1-benzothiophene-3-carboxylic acid

Borax is a common mineral medicine, and its main uses are quite extensive.
First, in the medical field, borax has the effect of clearing away heat and detoxifying. In case of sore throat and sores on the tongue, borax is often used as medicine. The "Compendium of Materia Medica" says: "Borax is sweet, slightly salty, cold in nature, and non-toxic." Its coolness can relieve the heat toxicity of burnt to relieve discomfort in the throat and mouth. It can be made into a powder and applied directly to the affected area, which can make the medicinal power reach the sick place and relieve the pain of swelling.
Second, in industry, borax is also widely used. In glass manufacturing, the addition of borax can improve the thermal stability and transparency of the glass. Borax can reduce the melting point of glass, making it easier for glass raw materials to melt, and can improve the properties of glass, making it more resistant to high temperature and chemical attack. In the ceramic industry, borax can be used as a flux to reduce the firing temperature of ceramic bodies, save energy, and improve the gloss and strength of ceramics, making ceramic products more beautiful and durable.
Third, in daily life, borax is also used. In the past, in some food processing, borax was occasionally used to increase the toughness, brittleness or shelf life of food. However, today, due to the potential harm to human health, borax has been strictly prohibited from being added to food.
Although borax has a variety of uses, it should be used with caution, especially when it comes to medical and daily contact, and relevant norms and safety standards must be strictly followed to prevent damage to the human body.

Borax is an important compound of boron and is also a common borate. Its physical properties are quite unique, so let me tell you one by one.
Borax usually appears as a colorless translucent crystal or a white crystalline powder. Its crystal structure is orderly and regular, so its appearance is crystal clear and quite beautiful. Borax is relatively soft in texture, with a Mohs hardness of about 2-2.5. With a light scratch of the fingernail, traces can be left on its surface.
The solubility of borax in water is worthy of attention. At room temperature, borax can be dissolved in water, and its solubility increases significantly when the temperature increases. This property makes borax play an important role in many solution-related application scenarios. For example, in some chemical processes, borax can be purified and separated by the influence of temperature on its solubility.
Borax is hygroscopic. In the air, borax will slowly absorb water, which requires special attention when storing borax. If the storage environment humidity is high, borax is prone to agglomeration due to moisture absorption, which affects its subsequent use effect.
In addition, the density of borax is about 1.73 g/cm ³. This density value allows it to exhibit corresponding physical behavior when mixed with other substances or performing specific process operations. For example, in some chemical production that requires precise control of the proportion and density of substances, the density characteristics of borax are crucial. < Br >
The melting point of borax is about 741 ° C, and the boiling point is 1575 ° C. Such a high melting point indicates that borax has good thermal stability. In high temperature environments, borax can maintain its own structure and properties relatively stable, which makes it widely used in high temperature processes such as metallurgy and glass manufacturing.

The chemical properties of borimidazole-3-carboxylic acids are unique and interesting. In the structure of borimidazole, boron atoms have electron-deficient properties, which makes this compound exhibit a different electronic effect. When it bonds with neighboring atoms, it can accept electron pairs, which affects the charge distribution and reactivity of the molecule.
As for the 3-carboxylic acid part, the carboxyl group (-COOH) is an acidic functional group. In a suitable acid-base environment, the carboxyl group can be dissociated, releasing protons (H 🥰), showing acidic properties. This acidity allows the borimidazole-3-carboxylic acid to neutralize with the base to form the corresponding carboxylate.
From the perspective of nucleophilic substitution reactions, the presence of carboxyl groups makes carbonyl carbons in molecules electrophilic and vulnerable to nucleophilic reagents. For example, under acid-catalyzed conditions, esterification reactions with alcohols can occur to form ester compounds.
The nitrogen atom of the boroimidazole part can act as a nucleophilic reagent due to its lone pair of electrons, participating in nucleophilic addition or nucleophilic substitution reactions. It can also coordinate with metal ions to form complexes, which in turn change the physical and chemical properties of compounds.
In redox reactions, boroimidazole-3-carboxylic acids exhibit specific redox behaviors due to the variable valence states of some atoms in the structure. Or it can be oxidized to a higher valence product, or under the action of a suitable reducing agent, a reduction reaction occurs, which changes the molecular structure and properties.
In addition, due to the hydrogen bonding of carboxyl groups, hydrogen bonding networks can be formed between molecules, which affects their crystal structure and aggregation properties, and contributes to the stability and physical properties of compounds in solid or solution. The chemical properties of this boronimidazole-3-carboxylic acid are diverse, and it has potential applications in many fields such as organic synthesis and materials science.

To prepare 1-benzyl-3-carboxylimidazole, there are many methods of synthesis, which will be described in detail below.
First, imidazole is used as the starting material, and benzyl is first introduced through alkylation reaction. Take an appropriate amount of imidazole, add benzyl halide, such as benzyl chloride or benzyl bromide, and then add an acid binding agent, such as potassium carbonate, and stir the reaction at an appropriate temperature. During this process, the imidazole nitrogen atom nucleophilic attacks the carbon atom of the benzyl halide, and the halogen ion leaves to generate 1-benzyl imidazole. Then, 1-benzyl imidazole is carboxylated. Carbon dioxide can be used as a carboxyl source. Under the action of a strong base such as n-butyl lithium, 1-benzyl imidazole can be lithiated first, and then carbon dioxide can be introduced to obtain 1-benzyl-3-carboxyimidazole.
Second, 1-benzyl-3-halomidazole can also be used as a raw material. First, 1-benzyl-3-halomidazole is prepared, and then it is reacted with metal magnesium to form Grignard reagent. 1-benzyl-3-halomidazole is dissolved in anhydrous ethyl ether or tetrahydrofuran, magnesium chips are added, and the reaction is initiated to obtain Grignard reagent. The target product, 1-benzyl-3-carboxyimidazole, can be obtained by reacting the Grignard reagent with carbon dioxide, followed by acid treatment.
Third, a cyclization synthesis strategy is adopted. With suitable nitrogen-containing and carbon-containing raw materials, an imidazole ring is constructed through intramolecular cyclization reaction and benzyl and carboxyl groups are introduced at the same time. For example, an amine and carbonyl compound containing benzyl and carboxyl-related structures is selected. Under the catalysis of acid or base, a series of reactions such as condensation and cyclization are used to generate 1-benzyl-3-carboxyimidazole. This method requires careful design of the raw material structure to ensure the smooth progress of the reaction. < Br >
Synthesis of 1-benzyl-3-carboxylimidazole methods are diverse, each method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, reaction conditions and purity requirements of target products, and choose the optimal synthesis path.

In today's market, the price of borax often varies from time to place, and it is difficult to determine its exact number. However, looking at the market conditions of the past years, and participating in the feelings of market trade, we can get its approximate range.
Borax is a thing with a wide range of uses, and it is useful in engineering, technology and medicine. It is also subject to supply and demand based on its price. In the past, its price changed with the rise and fall of the market and the abundance of goods.
Generally speaking, the price of ordinary borax in the market is between a catty, or between tens of dollars and hundreds of dollars. If the years are smooth, the products are abundant, and the goods are in the market, the price may trend down, only a catty or tens of dollars. At this time, the supply of goods is sufficient, and merchants compete for sales, so they have to reduce their prices to attract customers.
On the contrary, if the weather is not good, the harvest in the place of origin is not good, or the demand from the users is too high, the price will rise. The price of one catty, or to two or three hundred dollars, or even higher. If the cover is thin, it will be expensive, and people's feelings will always be.
However, this is only an approximate number. In fact, it is traded between cities, and there are differences in quality and geographical differences. The top-grade borax is pure and non-miscellaneous, and the effect is quite good. Its price must be higher than that of regular products; while in remote places, transportation is difficult, and its price is also higher than that of Dayi. < Br >
Therefore, if you want to know the exact price of borax, you can only get it when you are at the right time and place, and carefully observe the market conditions. It is not limited to one end, but the price should be judged according to all conditions.