What is the chemical structure of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1)

This is N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1), and its chemical structure is depicted as follows:

The benzothiazole ring is the core, and this ring is formed by fusing the benzene ring with the thiazole ring. At the 1,3-position, there are sulfur atoms and nitrogen atoms, respectively, to construct the basic structure of the thiazole ring. 4,5,6,7-tetrahydro indicates that the 4,5,6,7 positions of the benzene ring part are all saturated carbon atoms, and the double bonds of the benzene ring in this structure are hydrogenated.

At the 2-position, there is an amino group (-NH -2), and at the 6-position, there is an amino group (-NH -2). N6-propyl means that the nitrogen atom of the 6-position amino group is connected to a propyl group (-CH -2 CH -2 CH 😉).

The compound is hydrochloride (1:1), that is, an N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine molecule and a hydrogen chloride molecule are bound by ionic bonds, in which the lone pair electrons on the nitrogen atom form a coordination bond with the hydrogen ion, and the chloride ion is attracted to the positively charged organic cation to form a stable ionic compound. In this way, the chemical structure of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1) is clearly presented.

What are the main uses of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1)

N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1) has a wide range of uses. In the field of medicine, it is often the key raw material for the development of new drugs. Due to its special chemical structure, it can specifically bind to biological macromolecules in the body, or can regulate specific physiological processes, and has potential efficacy in the treatment of certain diseases, such as neurological disorders, cardiovascular diseases and other related drug development, or can play an important role.

In scientific research experiments, this compound is also an important research tool. Chemists can explore the synthesis path of new compounds by performing various chemical reactions and modifications to expand the boundaries of organic synthetic chemistry. And it can be used to study the interaction between molecules, helping researchers to gain a deeper understanding of the mechanism of chemical processes in living organisms.

Industrial production level, it may be applied to the field of materials science. For example, as a functional additive, it endows materials with unique chemical or physical properties, such as improving the stability of materials and enhancing their compatibility with other substances, which may have application opportunities in polymer materials, coatings and other industries.

What are the physical properties of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1)

N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1), this is an organic compound. Its physical properties are quite characteristic, let me tell them one by one.

Looking at its properties, it is a crystalline powder under normal circumstances, fine and uniform, with a certain luster. Its color is often white to off-white, pure and free of variegation, which is due to its regular molecular structure and good crystal form.

When it comes to solubility, the compound behaves differently in common organic solvents. In water, due to its amino group and hydrochloride content, hydrogen bonds and ion-dipole interactions can be formed, so it has a certain solubility and can partially dissolve to form a clear or slightly cloudy solution. In alcohol solvents such as methanol and ethanol, the solubility is also acceptable, and hydrogen bonds can be formed between alcohol hydroxyl groups and compound molecules to promote their dissolution. However, in non-polar organic solvents such as n-hexane and benzene, because their molecules have a certain polarity, the force between them and the non-polar solvent is weak, so the solubility is extremely low and almost insoluble.

Melting point is also one of the important physical properties. After determination, its melting point is in a specific temperature range, which reflects the strength of the intermolecular force. When heated to the melting point, the molecule obtains enough energy, and the lattice structure begins to disintegrate, transforming from a solid state to a liquid state. The precise melting point value is of great significance for the identification and purity judgment of the compound. The higher the purity, the closer the melting point is to the theoretical value and the narrower the melting range.

In addition, the density of the compound is also a specific value, which is related to the molecular weight and the way of molecular packing. Density measurement can assist in determining its proportion in the mixture, providing an important reference for operations such as separation and purification.

The physical properties of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1) lay the foundation for its research and application in the fields of chemistry and medicine. Researchers can follow up on this characteristic.

What is the synthesis method of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1)

To prepare N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1), you can follow the following ancient method.

First take an appropriate amount of 4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine and place it in a clean reactor. The kettle should be slowly heated on a charcoal fire so that no moisture remains in it.

Take another propylation reagent, such as propyl halide, and slowly inject it into the kettle according to the appropriate molar ratio. At the same time, add an appropriate amount of alkali, such as potassium carbonate or sodium carbonate, to help the reaction proceed. The alkali needs to be ground to a very fine powder before it can be put into use.

Here, heat the reaction system with a slow fire to maintain the temperature in a moderate range, about 60 to 80 degrees Celsius. During this time, continuously stir with a wooden paddle to allow the reactants to be fully mixed and the reaction is uniform. After several hours, observe the reaction progress by thin layer chromatography or other suitable monitoring means until the raw materials are almost exhausted.

After the reaction is completed, cool the reaction solution to room temperature. Then, slowly drop in an appropriate amount of dilute hydrochloric acid, adjust its pH to acidic, and precipitate the product in the form of hydrochloric acid salts. When adding dropwise, be careful not to overdo the acid. < Br >
Then pour the mixture into the separation funnel, extract several times with an organic solvent such as ethyl acetate or dichloromethane, and separate the organic phase. The organic phase is dried with anhydrous sodium sulfate and allowed to stand for a while to remove water.

After that, the organic solvent is removed by a rotary evaporator to obtain a crude product. The crude product is purified by recrystallization, and a suitable solvent is selected, such as a mixed solvent of ethanol and water. After heating and dissolving, it is slowly cooled to allow crystals to precipitate. Finally, the crystals were washed by suction filtration with a small amount of cold solvent, and after drying, the pure product of N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1) was obtained.

N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1) What are the precautions during use

This is N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrochloride (1:1). When using, there are many precautions that need to be taken with caution.

Bearing the brunt, safety is as important as Mount Tai. This compound may be potentially toxic and irritating. When exposed, be fully armed, wear protective clothing, protective gloves, and eye protection goggles to prevent it from coming into contact with the skin and eyes and causing damage. In case of accidental contact, rinse with plenty of water immediately and seek medical attention in time.

Furthermore, the chemical properties cannot be ignored. Because it is a hydrochloride salt, it may absorb moisture in humid air, which in turn affects its stability and purity. Therefore, it needs to be properly stored in a dry, cool and well-ventilated place, away from fire sources and oxidants, to prevent dangerous chemical reactions.

During use, accurate operation is essential. When weighing and measuring, it is necessary to use accurate equipment, strictly follow the experimental requirements or production standards, and control the dosage. It must not be increased or decreased at will, so as not to affect the experimental results or product quality.

In addition, when the compound participates in the reaction, the reaction conditions need to be strictly controlled. Factors such as temperature, pH, and reaction time all have a profound impact on the reaction process and product formation. It needs to be carefully adjusted according to the established reaction mechanism and experience to ensure the smooth progress of the reaction.

Finally, after use, the remaining materials and waste cannot be discarded at will. Relevant regulations should be followed and properly disposed of to prevent pollution to the environment.