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What is the chemical structure of -6-amino-2-propionamido-4, 5, 6, 7-tetrahydrobenzothiazole?
The chemical structure of (2S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole is an important research object in the field of organic chemistry. The structure of this compound is derived from the benzothiazole parent nucleus.
Looking at its structure, the benzothiazole parent nucleus is the core part, which is formed by fusing the benzene ring and the thiazole ring. At the 6 position of the parent nucleus, there is an amino group connected, and the amino group is nucleophilic. In many chemical reactions, it can participate in nucleophilic substitution, condensation and other reactions, which have far-reaching effects on the chemical properties and biological activities of the compound. < Br >
And the 2-position is connected with a propionamide group. The existence of this amide group increases the polarity and steric resistance of the molecule, which has a significant effect on the solubility, stability and interaction with biological targets of the compound. In addition, the conjugation effect between the carbonyl group and the nitrogen atom in the propionamide group also affects the electron cloud distribution of the whole molecule.
Furthermore, the tetrahydro structure of the 4,5,6,7 position saturates part of the double bond of the benzothiazole parent nucleus, changes the planarity and rigidity of the molecule, and then affects its physical and chemical properties, such as melting point, boiling point, etc. At the same time, it is also of great significance for the conformational adaptation of its interaction with biological macromolecules. This unique chemical structure endows (2S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole with specific chemical and biological activities, and has potential application value in drug development, organic synthesis and other fields.
(S) What are the physical properties of -6-amino-2-propionamido-4, 5, 6, 7-tetrahydrobenzothiazole?
(S) -6-amino-2-propionylamino-4, 5, 6, 7-tetrahydrobenzothiazole is an organic compound. Its physical properties are crucial and related to the application of this compound in various fields.
Looking at its morphology, under normal temperature and pressure, (S) -6-amino-2-propionylamino-4, 5, 6, 7-tetrahydrobenzothiazole is mostly solid, with fine texture or crystalline form. This morphological characteristic makes it relatively stable during storage and transportation, and is not easily changed significantly due to slight vibration or temperature changes.
When it comes to melting point, this compound has a specific melting point value, but the exact value depends on the experimental determination. The melting point is the critical temperature at which a substance changes from solid to liquid. For (S) -6-amino-2-propionylamino-4,5,6,7-tetrahydrobenzothiazole, the melting point reflects the strength of its intermolecular forces. Higher melting points indicate stronger intermolecular forces and more stable structures.
Solubility is also one of the key physical properties. (S) -6-amino-2-propionylamino-4,5,6,7-tetrahydrobenzothiazole has different solubility in different solvents. In polar solvents, such as water and alcohols, there may be a certain solubility. Because the molecular structure contains polar groups, intermolecular forces, such as hydrogen bonds, can be formed with polar solvents to promote dissolution. In non-polar solvents, such as alkanes, the solubility may be very small, because the molecular polarity is different from that of non-polar solvents, and the interaction force is weak.
In addition, the density of this compound is also an important physical parameter. Density reflects the mass of a unit volume of matter, and its value is closely related to the molecular structure. Appropriate density can affect its distribution and behavior in mixed systems. In practical applications, such as in pharmaceutical preparations, chemical synthesis, etc., the consideration of density helps to determine its dosage and mixing ratio. The physical properties of (S) -6-amino-2-propionylamino-4,5,6,7-tetrahydrobenzothiazole, such as morphology, melting point, solubility, density, etc., play an important role in its identification, separation, purification and application in various fields.
(S) What are the synthesis methods of -6-amino-2-propionamido-4, 5, 6, 7-tetrahydrobenzothiazole?
The synthesis method of (S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole is an important topic in the field of organic synthesis. Its synthesis method has been studied by many predecessors, and the advantages and disadvantages of each method are mutually different.
One method is to use a specific sulfur-containing compound and a nitrogen-containing reagent as the starting material, and through condensation reaction, the benzothiazole skeleton is formed first. This step requires selecting suitable reaction conditions, such as temperature, solvent and catalyst. If the temperature is too high, or side reactions occur, the yield will decrease; if the temperature is too low, the reaction will be slow and take a long time. The nature of the solvent also affects the reaction process. Polar solvents may favor ionic reactions, but non-polar solvents may be suitable for certain nucleophilic substitutions. The choice of catalyst depends on the reaction rate and selectivity, or use acidic catalysts or basic catalysts, depending on the specific reaction mechanism.
Then, the skeleton is modified to introduce amino and propionamide groups. When introducing amino groups, reactions such as nucleophilic substitutions can be used, but attention should be paid to the positioning and selectivity of amino groups. When introducing propionamide groups, the reaction path and reagents should also be carefully selected, or acylation should be achieved. In this process, protection and deprotection strategies are often indispensable to prevent unnecessary reactions from occurring at other activity check points.
There is another method, which is to gradually build the target molecule from different starting materials and through multi-step reactions. The key intermediates are synthesized first, and then the parts are spliced together. This strategy requires precise design of the reaction steps to ensure the yield and purity of each step of the reaction. The connection between each step of the reaction also needs to be carefully considered, or it involves functional group conversion, activation and other operations.
Another biosynthetic method has been tried, using enzymatic reactions in vivo, which has the advantages of green, high efficiency and good selectivity. However, biosynthesis also faces many challenges, such as the acquisition of enzymes and the optimization of the reaction system. The activity of enzymes is easily affected by external factors, such as pH, temperature, etc., so the reaction conditions need to be strictly controlled to ensure the smooth progress of synthesis.
All these synthesis methods need to be explored in detail by chemists, weighing the pros and cons, and choosing the optimal method according to actual needs and conditions. Synthesis of (S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole.
(S) In what areas are -6-amino-2-propionamido-4, 5, 6, 7-tetrahydrobenzothiazole applied?
(S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole is used in many fields such as medicine and chemical industry.
In the field of medicine, it is often a key intermediate for the synthesis of many drugs. Due to its unique chemical structure, it can interact with specific targets in organisms to help develop new antibacterial and antiviral drugs. For example, by modifying its structure, high-efficiency and low-toxicity antibacterial agents against specific bacteria can be created, providing a new way for clinical treatment of infectious diseases. Furthermore, in the research and development of anti-tumor drugs, it may also play a role in inhibiting the growth and proliferation of tumor cells by precisely acting on tumor cell-related targets.
In the chemical industry, it can be applied to the synthesis of fine chemicals. For example, in the synthesis of some high-end dyes and fragrances, (S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole can be introduced as a special structural unit, giving the product unique properties. In the field of dyes, it can improve the color and fastness of dyes; in the field of fragrances, it can add the unique aroma and stability of fragrances.
In addition, in the field of materials science, with the deepening of research, it may emerge in the preparation of new functional materials. It can be used to combine with other materials to endow materials with special optical, electrical or mechanical properties, injecting new vitality into the innovation and development of materials.
(S) What is the market outlook for -6-amino-2-propionamido-4, 5, 6, 7-tetrahydrobenzothiazole?
(S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole is a unique organic compound. In today's market situation, its prospects can be described as complex and diverse.
Looking at the field of medicine, due to its special structure or potential biological activity, it can be used as a key intermediate for drug development. With the deepening of disease treatment research, the demand for new drugs is increasing. If this substance can demonstrate unique efficacy in pharmacological research, such as high affinity and selectivity for specific disease targets, its market demand may increase significantly.
In the chemical industry, it can be used as a raw material for fine chemicals for the synthesis of high-end materials or special additives. As the chemical industry moves towards high-end and refined, the demand for such special compounds is expected to rise. However, its market development is also constrained by many factors. The complexity of the synthesis process determines the level of production costs. If the process is complicated and the cost remains high, its large-scale application will be restricted.
Furthermore, the impact of regulations and policies cannot be underestimated. Environmental regulations are increasingly stringent. If the production process does not meet the requirements, enterprises may face the risk of rectification or even shutdown. And the market competition situation also affects its development. The emergence of similar alternative products may intensify the competition. However, generally speaking, if we can break through the bottleneck of synthesis technology, reduce costs, and comply with regulatory requirements, (S) -6-amino-2-propionamido-4,5,6,7-tetrahydrobenzothiazole may have considerable development space in the future market, and is expected to emerge in the fields of medicine, chemical industry, and contribute to the development of related industries.