What is the chemical structure of 2- [4- [ (methylsulfonyl) oxy] phenyl] -Benzo [b] thiophene-6-ol 6-methanesulfonate

This is the name of an organic compound. To clarify its chemical structure, it is necessary to follow the rules of organic chemistry. "2 - [4 - [ (methylsulfonyl) oxy] phenyl] - Benzo [b] thiophene - 6 - ol 6 - methanesulfonate" can be disassembled and analyzed step by step.

"Benzo [b] thiophene", which is the basic structure of benzo [b] thiophene, is formed by fusing the benzene ring with the thiophene ring. " 2 - [4- [ (methylsulfonyl) oxy] phenyl] ", indicating that at position 2 of benzo [b] thiophene, there is a substituent connected, and this substituent is 4- [ (methylsulfonyl) oxy] phenyl, that is, position 4 of the benzene ring is connected with methanesulfonyl oxide." 6-ol "means that there is a hydroxyl group at position 6 of benzo [b] thiophene." 6-methanesulfonate "means that the hydroxyl group at position 6 forms a sulfonate with methanesulfonic acid.

To sum up, the structure of this compound is based on benzo [b] thiophene as the parent nucleus, with a benzene ring substituent containing methanesulfonyloxy group at position 2, and a hydroxyl group at position 6 forming an ester of methanesulfonic acid. Its chemical structure is modified from the core structure of benzo [b] thiophene combined with the substituents and functional groups at specific positions. In this way, the overall chemical structure of this compound can be obtained.

What are the physical properties of 2- [4- [ (methylsulfonyl) oxy] phenyl] -Benzo [b] thiophene-6-ol 6-methanesulfonate

2-%5B4-%5B%28methylsulfonyl%29oxy%5Dphenyl%5D - Benzo%5Bb%5Dthiophene - 6 - ol 6 - methanesulfonate, which is an organic compound. In terms of physical properties, it is mostly solid at room temperature and pressure. Due to the intermolecular force, the molecules are closely arranged with each other, giving it a relatively stable solid structure.

Looking at its solubility, due to the polar sulfonate group and methanesulfonyl group in the molecule, in polar solvents such as methanol and ethanol, it can exhibit a certain solubility by virtue of the hydrogen bond and dipole-dipole interaction with the solvent molecules. In non-polar solvents such as n-hexane and benzene, due to the large difference between molecular polarity and solvent polarity, it follows the principle of "similar miscibility", and the solubility is extremely low.

When it comes to the melting point, due to the interaction of aromatic rings, heterocycles and various functional groups in the molecular structure, a relatively stable lattice structure is formed. The destruction of this structure requires high energy, so the melting point may be higher. The specific value is determined by factors such as the precise structure of the molecule and the crystalline morphology.

As for the boiling point, in view of its solid state characteristics and strong intermolecular forces, it is necessary to provide a lot of energy to overcome the attractive forces between molecules, so the boiling point is also quite high. And during the heating process, or due to the complex molecular structure, chemical reactions such as decomposition may have occurred before reaching the boiling point.

The physical properties of this compound are of great significance in the fields of organic synthesis and drug development. In organic synthesis, its solubility allows chemists to select suitable solvents to optimize reaction conditions; melting point and boiling point data provide key references for the separation and purification process, helping them to accurately control temperature and other conditions to obtain high-purity products.

What is the synthesis method of 2- [4- [ (methylsulfonyl) oxy] phenyl] - Benzo [b] thiophene-6-ol 6-methanesulfonate

The method of synthesizing 2- [4- [ (methylsulfonyl) oxy] phenyl] -benzo [b] thiophene-6-alcohol 6-methylsulfonate is quite complicated, and it is necessary to follow specific steps according to the principle of organic synthesis.

First, the required raw materials need to be prepared, such as benzo [b] thiophene derivatives containing corresponding substituents, methylsulfonyl chloride and other reagents. The starting materials should have suitable activity check points to facilitate subsequent reactions.

First, the benzo [b] thiophene derivative is in an appropriate solvent, and under the catalysis of the base, the nucleophilic substitution reaction occurs with methylsulfonyl chloride. The key to this step lies in the choice of solvent, which needs to consider its solubility to the reactants and its impact on the reaction process. Commonly used solvents may be dichloromethane, N, N-dimethylformamide, etc. The type and dosage of bases are also very important. Common bases such as triethylamine and potassium carbonate need to be precisely controlled to make the reaction happen smoothly and avoid the growth of side reactions. In this reaction, the specific position of the benzo [b] thiophene derivative interacts with methylsulfonyl chloride to introduce the [ (methylsulfonyl) oxy] group.

Then, another key step is to introduce a specific phenyl group into the product. This may require coupling reactions catalyzed by transition metals, such as Suzuki coupling, Stille coupling, etc. Taking Suzuki coupling as an example, suitable palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., should be selected with corresponding bases and ligands. The ratio of reactants, reaction temperature and time need to be strictly controlled. In this process, a benzo [b] thiophene derivative containing [ (methylsulfonyl) oxy] is coupled with a specific phenylboronic acid or its ester compound to form a 2 - [4 - [ (methylsulfonyl) oxy] phenyl] -benzo [b] thiophene structure.

Finally, the hydroxy group of benzo [b] thiophene-6 - position is esterified with methanesulfonate. The resulting product is reacted with methanesulfonyl chloride in the presence of a base, which can be selected as pyridine or the like. Whether this reaction condition is mild or not depends on the purity and yield of the final product. Through this series of reactions, carefully controlling the conditions of each step, the target product 2 - [4- [ (methylsulfonyl) oxy] phenyl] -benzo [b] thiophene-6-alcohol 6-methanesulfonate can be obtained. After each step of the reaction, the product is often purified by means of column chromatography and recrystallization to ensure the accuracy of the reaction and the purity of the product.

What are the application fields of 2- [4- [ (methylsulfonyl) oxy] phenyl] - Benzo [b] thiophene-6-ol 6-methanesulfonate

2-%5B4-%5B%28methylsulfonyl%29oxy%5Dphenyl%5D+-+Benzo%5Bb%5Dthiophene-6-ol+6-methanesulfonate, this is an organic compound. Its application field is quite extensive. In the field of medicinal chemistry, it is often used as a key intermediate for active pharmaceutical ingredients. After specific chemical reactions and transformations, molecular structures with specific biological activities can be constructed to meet the needs of drug research and development.

In the field of materials science, it may be used to synthesize materials with special photoelectric properties. Because of its unique chemical structure, it may endow materials with specific properties such as fluorescence and conductivity, showing potential application value in organic Light Emitting Diode (OLED), organic solar cells and other fields.

In the field of organic synthetic chemistry, the compound can be used as an important synthetic building block due to its diverse functional groups in its structure. Chemists use various organic reactions as starting materials to expand and construct more complex organic molecular structures, contributing to the development and innovation of organic synthesis methodologies.

Or in the field of fine chemicals, it is used as a special additive. With its unique chemical properties, it may improve product performance, such as enhancing product stability and enhancing its specific functions, etc., contributing to the improvement of the quality of fine chemical products. In short, this compound has potential applications that cannot be ignored in many scientific and industrial fields.

2- [4- [ (methylsulfonyl) oxy] phenyl] - Benzo [b] thiophene-6-ol 6-methanesulfonate

Guanfu 2 - [4 - [ (methylsulfonyl) oxy] phenyl] - Benzo [b] thiophene - 6 - ol 6 - methanesulfonate is quite complex and multi-faceted in terms of market prospects.

Bearing the brunt of the research, it is in the field of scientific research because of its unique chemical structure, or it is important for researchers in the fields of organic synthesis and medicinal chemistry. Its special functional group combination may provide novel ideas for the creation of new compounds, and it is expected to give rise to molecules with unique biological activities, which will explore new paths in drug research and development. Therefore, there may be potential needs and application opportunities at the forefront of scientific research.

Furthermore, in the pharmaceutical industry, if its biological activity is confirmed by in-depth research, and it has good pharmacokinetic properties, it may become a drug lead compound. After rational structure optimization and development, it may be converted into clinically usable drugs to deal with specific diseases, thus opening up a broad pharmaceutical market.

However, it is also necessary to be clear that the acceptance and promotion of the market is not smooth. The synthesis process of this compound may be difficult, and cost control is a key challenge. If the synthesis process cannot be effectively optimized and the production cost is reduced, its large-scale production and market popularization will be hindered. And the road to new drug research and development is long, and it needs to go through strict pharmacological, toxicological and clinical trials, which is quite risky.

And market competition is also a factor that cannot be ignored. If compounds of the same structure or function have already occupied the market first, to stand out, they need to demonstrate significant advantages, such as better curative effect and fewer side effects.

In summary, 2 - [4 - [ (methylsulfonyl) oxy] phenyl] - Benzo [b] thiophene - 6 - ol 6 - methanesulfonate has attractive prospects for potential applications in scientific research and medicine. To truly emerge in the market, it is still necessary to overcome many difficulties and obstacles such as synthesis costs, R & D risks and market competition. Its prospects are bright and challenges coexist.