2-(4-fluorophenyl)thiophene 58861-48-6

2-%284-fluorophenyl%29thiophene, its CAS number is 58861-48-6, which is an important raw material in the field of organic synthesis. According to the past books, its uses are quite wide.
In the field of materials science, it is often a key component in the preparation of advanced optoelectronic materials. Due to its unique electronic structure and optical properties, the compound can effectively improve the electrical conductivity and luminous efficiency of materials. Therefore, it is highly relied on in the manufacture of organic Light Emitting Diodes (OLEDs) and organic photovoltaic cells. Taking OLEDs as an example, adding an appropriate amount of 2-%284-fluorophenyl%29thiophene can optimize the color purity and brightness of the device and improve the display effect.
It also has traces in the field of medicinal chemistry. Due to its structural properties, it can provide a novel framework for the design of drug molecules, which helps to develop compounds with specific biological activities. Past studies have shown that compounds derived from this basis have potential affinity and inhibitory activity for specific disease targets, opening up a path for the creation of new drugs.
Furthermore, in the fine chemical industry, 2-%284-fluorophenyl%29thiophene often used as an intermediate for the synthesis of special functional chemicals. Through various chemical reactions, its structure can be modified and expanded to prepare fine chemicals that meet different industrial needs, such as high-performance coatings, special plastic additives, etc., to improve the performance and quality of products.

2-%284-fluorophenyl%29thiophene, its CAS number is 58861-48-6, and this substance has the following physical properties.
In appearance, it often appears as a solid or liquid state, depending on specific environmental conditions such as temperature and pressure. If it is in a suitable temperature range, it may exist in a relatively stable solid form, the appearance may be similar to fine crystalline particles, the surface has a certain gloss, and it can be slightly reflected under light.
In terms of melting point and boiling point, the melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point of this substance has a specific value, which plays a key role in its phase change at different temperatures. When the temperature gradually rises to the melting point, it will begin to melt from a solid state to a liquid state. The boiling point is the temperature at which a substance changes from liquid to gaseous under a specific pressure. The boiling point of the substance determines the temperature at which it will completely vaporize.
In terms of solubility, it varies in different solvents. In organic solvents, such as common ethanol, acetone, etc., it may have a certain solubility. In ethanol, the solubility may increase with the increase of temperature, showing partial dissolution or complete dissolution. After dissolution, the solution may be clear and transparent, or it may be slightly colored. However, in water, its solubility may be low, and it may only be slightly soluble or even insoluble. After adding water, it may be suspended as tiny particles to form a suspension. After a period of time, the particles may gradually settle to the bottom of the water.
Density is also one of the important physical properties, which reflects the mass of the substance per unit volume. The density of this substance determines its stratification when mixed with other substances, etc. If mixed with liquids with less density than it, it may sink to the bottom; if mixed with liquids with greater density than it, it will float to the upper layer.
In addition, its refractive index also has specific values, and the refractive index can be used to identify the purity of the substance. When light passes through the substance, refraction will occur. By measuring the refractive index, the purity and structure of the substance can be known, providing an important basis for further research and application.

2-%284-fluorophenyl%29thiophene, its CAS number is 58861-48-6. This compound is an organic compound with specific chemical properties.
Looking at its structure, it contains a thiophene ring and a 4-fluorophenyl group. The thiophene ring is a five-membered heterocyclic ring with aromaticity and good stability. It can participate in various chemical reactions, such as electrophilic substitution reaction, and can introduce other functional groups at specific positions on the ring. The fluorine atom in the 4-fluorophenyl group has high electronegativity and will affect the distribution of molecular electron clouds.
In terms of physical properties, because the molecular structure contains aromatic rings, it is speculated that its solubility in organic solvents may be better, and the melting boiling point may be affected by intermolecular forces such as van der Waals force and π-π stacking.
In terms of chemical activity, the electrophilic substitution activity of thiophene ring is higher, and the electron-absorbing effect of fluorine atom may reduce the electron cloud density of benzene ring, and the electrophilic substitution reaction activity may be different from that of thiophene ring. At the same time, this compound may be used as a synthetic intermediate to construct more complex organic molecular structures, which may have potential applications in the fields of materials science and medicinal chemistry. In the field of materials, or because of its conjugated structure, it is used to prepare optoelectronic materials; in pharmaceutical chemistry, or because of the interaction of specific structures with biological targets, it is used as a lead compound for drug development.

To prepare 2 - (4 - fluorophenyl) thiophene (CAS No.: 58861 - 48 - 6), the synthesis methods can be as follows.
First, 4 - fluorophenylboronic acid and 2 - bromothiophene are used as raw materials and can be obtained by Suzuki coupling reaction. This reaction requires a palladium catalyst, such as tetra (triphenylphosphine) palladium (0), in an alkaline environment. Common bases such as potassium carbonate, sodium carbonate, etc., and the solvent can be a mixed system of dioxane, toluene and water. At the time of the reaction, 4-fluorophenylboronic acid and 2-bromothiophene are coupled with aryl groups under the catalysis of palladium to form the target product 2- (4-fluorophenyl) thiophene.
Second, 4-fluoroacetophenone can be started. First, 4-fluoroacetophenone is reacted with thioacetic acid to obtain the corresponding thioacetylated product. Then hydrolyzed under alkaline conditions, and then dehydrated and cyclized to obtain 2- (4-fluorophenyl) thiophene. In this process, the hydrolysis step requires a suitable base, such as sodium hydroxide; the cyclization step requires appropriate reaction conditions to promote the formation of intramolecular cyclization to form thiophene rings. < Br >
Or, using 4-fluorobenzyl halide and thiophene-2-boronic acid as raw materials, through a similar coupling reaction, this purpose can also be achieved. This reaction also requires suitable catalysts and bases. The reaction conditions are similar to those of Suzuki coupling reaction, but the specific reaction parameters, such as temperature, time, etc., may vary due to differences in raw material activity. All kinds of synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, the difficulty of reaction conditions, yield and purity requirements, and choose the best one.

The question you are asking is about the market price range of 2 - (4 - fluorophenyl) thiophene (CAS No. 58861 - 48 - 6). However, such information is difficult to determine immediately. The market price often fluctuates due to a variety of factors, such as the cost of raw materials, the status of supply and demand, the production process, the quality of quality, and regional differences.
In the past, the works of "Tiangong Kaiwu" all covered the methods and uses of various creations, but did not involve the price of this product. If you want to know the price of this product today, you can explore it from many sources. First, inquire about chemical raw material suppliers, who often know the recent price market; second, visit the chemical product trading platform, which gathers a lot of buying and selling information, or can observe its price range; third, refer to industry reports and information, which may have analysis and statistics on the price of the product.
However, because it is not personally involved in market survey, it is difficult to specify its price range. You should personally explore and collect information to obtain a more accurate price range to meet your needs.