METHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE

Methyl-2-aminothiazole-4-carboxylate, this is an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. The unique structure of the guienthiazole ring has good biological activity and drug affinity. By modifying its structure, new drugs with various pharmacological activities such as antibacterial, anti-inflammatory and anti-tumor can be created.
In the field of pesticide chemistry, it also plays an important role. It can be used to synthesize specific insecticides and fungicides. Thiazole compounds exhibit high-efficiency inhibition and killing effects on certain pests and pathogens, which can help improve crop yield and quality and ensure agricultural production.
Furthermore, in the field of materials science, methyl-2-aminothiazole-4-carboxylic acid esters may participate in the synthesis of special functional materials. Due to their structural properties, or endowing materials with unique properties such as optics and electricity, they open up new paths for the research and development of new materials. In short, methyl-2-aminothiazole-4-carboxylic acid esters have important application value in many fields and are of great significance to promote the development of related industries.

METHYL 2 - AMINOTHIAZOLE - 4 - CARBOXYLATE, that is, methyl 2-amino-4-thiazolecarboxylate, is a kind of organic compound. This substance has specific physical properties and is detailed as follows:
- ** Properties **: Under room temperature and pressure, it is mostly in the state of white to light yellow crystalline powder. It is delicate and uniform in appearance, and its purity can be seen as quite high. This form is convenient for storage, transportation and subsequent experimental operation.
- ** Melting point **: Its melting point is about 155-158 ° C. Melting point is one of the important physical constants of a substance. This value indicates that the compound gradually melts from a solid state to a liquid state in this temperature range, and its purity and characteristics can be identified accordingly. If the sample purity is extremely high, the melting point range is very narrow; conversely, if it contains impurities, the melting point may decrease and the range becomes wider.
- ** Boiling point **: In a specific pressure environment, the boiling point is about 320.4 ° C. The boiling point reflects the temperature conditions required for a substance to change from a liquid state to a gaseous state, which is of great significance for its separation, purification and reaction conditions. < Br > - ** Solubility **: Methyl 2-amino-4-thiazolecarboxylate is slightly soluble in water, but exhibits good solubility in organic solvents such as ethanol, dichloromethane, N, N-dimethylformamide (DMF). This solubility property is closely related to the molecular structure. The polar and non-polar parts of the molecule interact together, resulting in different solubility behaviors in different solvents. This property can be used in organic synthesis to select suitable solvents to promote the reaction or separate the product.
- ** Density **: about 1.372g/cm ³. Density reflects the mass per unit volume of a substance, and is indispensable when it comes to accurate measurement and reaction system configuration. It can help experimenters accurately control the amount of reactants and the reaction process. The physical properties above
are of great significance in organic synthesis, medicinal chemistry and other fields. In organic synthesis, the appropriate separation and purification method can be selected according to the melting point and boiling point; solubility affects the choice of reaction solvent, which in turn affects the reaction rate and yield; density is an important reference index in precise experimental operation.

The chemical synthesis of methyl-2-aminothiazole-4-carboxylic acid esters has been known in ancient times and is described in detail below.
In the past, thiourea and ethyl bromopyruvate were often used as starting materials. The two interact under suitable reaction environments, such as specific temperatures, pressures and catalysts. The nitrogen atom of thiourea nucleophilically attacks the carbonyl carbon of ethyl bromopyruvate, triggering a series of intramolecular rearrangements and cyclization reactions. After this step, the prototype of the thiazole ring is initially formed.
Then, appropriate modifications are applied to the formed intermediate. Either hydrolysis or esterification reactions to introduce the desired methyl and amino groups. In the hydrolysis reaction, it is necessary to precisely control the pH, temperature and time of the reaction to properly convert the ester group and ensure the stability of the thiazole ring. In the esterification reaction, the opposite is true. Under appropriate conditions, the carboxyl group is combined with alcohols such as methanol to form the carboxylic acid ester part of the target product.
There is also another method. Ethyl acetoacetate is used as the starting material and condensed with thiourea to obtain the key intermediate first. This intermediate is then halogenated, cyclized and other steps to gradually construct the thiazole ring structure. During the halogenation process, the introduction position and quantity of halogen atoms need to be strictly controlled, so it is related to the structure and purity of the final product. The cyclization step also requires careful operation, selecting suitable bases and reaction solvents, so that the molecules can be cycled smoothly to obtain compounds containing thiazole rings. Subsequently, after further modification, the introduction of methyl and amino groups is completed, and the final methyl-2-aminothiazole-4-carboxylate is obtained.
This number method has its own advantages and disadvantages. The choice of raw materials is related to cost and availability; the complexity of the reaction steps affects the production efficiency; the severity of the reaction conditions also affects the yield and purity of the product. All factors need to be considered comprehensively to obtain the best synthesis path.

It is difficult to determine the price range of methyl-2-aminothiazole-4-carboxylic acid ester in the market. The price of methyl-2-aminothiazole-4-carboxylic acid ester often changes for many reasons, just as "Tiangong Kaiwu" said, all things are affected by the situation of time and place.
The first to bear the brunt is the raw material for the production of this product. If the raw material is easy and abundant, the price may be slightly cheaper; if the raw material is scarce and difficult to purchase, the cost will increase, and its price in the market will also rise.
Furthermore, the complexity of the preparation process also affects the price. If the craftsmanship is simple, it saves manpower and material resources, and the price may be stable; if the craftsmanship is complicated, requires exquisite equipment and exquisite skills, and consumes a lot, the price will be high.
The state of market supply and demand is also the key. If there are many seekers and there is little supply, the so-called "what is rare is expensive", the price will tend to rise; if the supply is abundant, and there are few applicants, the price may fall.
In addition, the location and season also have an impact. In different places, due to different transportation, taxation, etc., the price varies; changes in seasons may cause differences in the output of raw materials, which also makes prices fluctuate.
According to the usual situation, the price of methyl-2-aminothiazole-4-carboxylate is between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximate figure. To know the exact price, you need to carefully observe the current market situation and consult industry experts or professionals.

Methyl-2-aminothiazole-4-carboxylic acid ester is one of the chemical substances. Its storage conditions are crucial and related to the stability and quality of the substance.
This substance should be stored in a cool and dry place. In a cool place, it can avoid the disturbance of high temperature, which can easily cause its chemical properties to change, or cause decomposition and deterioration. A dry environment is also indispensable, because moisture is often the cause of chemical reactions, which can make the substance absorb moisture, which in turn affects its purity and activity.
and should be placed in a well-ventilated place. With good ventilation, it can avoid the accumulation of harmful gases and prevent them from interacting with substances and damaging quality. At the same time, be sure to keep away from fire sources, heat sources and oxidants. Fire sources and heat sources can easily cause substances to be heated, or risk combustion or explosion; oxidants come into contact with the substances, or trigger violent chemical reactions, endangering safety.
Furthermore, the choice of storage containers should not be underestimated. Use containers with good sealing performance to prevent substances from coming into contact with air, causing oxidation or absorbing components in the air and causing qualitative changes. Clear labels are also necessary, indicating key information such as the name of the substance, characteristics, and storage requirements for easy access and management. In this way, methyl-2-aminothiazole-4-carboxylate must be properly stored to ensure its quality and safety.