What are the main uses of 2- (2-nitrovinyl) thiophene?
2-% 282 - nitrovinyl%29thiophene, Chinese name 2 - (2 - nitrovinyl) thiophene, this substance is widely used. In the field of organic synthesis, it is often a key intermediate. Due to its special structure, containing thiophene ring and nitrovinyl group, many complex organic compounds can be constructed by various chemical reactions.
For example, in the construction of conjugated system compounds, 2 - (2 - nitrovinyl) thiophene can participate in the reaction, expand the conjugated structure, and enhance the optical and electrical properties of the compounds, which is of great significance for the preparation of optoelectronic materials. In the synthesis of many organic Light Emitting Diode (OLED) materials, this material will be used as the starting material, and the product with specific luminescence properties will be obtained through multi-step reaction.
Furthermore, in the field of medicinal chemistry, the substance also has potential applications. Due to its unique chemical structure, it may interact with specific targets in organisms. Scientists can modify its structure to explore bioactive lead compounds, laying the foundation for the development of new drugs.
In the field of materials science, 2 - (2-nitrovinyl) thiophene can be polymerized to prepare functional polymer materials. Such materials may have special electrical, optical and adsorption properties, and show application potential in sensors, separation membranes and other fields. Such as the preparation of sensors with high sensitivity to specific substances, to achieve rapid detection of specific pollutants or biomarkers in the environment.
What are the physical properties of 2- (2-nitrovinyl) thiophene?
2-% 282 - nitrovinyl%29thiophene, that is, 2 - (2 - nitrovinyl) thiophene, is an organic compound with specific physical properties.
It is mostly solid at room temperature. Due to factors such as intermolecular forces, the melting boiling point has a specific range. The melting point is about 58 - 62 ° C. In this temperature range, the substance changes from solid to liquid. The boiling point is affected by conditions such as gas pressure. Under normal pressure, or in a certain temperature range, boiling occurs liquid-gas phase transformation.
2 - (2 - nitrovinyl) thiophene often shows a light yellow to yellow crystalline powder in appearance. This color is related to the electron transition and conjugation system in the molecular structure. The conjugated system can absorb specific wavelengths of visible light, causing it to exhibit corresponding colors.
The solubility of this compound also has characteristics, and it is difficult to dissolve in water. Water is a solvent with strong polarity, while the polarity of 2 - (2 - nitrovinyl) thiophene molecules is weak, and according to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, N, N - dimethylformamide (DMF), etc. In dichloromethane, because dichloromethane has a certain polarity and can form a certain interaction with 2 - (2 - nitrovinyl) thiophene molecules, it can be dissolved.
In addition, its density may be different from that of water, and the specific value depends on the precise measurement conditions. The density is related to the way of molecular packing and the relative molecular mass. The relative molecular mass is large and the molecular packing is close, so that its density may be different from that of common solvents and water.
These physical properties are of great significance for their applications in organic synthesis, materials science and other fields. For example, in organic synthesis, according to its melting point and solubility, suitable reaction solvents, separation and purification methods can be selected; in material preparation, its color, density and other properties may affect the optical and physical properties of materials.
What are the chemical properties of 2- (2-nitrovinyl) thiophene?
2 - (2-nitrovinyl) thiophene, an organic compound with interesting chemical properties.
Looking at its structure, thiophene is cyclic with 2-nitrovinyl, which gives it unique reactivity. In terms of electronic effect, the nitro group is a strong electron-absorbing group, which is conjugated with the vinyl group, resulting in a decrease in the density of the double-bond electron cloud. In this way, the compound is more susceptible to attack by nucleophiles and is active in nucleophilic addition reactions.
Taking the nucleophilic addition reaction as an example, if a nucleophilic reagent is encountered, such as alcohols, amines, etc., the nucleophilic site of the reagent is easily connected to the β-carbon of the double bond, and then the double bond is broken to form a new carbon-heteroatomic bond. In this process, the electron-absorbing properties of the nitro group stabilize the reaction intermediate and promote the reaction.
Furthermore, its π-conjugate system affects its optical properties. Due to the increase in the degree of conjugation, the compound has significant absorption in the ultraviolet-visible region and can assume a specific color. And the conjugated system makes the intramolecular charge transfer easier, and may have potential applications in the field of optoelectronic materials, such as the production of organic Light Emitting Diodes, solar cell materials, etc.
In terms of thermal stability, due to the interaction of intra-molecular conjugates and nitro groups, the structure can be maintained under moderate heating. However, when the temperature is too high, the nitro group may initiate a decomposition reaction, resulting in the destruction of the molecular structure.
The chemical properties of 2 - (2-nitrovinyl) thiophene are determined by its structure, and it shows potential application value in organic synthesis, materials science and other fields. It can be modified by various reactions to meet different needs.
What are the synthesis methods of 2- (2-nitrovinyl) thiophene
2-% (2-nitrovinyl) thiophene, that is, 2 - (2-nitrovinyl) thiophene, is synthesized as follows:
It can be synthesized by thiophene derivatives and nitrovinyl-containing reagents through a suitable chemical reaction. A common route is to use Knoevenagel condensation reaction. In this reaction, thiophene formaldehyde reacts with similar reagents such as nitroacetic acid in the presence of an appropriate catalyst.
Catalysts can usually be selected from organic bases such as pyridine and its derivatives. The reaction system needs to be carried out in a suitable temperature and solvent environment. For example, under the catalysis of pyridine, thiophene formaldehyde and nitroacetic acid are condensed between the two molecules under anhydrous ethanol as a solvent under mild heating conditions. The carboxyl group in nitroacetic acid dehydrates and condensates with the aldehyde group of thiophene formaldehyde, thereby introducing a 2-nitrovinyl structure at the 2-position of thiophene to generate 2- (2-nitrovinyl) thiophene.
Another possible synthesis strategy is to use the Wittig reaction. React thiophene formaldehyde with a suitable phosphorus ylide reagent. Phosphorus ylide reagents can be prepared by reacting halogenated hydrocarbons with triphenylphosphine and then treated with bases. The halogenated hydrocarbons need to contain nitrovinyl structural fragments. When the phosphorus ylide reagent meets thiophene formaldehyde, a Wittig reaction occurs. The carbon negative ions in the phosphorus ylide reagent perform nucleophilic addition to the aldehyde group of thiophene formaldehyde, and then eliminate triphenylphosphine oxide to form a carbon-carbon double bond, and finally construct the structure of 2- (2-nitrovinyl) thiophene. During the reaction process, attention should be paid to the control of reaction conditions, such as reaction temperature, solvent selection, and ratio of reactants, to ensure that the reaction can be carried out efficiently and selectively, and the yield and purity of the target product can be improved.
What is the price range of 2- (2-nitrovinyl) thiophene in the market?
In today's world, it is not easy to know the price range of 2 - (2 - nitrovinyl) thiophene in the market. The market conditions are fickle, and the price also changes with many factors. Its price may be determined by the cost of raw materials. If the raw materials are rare or high, the price of this compound will also rise. The difficulty of the production process and the amount of output have a great impact on the price. If the process is complicated and the output is scarce, the price will be high.
Furthermore, the market supply and demand situation is the key. If the demand is strong and the supply is insufficient, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop. And different regions and different suppliers, prices are also uneven.
Although there is no conclusive price range to report, if you want to know the details, you can consult the chemical raw material supplier or explore it on the chemical trading platform. Both of these can obtain more real-time and accurate price information, indicating the current market price of 2- (2-nitrovinyl) thiophene.