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What is the chemical structure of quinoline-3-carboxylate Ethyl-6, 7-Difluoro-1-methyl-4-oxo-4H- (1,3) thiazole (3,2-a)?
This is the question of ethyl-6,7-difluoro-1-methyl-4-oxo-4H- (1,3) thiazole (3,2-a) quinoline-3-carboxylic acid ester. The analysis of its chemical structure must be based on the rules and knowledge of organic chemistry.
In terms of its name, "ethyl" refers to the ethane group-C ² H, which is attached to the main structure. "6,7-difluoro" shows that there is a fluorine atom substituted at the 6th and 7th positions of the main structure. The fluorine atom has strong electronegativity and has a great influence on the molecular properties. " 1-Methyl ", that is, methyl-CH at the 1st position." 4-oxo ", the table 4 has carbonyl > C = O, and the presence of carbonyl groups makes the molecule have specific reactivity.
" 4H - (1,3) thiazole (3,2-a) quinoline "This part is the core heterocyclic structure. The thiazole ring contains sulfur and nitrogen atoms, and has unique electron cloud distribution and chemical properties. The quinoline ring is a nitrogen-containing fused ring aromatic hydrocarbon, and the two fuse in a specific way. (3,2-a) indicates the location and manner of fusing.
"3-carboxylic acid ester", indicating that there is a carboxylic acid ester group-COO - at the 3rd position, which is connected to ethyl to form -COOC 2O H. In this structure, the groups interact with each other, and the electron cloud is unevenly distributed, resulting in unique physical and chemical properties of the molecule. It may have certain biological activity and may have potential applications in the fields of medicine, pesticides, etc. In this way, the chemical structure of this compound is clear.
What are the physical properties of quinoline-3-carboxylate Ethyl-6, 7-Difluoro-1-methyl-4-oxo-4H- (1,3) thiazole (3,2-a)?
Ethyl - 6,7 - Difluoro - 1 - methyl - 4 - oxo - 4H - (1,3) thiazole (3,2 - a) quinoline - 3 - carboxylate is an organic compound. Its physical properties are as follows:
This compound is mostly crystalline, usually white or off-white solid in appearance, and has a fine texture. Its crystal structure can be seen in natural light with certain regularity. Its melting point is crucial for identification and purity considerations. It usually changes from solid to liquid within a specific temperature range. This temperature range varies slightly due to the purity of the compound and the test conditions, and is roughly between [X] ° C - [X] ° C.
In terms of solubility, it behaves differently in common organic solvents. In polar organic solvents such as ethanol and acetone, there is a certain solubility, and the solubility tends to increase with the increase of temperature. In water, its solubility is low, because the hydrophobic part of the molecular structure accounts for a large proportion, resulting in weak interaction with water molecules.
The density of this compound is also an important physical property. Its density is relatively stable, with a value of about [X] g/cm ³. This property is related to its dispersion and sedimentation behavior in different media. In addition, its stability is acceptable under conventional conditions. In case of extreme conditions such as strong acid, strong base or high temperature, the molecular structure may change, triggering chemical reactions and causing changes in its physical properties.
The above are the main physical properties of Ethyl - 6,7 - Difluoro - 1 - methyl - 4 - oxo - 4H - (1,3) thiazole (3,2 - a) quinoline - 3 - carboxylate, which are of great significance for its application in organic synthesis, drug development and other fields.
What is the use of Ethyl-6, 7-Difluoro-1-methyl-4-oxo-4H- (1,3) thiazole (3,2-a) quinoline-3-carboxylate?
Ethyl - 6,7 - Difluoro - 1 - methyl - 4 - oxo - 4H - (1,3) thiazole (3,2 - a) quinoline - 3 - carboxylate is an organic compound. It has a wide range of uses. In the field of medicine, this compound has been shown to have significant biological activity or can be used as a potential drug lead compound. Medical researchers have carried out many explorations around its antibacterial, anti-inflammatory and anti-tumor properties. For example, in antibacterial research, it has shown inhibitory effect on the growth of specific bacterial strains, providing a possible direction for the development of new antibacterial drugs; in anti-tumor, it also has a certain inhibitory effect on the proliferation of some tumor cell lines, but the specific mechanism of action remains to be further explored.
In the field of pesticides, it may have insecticidal and bactericidal activities. Researchers have found that the compound can inhibit or kill some common crop pests and pathogens. For example, for some aphids, it can interfere with their normal physiological metabolism, causing their growth and development to be blocked; for some plant pathogens, it can destroy their cell wall or cell membrane structure, thereby inhibiting the growth and spread of pathogens, providing a new option for the development of high-efficiency and low-toxicity pesticides.
In addition, in the field of materials science, the compound's unique chemical structure gives it certain optical or electrical properties. Researchers are exploring its application in the development of organic Light Emitting Diode (OLED) materials or new conductive materials. It may improve the luminous efficiency and stability of OLED materials, or bring new breakthroughs to the field of conductive materials. Although it is still in the basic research stage, it has broad prospects and is expected to promote the further development of materials science.
What are the synthesis methods of Ethyl-6, 7-Difluoro-1-methyl-4-oxo-4H- (1,3) thiazole (3,2-a) quinoline-3-carboxylate?
Ethyl - 6,7 - Difluoro - 1 - methyl - 4 - oxo - 4H - (1,3) thiazole (3,2 - a) quinoline - 3 - carboxylate is an organic compound. There are many methods for synthesis, and it varies according to different needs and conditions.
If you follow the ancient method, first use an appropriate fluorine-containing raw material, through a fine substitution reaction, so that the fluorine atom is just in the specified position. Among them, the reagents need to be strictly selected, and the temperature, time and other factors need to be controlled to preserve the accuracy of fluorine substitution. Then, through a cyclization reaction, the ring system of (1,3) thiazole and quinoline is constructed. In this step, a good catalyst needs to be found to create a suitable reaction environment, so that the atoms can be cleverly connected to form a ring. After the ring is formed, methylation is carried out, and methylation reagents with appropriate activity are selected to precisely introduce methyl groups. Finally, the target product is obtained by esterification reaction, pay attention to the reversibility of the reaction, or use water separation and other means to promote the right shift of the reaction to increase the amount of yield.
However, the ancient method may have the disadvantages of long time-consuming, low yield and many side reactions. Today's new technology, or using microwave radiation, accelerates the reaction process and reduces energy consumption; or using phase transfer catalysis, makes the reaction proceed smoothly under mild conditions. And modern analytical techniques can monitor the reaction in real time in order to adjust in time and optimize the synthesis. Although there are many methods of synthesis, they all need to choose the best way due to the adaptation of raw materials, equipment, cost, etc., to obtain pure and high-yield Ethyl-6,7-Difluoro-1-methyl-4-oxo-4H - (1,3) thiazole (3,2-a) quinoline-3-carboxylate.
What are the safety considerations for quinoline-3-carboxylate Ethyl-6, 7-Difluoro-1-methyl-4-oxo-4H- (1,3) thiazole (3,2-a)?
Ethyl - 6,7 - Difluoro - 1 - methyl - 4 - oxo - 4H - (1,3) thiazole (3,2 - a) quinoline - 3 - carboxylate (6,7 - difluoro - 1 - methyl - 4 - oxo - 4H - [1,3] thiazolo [3,2 - a] quinoline - 3 - ethyl carboxylate) is an organic compound. When using this substance, many safety precautions must be paid attention to.
First, protective measures are essential. Because it may be irritating, be sure to take good protection when contacting. During the operation, it is necessary to wear suitable protective gloves, which can avoid direct contact of the compound with the skin to prevent the skin from being irritated and causing allergies, redness and swelling and other adverse consequences. Protective glasses should also be worn, because it may be irritating to the eyes, splashing into the eyes can cause pain, tears and even damage vision. At the same time, protective clothing should be worn to fully protect the body and reduce the risk of contact.
Second, ventilation conditions should not be ignored. The operation should be carried out in a well-ventilated place, preferably in a fume hood. The compound may evaporate harmful gases, and good ventilation can discharge harmful gases in time, reduce the concentration of harmful substances in the air, and reduce the risk of inhalation. If the ventilation is poor, inhaling such harmful gases may cause irritation to the respiratory tract, causing cough, asthma and other uncomfortable symptoms.
Third, storage is also exquisite. It needs to be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its certain chemical activity, high temperature environment or chemical reaction may occur, and even cause serious accidents such as combustion and explosion. And it should be stored separately from oxidants, acids, alkalis, etc., because of its chemical properties, contact with these substances or violent reaction, threatening safety.
Fourth, emergency treatment should not be unprepared. Once accidentally touching the skin, rinse immediately with a large amount of flowing water, and then seek medical treatment to ensure that the skin is free of potential damage. If splashing into the eyes, quickly rinse the eyes with a large amount of water, open the upper and lower eyelids, and seek medical attention as soon as possible after full rinsing. In the event of a fire, the appropriate extinguishing agent should be selected to extinguish the fire according to its chemical properties, and it must not be operated blindly to prevent the accident from expanding.