ISOTHIAZOLE-5-CARBOXYLIC ACID

Isothiazole-5-carboxylic acid (ISOTHIAZOLE-5-CARBOXYLIC ACID) has a wide range of uses and has important applications in many fields.
First, in the field of medicine, this compound can be used as a key intermediate for drug synthesis. Doctors and pharmacists use isothiazole-5-carboxylic acid as the starting material through ingenious chemical reactions to carefully construct drug molecules with specific biological activities. For example, for some inflammation-related diseases, the drugs developed are synthesized from this intermediate. With its unique chemical structure, it precisely combines with inflammation-related targets in the body to exert anti-inflammatory effects and relieve the pain of patients.
Second, in the field of agriculture, it can be used to create new pesticides. Agriculture is related to the national economy and people's livelihood, and the control of pests and diseases is the key to ensuring crop yield and quality. Pesticides derived from isothiazole-5-carboxylic acid can effectively inhibit the growth, reproduction, or killing of pests by virtue of their unique mechanism of action against specific pests or pathogens. Compared with traditional pesticides, they may have more environmentally friendly and efficient characteristics, which is conducive to the sustainable development of agriculture.
Third, in the field of materials science, it has also emerged. Researchers have introduced it into the synthesis process of polymer materials, which can endow materials with special properties such as antibacterial and antiseptic properties. For example, in some plastic products or coatings that are susceptible to microbial attack, adding additives containing isothiazole-5-carboxylic acid structures can significantly extend the service life of the material, improve the quality and performance of the material, and make it useful in construction, home furnishing, and many other industries.

Isothiazole-5-carboxylic acid (ISOTHIAZOLE-5-CARBOXYLIC ACID) is one of the organic compounds. Its physical properties are particularly important and are detailed as follows.
First appearance, isothiazole-5-carboxylic acid is often white to light yellow crystalline powder. This morphological feature is of great reference value for identifying and preliminarily judging its purity. Looking at its color and shape, you can get a rough idea of its approximation.
Times and melting point, the melting point of this substance is about [specific melting point value]. The melting point is the inherent physical characteristic of the substance, just like the disposition of a human being, and it is not easy to change. With this characteristic, the authenticity of its purity can be tested. If the deviation between the melting point and the constant value is too large, the purity is worrying.
Furthermore, the solubility of isothiazole-5-carboxylic acid in water also needs to be considered. Generally speaking, its solubility in water is limited, but in some organic solvents, such as ethanol, acetone, etc., the solubility is slightly higher. This difference in solubility is of great significance in operations such as separation, purification and preparation of related solutions. Making good use of this property can make the operation twice as effective with half the effort.
And density, its density is about [specific density value]. The density is the mass per unit volume of the substance. Although it is not easy to detect in daily life, it is indispensable in precise operations such as chemical production and scientific research. Accurately knowing its density can accurately calculate the dosage and configure the solution to ensure the smooth progress of the experiment or production.
In addition, the stability of isothiazole-5-carboxylic acid also belongs to the category of physical properties. Under normal temperature and pressure, its properties are relatively stable, and it may decompose under extreme conditions such as high temperature, strong acid, and strong alkali. Therefore, when storing, it is necessary to choose a suitable environment to avoid contact with inappropriate substances to ensure its quality.

The chemical properties of isothiazole-5-carboxylic acid (ISOTHIAZOLE-5-CARBOXYLIC ACID) depend on many reasons.
Looking at its structure, the isothiazole ring has a unique heterocyclic structure, in which nitrogen and sulfur atoms coexist, giving it a unique electronic effect. Nitrogen atoms have lone pairs of electrons, and sulfur atoms also have rich electron clouds. The interaction between the two makes the ring system electron clouds different. This structure makes its chemical properties active and complex.
In terms of stability, it can be relatively stable in a dry and clean environment at room temperature and pressure. However, in case of high temperature, the vibration of the chemical bond in the ring intensifies, or the bond breaks, triggering a decomposition reaction. In case of strong oxidizing agent, due to the characteristics of the electron cloud on the ring, it is easy to be oxidized, causing structural changes and loss of stability.
Furthermore, its carboxyl group is also affected. The carboxyl group is acidic, and in a basic environment, it is easy to neutralize with the base, which changes the original molecular structure and impairs the stability. And the carboxyl group can participate in reactions such as esterification, which will also shake its original structure.
Therefore, the chemical stability of isothiazole-5-carboxylic acid is not static, but actually varies with external conditions such as temperature, pH, and the presence or absence of redox substances. Under suitable and mild conditions, stability can be maintained; however, under severe conditions, stability can be easily destroyed.

The preparation method of isothiazole-5-carboxylic acid (ISOTHIAZOLE-5-CARBOXYLIC ACID) is not detailed in the ancient book "Tiangong Kaiwu", but now it can be found in chemical classics and deduced by antiquarian methods.
First, it can be started from the corresponding halogenate. Use suitable halogenated hydrocarbons in alkali solution to heat with reagents containing sulfur and nitrogen. Halogens in halogens have high activity. When exposed to alkali, their carbon-halogen bonds are easily broken, and they are connected to active groups containing sulfur and nitrogen reagents, forming the embryonic form of isothiazole rings. This step requires temperature control. If the temperature is too high, there will be many side reactions; if it is too low, the reaction will be slow.
Second, the intermediate can be oxidized to obtain a carboxyl group. Choose a suitable oxidizing agent, such as mild peroxide or strong oxidation of potassium permanganate, etc. Taking peroxide as an example, under mild conditions, a specific group in the intermediate can be oxidized to a carboxyl group. During operation, pay attention to the addition rate. If you add it slowly, the reaction will be controllable and the product purity will be high.
Third, if you start with a double bond and a sulfur-containing and nitrogen-containing raw material, you can use cyclization to form an isothiazole ring. In the presence of a catalyst, the double bond and the sulfur-containing and nitrogen-containing groups are cyclized and rearranged to gradually construct the isothiazole structure. Later, carboxyl groups are introduced according to the previous method. < Br >
During the preparation process, attention should be paid to the purity of the raw materials. Many impurities will hinder the reaction and affect the purity of the product. After the reaction, the product should be separated and purified by suitable methods, such as recrystallization, column chromatography, etc., to obtain isothiazole-5-carboxylic acid.

The price of isothiazole-5 -carboxylic acid (ISOTHIAZOLE -5 -CARBOXYLIC ACID) in the market varies depending on time, place, quality and supply and demand. In the past, its price was often influenced by many factors.
In a place where the chemical industry is prosperous, if the production and supply of this product are abundant and the demand is not abundant, the price may tend to be flat. According to past records, the price per gram of ordinary quality may be between a few dollars and more than ten dollars. However, if in a remote area, the supply is less and the demand is more, or due to transportation difficulties and changes in taxes, the price will often rise, or it can reach tens of dollars per gram.
Furthermore, the difference in quality is also the key to the price. Isothiazole-5-carboxylic acid with high purity and rare impurities, due to the difficulty of preparation, its price must be higher than that of regular products, or more than a hundred dollars per gram. And crude products, although the price is low, may be limited in use, or only a few dollars per gram.
The market situation is fluid and changeable. The price of the past can only be used for today's reference. To know the real-time price, you should consult the chemical market, merchants and experts, or explore it on a special trading platform to get a definite number.