Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(S)-

Alas! To clarify the chemical structure of " (S) -2,3,5,6-tetrahydro-6-phenylimidazolo [2,1-b] thiazole monohydrochloride", it should be derived from its name.
"Imidazolo [2,1-b] thiazole" is a fused heterocyclic structure. The imidazole ring and the thiazole ring are fused in a specific way, and "[2,1-b]" indicates the position relationship of fused.
"2,3,5,6-tetrahydro" indicates the hydrogen atom state on the carbon at positions 2, 3, 5, and 6 in this fused ring system, that is, this number is a hydrogenated state, not a double bond form.
"6-phenyl" indicates that a phenyl group is connected to the carbon atom at position 6, and this phenyl group is composed of a benzene ring composed of six carbon atoms.
And "monohydrochloride" means that the compound forms a salt with one molecule of hydrogen chloride. The hydrogen ion of hydrochloric acid is combined with the basic part of the compound, and the common parts such as nitrogen atoms can combine hydrogen ions to form salts.
As for " (S) ", it means that the compound is chiral, which is its specific configuration label, which is determined according to the Cahn-Ingold-Prelog rule, indicating its specific spatial arrangement.
Overall, this compound has a specific thickened heterocyclic structure, with hydrogenation sites and specific substituents on the ring, and is chiral, and exists in the form of monohydrochloride. Its structure is complex and delicate, and its parts are interconnected to form this unique chemical entity.

(S) -2,3,5,6-tetrahydro-6-phenylimidazolo [2,1-b] thiazole monohydrochloride, the physical properties are as follows:
Its appearance is often white to off-white crystalline powder, which is a visually recognizable state. In terms of solubility, it has a certain solubility in water, and it can interact with water molecules to form hydrated ions and dissolve; it also has certain solubility in organic solvents such as ethanol and methanol, but it has poor solubility in non-polar solvents such as n-hexane and benzene, because the molecular polarity is different from that of non-polar solvents.
The melting point is one of the key indicators of physical properties. Its melting point is within a certain range. The specific value can be obtained by accurate measurement. This property is of great significance for substance identification and purity judgment.
The compound has optical rotation. Due to the presence of chiral centers in the molecule, the (S) configuration determines the direction and degree of its optical rotation. It can be accurately determined by a polarimeter. The optical rotation has a significant impact in drug development and other fields. Different configurations or have very different biological activities.
In terms of its stability, it can exist stably in a dry environment at room temperature. However, when exposed to high temperature, high humidity or strong light irradiation, or degradation reactions occur, causing structural changes and affecting its properties. In acidic or alkaline environments, stability is also tested, as the molecular structure contains heteroatoms such as nitrogen and sulfur, which can chemically react with acids and bases.

(S) -2,3,5,6-tetrahydro-6-phenylimidazolo [2,1-b] thiazole monohydrochloride, this drug has its uses in many fields. In the field of medicine, it can contribute to the development of new antimalarial drugs. Malaria is a serious threat to human health. This compound may be able to interfere with the metabolic process of Plasmodium or destroy its cell structure by means of its unique mechanism of action, thus achieving antimalarial effect and opening up new paths for malaria treatment.
In the field of organic synthesis, it can be used as a key intermediate due to its unique structure. Organic synthesis aims to create various types of complex organic molecules. This compound can participate in many chemical reactions with its special functional groups and spatial configurations, and help to synthesize organic materials with specific biological activities or physical properties. It also has potential value in the field of materials science.
Furthermore, in pharmaceutical chemistry research, it is like an important probe. By studying its structure modification and activity, researchers can gain insight into the interaction mode between drugs and targets, provide key information for the optimization of drug molecule design, promote the process of innovative drug research and development, and contribute to human health and well-being.

To prepare (S) -2,3,5,6-tetrahydro-6-phenylimidazolo [2,1-b] thiazole monohydrochloride, the synthesis method can be carried out according to the following steps.
First, a suitable starting material, such as a specific aldehyde containing benzene ring and a derivative with a thiazole structure, is added to a suitable reaction medium. This reaction medium may be an organic solvent, such as ethanol, dichloromethane, etc., which can promote the dissolution and reaction of the raw materials. The choice of catalyst is also crucial, or an acid catalyst, such as p-toluenesulfonic acid, or a base catalyst, depending on the specific reaction mechanism.
Under these conditions, a condensation reaction can occur between the starting materials to form a preliminary intermediate. The structure of this intermediate is appropriately adjusted, or its functional groups are optimized through reaction steps such as oxidation and reduction. For example, if you need to adjust the saturation of the carbon-carbon double bond, you can use the method of catalytic hydrogenation, using palladium-carbon as a catalyst, in a hydrogen atmosphere.
Then, for the obtained intermediate, a specific ring structure of imidazole-thiazole needs to be introduced. This step may require more severe reaction conditions such as high temperature and high pressure, with the help of cyclization reagents, the cyclization reaction occurs in the molecule to construct the target imidazolo [2,1-b] thiazole core structure.
After the core structure is formed, the product is in the form of a free base. To obtain a monohydrochloride, the free base product can be dissolved in a suitable solvent, such as ether or ethyl acetate, and dried hydrogen chloride gas is introduced, or an alcoholic solution of hydrogen chloride is added dropwise. The free base is quantitatively reacted with hydrogen chloride to yield (S) -2,3,5,6-tetrahydro-6-phenylimidazolo [2,1-b] thiazole monohydrochloride in the shape of the product. The whole reaction process needs to be closely monitored, and analysis methods such as thin-layer chromatography and nuclear magnetic resonance are used to ensure that the reaction proceeds according to the expected path and the purity and configuration of the product meet the requirements.

Imidazolo [2,1-b] thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S) - The relevant safety precautions are as follows:
Although this compound has a unique chemical structure and potential medicinal value, it must be used with caution as a chemical substance. During operation, professional protective equipment such as protective gloves, goggles and lab clothes is required. Because it is in the form of hydrochloride, it may be corrosive and will cause burns if it comes into contact with the skin or eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention promptly.
Furthermore, the compound should be properly stored in the laboratory environment, away from fire sources and oxidants, because its specific chemical properties may react violently with these substances, causing serious accidents such as fire or explosion. When using, it should be operated in a well-ventilated fume hood to prevent inhalation of its dust or volatile gases, which may irritate the respiratory tract and even cause poisoning.
In addition, after the experiment, its waste should not be discarded at will, and it should be properly disposed of according to the chemical waste treatment process stipulated by the laboratory to avoid pollution to the environment. During the entire operation process involving the compound, the experimenter must strictly follow the established operating procedures and safety guidelines, and always maintain a high degree of vigilance to ensure their own safety and the safety of the experimental environment.