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What is the chemical structure of methyl 2 - amino - 5 - bromo - 1, 3 - thiazole - 4 - carboxylate?
The Chinese name of this compound is "2-amino-5-bromo-1,3-thiazole-4-carboxylic acid methyl ester". Its chemical structure is as follows:
-thiazole ring is the core skeleton of this compound, 1,3-thiazole is a five-membered heterocyclic ring containing one sulfur atom and one nitrogen atom. The sulfur atom is at position 1 and the nitrogen atom is at position 3.
- At position 2 of the thiazole ring is connected to the amino group (-NH2O), and at position 5 is connected to the bromine atom (-Br).
-thiazole ring at position 4 is connected to the carboxylic acid methyl ester group (-COOCH 🥰), which is formed by the esterification reaction of carboxyl group (-COOH) with methanol (CH 🥰 OH), that is, the hydroxyl group in the carboxylic group is replaced by methoxy group (-OCH 🥰).
In summary, the chemical structure of "2-amino-5-bromo-1,3-thiazole-4-carboxylic acid methyl ester" is composed of a thiazole ring as the core, which is connected to an amino group, a bromine atom and a carboxylic acid methyl ester group at a specific position.
What are the main uses of methyl 2 - amino - 5 - bromo - 1, 3 - thiazole - 4 - carboxylate?
Methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylic acid ester, which has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of specific drugs. The creation of many antibacterial and antiviral drugs depends on their participation in the reaction. After ingenious chemical modification and transformation, molecules with specific biological activities are obtained to accurately respond to the invasion of bacteria and protect human health.
In the field of pesticides, it also plays an important role. It can be used as a precursor to synthetic high-efficiency pesticides. Such pesticides are highly targeted and lethal to pests, but they are friendly to the environment. They can effectively prevent and control pests and diseases, ensure a good harvest of crops, and less disturb the ecological balance.
In the field of materials science, it has also made its mark. It may be able to participate in the construction of functional materials through special processing, endowing materials with unique optical and electrical properties. It has potential application value in cutting-edge technology fields such as optoelectronic devices and sensors, and provides new opportunities and possibilities for the innovation and development of related industries.
What are the synthesis methods of methyl 2 - amino - 5 - bromo - 1, 3 - thiazole - 4 - carboxylate?
The synthesis method of methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylic acid ester, although the synthesis of this compound is not described in the ancient book "Tiangong Kaiwu", it can be explored according to the ancient chemical concepts and ideas.
To prepare this compound, it may be started with sulfur, nitrogen and halogenated compounds. If an appropriate sulfur source is taken first, it will react with nitrogen-containing halogenated hydrocarbons with sodium hydrosulfide or thiourea. Let thiourea react with halogenated alkenes such as 2-bromo-3-chloropropene, in a suitable solvent, such as ethanol or dichloromethane, and heat to reflux, so that the sulfur atom of thiourea is nucleophilic and attacks the halogenated atom of halogenated alkenes to form a sulfur-nitrogen heterocyclic precursor.
Subsequently, the precursor is carboxylated. Carbon dioxide gas can be selected, and in an autoclave, in the presence of a suitable base, such as potassium carbonate or sodium carbonate, the precursor is reacted with carbon dioxide, and at a specific temperature and pressure, the carboxyl group is connected to the heterocyclic ring.
After the carboxylation is completed, the esterification reaction is carried Methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylic acid ester can be obtained by taking an appropriate amount of methanol and the above-mentioned carboxyl-containing products under the catalysis of concentrated sulfuric acid and heating for esterification.
During the operation, it is advisable to pay attention to the control of the reaction temperature, time and material ratio, and the product should be properly separated and purified after each step of the reaction to ensure the purity and yield of the final product. Although this idea is not directly based on "Tiangong Kaiqi", it is possible to achieve the purpose of synthesis by following the spirit of inquiry of the ancients on material transformation.
What are the physical properties of methyl 2 - amino - 5 - bromo - 1, 3 - thiazole - 4 - carboxylate?
Methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylic acid ester, which is an organic compound. Looking at its structure, it contains a thiazole ring, and there are amino groups, bromine atoms and ester groups on the ring.
In terms of physical properties, at room temperature, it may be a solid due to its intermolecular forces and structure. In terms of melting point, it is affected by intermolecular forces, hydrogen bonds and crystal structure, or due to strong intermolecular interactions, and the melting point is relatively high. However, the exact value still needs to be determined accurately by experiments.
In terms of solubility, it is an organic ester. According to the principle of similar miscibility, it may have good solubility in organic solvents such as ethanol and dichloromethane. Due to the structural similarity of organic solvents and this compound, the intermolecular forces can cause the two to mix with each other. In water, the solubility may be poor, because the ester group and thiazole ring are non-hydrophilic groups, and the forces between water molecules are weak.
Appearance may be white to light yellow powder, due to the absorption and reflection characteristics of molecular structure. These physical properties of this compound are of great significance for its application in the fields of organic synthesis and medicinal chemistry. In organic synthesis, solubility affects the choice of reaction medium; melting point is related to reaction temperature control. In medicinal chemistry, physical properties are closely related to the absorption, distribution, metabolism, and excretion of drugs. Therefore, in-depth understanding of their physical properties is crucial for further research and application of this compound.
What is the market outlook for methyl 2 - amino - 5 - bromo - 1,3 - thiazole - 4 - carboxylate?
Methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylic acid ester, which has a promising market situation, is a key intermediate in the field of organic synthesis that has attracted much attention. Looking back at the past, with the rapid development of the pharmaceutical, pesticide and material science industries, its demand has also been steadily rising.
In the field of medicine, many new drugs are created based on it as a basic raw material. The genthiazole ring structure has unique biological activity and pharmacological properties in the design of drug molecules, and can be closely matched with specific biological targets, thus demonstrating excellent therapeutic efficacy. Therefore, with the continuous deepening of pharmaceutical research and development, the exploration and development of new thiazole-containing drugs are in the ascendant. Methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylate is a key synthetic block, and its market demand has risen rapidly.
In the field of pesticides, this compound has emerged in the creation of new pesticides due to its special chemical structure. It can derive pesticide products with high efficiency, low toxicity and environmentally friendly characteristics, which is in line with the current trend of green agriculture development. With the increasing global emphasis on the quality and safety of agricultural products and environmental protection, the green pesticide market has broad prospects, which in turn strongly drives the market demand for methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylate.
In the field of materials science, with the continuous expansion of functional materials research, materials containing thiazole structures are gradually applied to optoelectronic materials, polymer materials and many other aspects due to their unique optical and electrical properties. Methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylate is an important starting material for the construction of such materials, and the market potential is considerable.
However, it should be noted that the market also faces some challenges. On the one hand, the synthesis process is complex and costly, which restricts large-scale production and application promotion; on the other hand, the market competition is becoming increasingly fierce, and many manufacturers have joined it. However, in general, in view of the strong demand in the downstream industry, the market prospect of methyl-2-amino-5-bromo-1,3-thiazole-4-carboxylic acid ester is still extremely broad, and the development space is quite huge.
