2-(2'-NITROANILINE)-3-CYANO-5-METHYL THIOPHENE

2-%282%27-NITROANILINE%29-3-CYANO-5-METHYL+THIOPHENE is 2 - (2 '-nitroaniline) -3 -cyano-5 -methylthiophene, which is mostly used in organic synthesis and medicinal chemistry.
In the field of organic synthesis, it often acts as a key intermediate. Due to the unique activity and reaction characteristics of thiophene ring, cyano group and nitroaniline structure, many chemical reactions, such as nucleophilic substitution, coupling reaction, etc., can be derived from organic compounds with more complex structures and functions. For example, through nucleophilic substitution reaction, specific atoms on thiophene ring can react with other nucleophilic reagents, thereby introducing new functional groups, expanding and modifying molecular structure, laying the foundation for the synthesis of organic materials with specific properties.
In the field of medicinal chemistry, it also plays an important role. The unique chemical structure of such compounds may endow them with potential biological activities. Researchers can conduct in-depth research based on this, and develop new drugs with specific pharmacological effects by optimizing and modifying their structures. For example, by adjusting the types and positions of substituents, changing the physical and chemical properties and biological activities of compounds, screening lead compounds with high affinity and selectivity for specific disease targets, and then promoting the development of innovative drugs. In short, 2 - (2 '-nitroaniline) -3 -cyano-5 -methylthiophene has shown broad application prospects in the field of organic synthesis and pharmaceutical research and development, and is of great significance to the development of related fields.

2-%282%27-NITROANILINE%29-3-CYANO-5-METHYL+THIOPHENE that is, 2- (2 '-nitroanilino) -3 -cyano-5 -methylthiophene, there are several common methods for synthesizing this compound.
First, the compound containing thiophene structure is used as the starting material. First, the thiophene derivative is introduced into the cyanyl group at a specific position under suitable reaction conditions. This process can use the nucleophilic substitution reaction, using the cyanyl negative ion as the nucleophilic reagent, and reacting with the suitable leaving group on the thiophene ring to access the cyanyl group. Subsequently, through the appropriate nitrification reaction, the nitro group is introduced at a specific position on the aromatic ring. This step requires strict control of the reaction conditions. Due to the high activity of the nitrification reaction, it is easy to produce polynitro substitution by-products. Next, the nitro group is converted into an amino group by an amination reaction, which is often achieved by a reduction reaction, such as using iron powder, hydrochloric acid system or catalytic hydrogenation. Finally, the generated amino group is reacted with a suitable halogen or other electrophilic reagent, and the 2-nitroaniline moiety is introduced to obtain the target product.
Second, aniline derivatives can also be obtained. First, the aniline is nitrogenated, and the nitro introduction position is precisely controlled to obtain 2-nitroaniline. Afterwards, it is reacted with a compound containing a thiophene structure with a suitable active group, such as a halogen atom, a sulfonate group, etc. Under basic conditions or in the presence of a suitable catalyst, the amino group of the aniline is connected to the thiophene by a nucleophilic substitution reaction. At the same time, at another position on the thiophene ring, a cyanyl group is introduced by cyanation reaction, such as the reaction of halogenated thiophene with reagents such as cuprous cyanide. Finally, if the methyl group on the thiophene ring is not initially present, the methyl group can be introduced under suitable conditions by methylation reaction, such as the use of iodomethane and a strong base, and the reaction is carried out in a suitable solvent to obtain 2 - (2 '-nitroanilino) -3 - cyano - 5 - methylthiophene.
The above methods require fine regulation of the reaction conditions, including temperature, solvent, reactant ratio, etc., in practice, and separation and purification are often required after each step of the reaction to ensure the purity and yield of the final product.

2-%282%27-NITROANILINE%29-3-CYANO-5-METHYL+THIOPHENE, its Chinese name may be 2- (2 '-nitroanilinyl) -3 -cyano-5 -methylthiophene. The physical properties of this substance, allow me to come to you.
Looking at its shape, under room temperature and pressure, it is mostly in a solid state. Due to the relatively strong intermolecular force, the molecular arrangement is relatively orderly. Its color is often light yellow to light brown. The formation of this color is related to the chromogenic groups in the molecular structure, such as nitro and conjugated systems, which can absorb visible light of specific wavelengths and thus exhibit corresponding colors.
When it comes to the melting point, it is within a certain range. This value depends on the magnitude of the intermolecular forces, the regularity of the crystal structure, etc. There are hydrogen bonds, van der Waals forces, and other interactions between molecules, which maintain the crystal structure and require a certain amount of heat to break, so that the substance changes from a solid state to a liquid state.
In terms of solubility, in organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. Because these organic solvents and the molecules of the substance can form similar intermolecular forces, such as Van der Waals forces, dipole-dipole interactions, etc., in line with the principle of "similar compatibility". However, the solubility in water is extremely low. Water is a highly polar solvent, which does not match the intermolecular forces of the substance, making it difficult to disperse and dissolve it.
In addition, the density of this substance is different from that of water. According to its molecular composition and structure, the density may be greater than that of water, causing it to sink in water. And the stability of this substance is acceptable under general conditions, but when exposed to specific conditions such as high temperature and strong oxidizing agent, chemical reactions may occur, and the structure and properties will change accordingly.

2-% (2 '-NITROANILINE) -3-CYANO-5-METHYL THIOPHENE is an organic compound with unique chemical properties. It contains functional groups such as nitro, amino, cyano and methyl, and each functional group endows the compound with various activities.
Nitro has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, and can be reduced to amino groups under certain conditions to derive polyamino-containing compounds. Amino groups are the power supply groups, which can increase the electron cloud density of the benzene ring, improve the activity of the electrophilic substitution reaction of the benzene ring, and can also participate in many reactions, such as reacting with acids to form salts, reacting with acyl halides or acid anhydrides to form amides, etc. Cyanyl group contains carbon and nitrogen triple bonds and has high reactivity. It can be hydrolyzed to form carboxyl groups or reacted with nucleophiles to introduce new functional groups. Methyl group is a power supply group, which has an impact on the electron cloud distribution of thiophene ring, altering the reactivity and selectivity of thiophene ring.
This compound may have certain stability and specific spectral properties due to the existence of an intramolecular conjugate system. It may have characteristic absorption peaks in the ultraviolet-visible spectrum and can be used for qualitative and quantitative analysis. It has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to synthesize compounds with more complex structures, laying the foundation for the research and development of new functional materials and drugs in the fields of medicinal chemistry and materials science. Because it contains a variety of active functional groups, it can participate in a variety of chemical reactions to construct different structural and functional compounds, meeting the needs of different fields.

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