubility is extremely low, because the polarity of water is quite different from the structure of the compound, it is difficult to form an effective interaction.
Furthermore, its density is also a characteristic. After precise measurement, its density value can be obtained. Density reflects the degree of close packing of substances and molecules, which is related to molecular structure, molecular weight and other factors.
In addition, the stability of the compound cannot be ignored. Under normal environmental conditions, it can maintain chemical structure stability for a certain period of time. In case of extreme conditions such as high temperature, strong acid, and strong base, its structure may change, triggering chemical reactions.
Spectral properties are also important characterizations. Infrared spectroscopy can show the vibration absorption peaks of characteristic functional groups, thereby confirming the existence of functional groups such as benzene rings, carbonyl groups, and thiophene rings. Nuclear magnetic resonance spectroscopy can provide information on the chemical environment of hydrogen and carbon atoms in molecules, which can help to analyze molecular structures.
The physical properties of this 2-% (5-iodine-2-methylbenzoyl) -5- (4-fluorophenyl) thiophene are of great significance in the fields of organic synthesis and drug development. Researchers can conduct in-depth investigations and applications based on this.
What is the market outlook for 2- (5-Iodo-2-Methylbenzoyl) -5- (4-Fluorophenyl) Thiophene?
There are currently 2 - (5 - iodine - 2 - methylbenzoyl) - 5 - (4 - fluorophenyl) thiophene, which is worth exploring in the market prospect.
Looking at the field of pharmaceutical and chemical industry, such thiophene derivatives containing specific substituents often have unique biological activities. The combination of 5 - iodine - 2 - methylbenzoyl and 4 - fluorophenyl may make the compound exhibit affinity for specific biological targets and can be used as a potential lead compound in the field of drug development. Nowadays, the demand for innovative drugs is eager, and molecules with novel structures and activities are in high demand. Due to the unique structure of this compound, it has found an opportunity in the process of anti-inflammatory, anti-tumor and other drug creation, and the market potential cannot be underestimated.
Furthermore, in the field of materials science, substances containing thiophene structures often have excellent photoelectric properties due to the existence of conjugated systems. 2 - (5-iodo- 2-methylbenzoyl) - 5 - (4-fluorophenyl) thiophene or its photoelectric properties are optimized due to the electronic effect of substituents. With the rapid development of organic electronics, there is a growing demand for new optoelectronic materials in fields such as organic Light Emitting Diodes (OLEDs) and organic solar cells. If this compound can emerge in terms of improving device efficiency and stability, it will definitely be able to gain a share of the material market.
However, the road of its marketing activities is not smooth. The complexity of the synthesis process may lead to high production costs, limiting its large-scale production and application. And the market competition is fierce, and it is necessary to compete with similar compounds. Only by developing efficient synthesis routes, reducing costs, and deeply exploring its performance advantages can it stand out in the market and open up broad prospects.