Methyl 2-amino-5-bromothiazole-4-carboxylat

Methyl-2-amino-5-bromothiazole-4-carboxylate, this is an organic compound. Looking at its structure, the thiazole ring is the core, which is above the 2-position amino group, the 5-position bromo atom, and the 4-position carboxyl group and forms a methyl ester.
In terms of its chemical properties, the amino group is basic and can form a salt with an acid. In case of hydrochloric acid, the amino nitrogen atom will bind to the proton to obtain the corresponding salt. This reaction changes the solubility or reactivity of the compound. It can be used as an intermediate in organic synthesis. After specific reactions, new compounds containing different functional groups are derived.
Bromine atom is a halogen atom with high reactivity. Nucleophilic substitution reactions can occur, such as the reaction with sodium alcohol, bromine atoms are replaced by alkoxy groups to form ether derivatives, which are commonly used in the construction of complex organic molecular structures.
Carboxyl methyl ester moiety, ester groups can be hydrolyzed, under acidic or alkaline conditions, carboxylic acids and methanol are obtained respectively. Basic hydrolysis is more thorough, because the resulting carboxylic salts are stable. This hydrolytic property allows the compound to be used to prepare specific carboxylic acid compounds.
And because of its heterocyclic structure, it may have potential biological activity in the field of pharmaceutical chemistry. Or it can interact with specific targets in organisms, such as proteins, enzymes, etc., to exhibit antibacterial, anti-inflammatory and other pharmacological properties, providing the possibility for the development of new drugs.

Methyl-2-amino-5-bromothiazole-4-carboxylate, this is an organic compound with a wide range of common uses.
In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. For example, in the development of antibacterial drugs, by chemically modifying and derivatizing the compound, new antibacterial agents that exhibit strong inhibition on specific pathogenic bacteria may be created. Because the thiazole ring structure is ubiquitous in many bioactive molecules, and the amino group, bromine atom and carboxylate group can participate in a variety of chemical reactions, so as to achieve precise regulation of compound activity and selectivity.
In the field of materials science, methyl-2-amino-5-bromothiazole-4-carboxylate can be used to prepare functional materials. For example, by assembling with other organic or inorganic compounds, materials with special optical, electrical or adsorption properties can be constructed. The different functional groups it contains can give the material unique properties, such as the presence of bromine atoms or the distribution of electron clouds in the material, which in turn affects its photoelectric properties.
In the field of agricultural chemistry, this compound may be used as a pesticide intermediate. After reasonable structural modification and optimization, pesticide products with high insecticidal, bactericidal or herbicidal activities may be developed. The components of its structure can interact with specific targets in the organism to achieve the desired agrochemical effects.

To prepare methyl 2-amino-5-bromothiazole-4-carboxylic acid ester, the following method can be used.
First select suitable starting materials, such as compounds containing bromine, amino and thiazole structures, and select them to fit the reaction mechanism and subsequent transformation. Using bromine-containing halogenates and amino-containing reagents, the reaction conditions are cleverly designed to make them condensate to construct the initial shape of the thiazole ring. Among these, the choice of reaction solvents is crucial, such as polar aprotic solvents, such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), can promote the reaction because it can dissolve the raw material and stabilize the transition state. < Br >
Then, specific positions on the thiazole ring are modified to introduce carboxyl groups and form esters. The carboxyl-containing reagents can be reacted with suitable check points on the ring through nucleophilic substitution. To obtain methyl esters, methanol can be selected with corresponding carboxyl-activating reagents, such as dichlorosulfoxide, oxalyl chloride, etc. The carboxyl groups are first converted into active acid chlorides, and then reacted with methanol to form esters.
During the reaction process, the temperature, time, and the proportion of reactants need to be precisely controlled. If the temperature is too high or the side reactions occur frequently, if it is too low, the reaction will be slow or even stagnant. Improper proportion of reactants also affects the yield and purity. < Br >
After each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to remove impurities and obtain pure products. In this way, after careful design and strict operation, methyl 2-amino-5-bromothiazole-4-carboxylate can be obtained.

The market price of methyl-2-amino-5-bromothiazole-4-carboxylate is difficult to say in a word. This compound is rarely recorded in ancient books such as Tiangong Kaiwu. Because it is a product of modern chemical synthesis, it is located in a chemical field that is far from what is involved in traditional books.
To know its market price today, you need to look at many factors. First, the difficulty of production is the key. If the preparation process is complicated, special raw materials are required, harsh reaction conditions are required, or multiple steps of fine synthesis are required, the cost will be high, and the price will also rise. Second, the situation of market supply and demand also affects the price. If this compound is in high demand in the pharmaceutical, materials and other industries, but the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may decline. Third, the production scale also has an impact. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price will be more competitive.
In today's chemical market, the price of methyl-2-amino-5-bromothiazole-4-carboxylate fluctuates. On the fine chemical raw material trading platform, the price per gram may range from tens of yuan to hundreds of yuan depending on the purity, packaging and purchase quantity. High-purity products are often expensive because they meet the needs of high-end scientific research and pharmaceutical production; while low-purity products are mostly used for general industrial purposes and are relatively affordable. However, in general, the exact price must be consulted by professional chemical raw material suppliers to obtain the most accurate quotation information.

Methyl-2-amino-5-bromothiazole-4-carboxylate This product requires attention to many matters during storage and transportation.
When storing, the temperature and humidity of the environment should be the first priority. The product should be stored in a cool and dry place. Due to high temperature and humidity, or its properties may change, and even cause chemical reactions, resulting in damage to its quality. If placed in a hot flush place, it may deliquescence, affecting its chemical stability and purity.
Furthermore, it is quite sensitive to light. It should be stored in a container protected from light. Light may cause photochemical reactions to occur, causing decomposition of active ingredients and reducing its efficacy. Therefore, it is advisable to use a brown bottle or a container with a light-shielding coating.
When transporting, the packaging must be stable and tight. The material may have certain chemical activity, vibrate, collide on the way, or cause damage to the packaging, causing leakage. Leakage not only causes material loss, but also causes dangerous reactions if it comes into contact with other substances. Therefore, the packaging material must have good seismic and compressive resistance.
In addition, the transportation environment should also be paid attention to. It should not be transported with oxidizing and reducing substances, because of its chemical properties, or react violently with such substances, endangering transportation safety. And the transportation tool should be kept clean and dry without other chemical residues to avoid contamination of methyl-2-amino-5-bromothiazole-4-carboxylate.
In short, when storing and transporting methyl-2-amino-5-bromothiazole-4-carboxylate, environmental temperature and humidity, light, packaging stability and transportation compatibility must be treated with caution to ensure its quality and transportation safety.