ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate

Ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate, Chinese name or ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate. This substance has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicine. Due to its special chemical structure, it can endow the prepared drugs with unique biological activity and pharmacological properties. For example, when developing drugs with antibacterial and anti-inflammatory effects, this structural unit is often introduced to enhance the binding ability of the drug to the target, thereby enhancing the efficacy of the drug.
In the field of pesticides, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. With its structural characteristics, pesticide products with high selectivity, high efficiency and low toxicity to pests can be developed, providing powerful means for crop pest control, and can reduce the adverse impact on the environment. In line with the needs of green agriculture development.
In addition, in the field of materials science, it may participate in the synthesis of functional materials. Due to its stable chemical properties and specific photoelectric properties, it is expected to be used in the preparation of optical materials, conductive materials, etc., contributing to the innovative development of materials science.

There are various ways to synthesize ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate. One of the common ones is to start with sulfur-containing compounds, nitrogen-containing compounds and carbonyl compounds, and undergo a change of condensation and cyclization.
If an appropriate thioamide is first taken and placed in a suitable reaction medium with α-halogenated ketones, accompanied by a suitable base agent. The base agent can promote the reaction between the two, and the carbon site connected by the sulfur atom of the thioamide and the halogen atom of the α-halogenated ketone undergoes nucleophilic substitution, and then the molecular cyclization forms the structure of the 1,3-thiazole ring. In this process, the reaction temperature, time and the proportion of reactants are all important factors. If the temperature is too high or the side reactions are clustered, if it is too low, the reaction will be slow; if the ratio is not appropriate, it will be difficult to obtain the best yield.
There is also a method of using 2-amino-4-methyl-5-formylthiazole and ethyl benzoate as raw materials. Under specific conditions, the amino group and ester group can also become the target product through a series of reactions such as condensation. In this case, a catalyst may be introduced to increase the reaction rate and optimize the reaction process. The type and amount of catalyst used are all related to the reaction effect.
Furthermore, a multi-step reaction route can be designed. 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid was synthesized first, and then it was esterified with ethanol under acid catalysis to obtain ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate. When catalyzed by acid, sulfuric acid, p-toluenesulfonic acid, etc. can be selected as catalysts, but it is necessary to pay attention to the requirements of the reaction conditions and the effect on the purity of the product.
All synthesis methods have advantages and disadvantages. The experimenter should choose carefully according to the actual situation, such as the availability of raw materials, cost considerations, and the purity requirements of the product.

"Tiangong Kaiwu" was written by Yingxing in the Ming and Song Dynasties. It contains the details of all kinds of skills and products. However, today I will use ancient words to describe the physical properties of ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate.
This compound has specific properties. Its shape, at room temperature, or in a crystalline state. It has a clear quality when viewed. The crystal form is uniform, reflecting light and shining, like a treasure made in heaven. Its color, or white, is pure like snow, without the disturbance of variegated colors, and shows a pure state.
When it comes to its smell, it smells lightly, or has a light fragrance, but is not rich and intense. It is subtle and elegant, like the quiet fragrance of an orchid, lingering on the nose, giving people a sense of tranquility.
As for its melting point, the melting point is the critical temperature at which the substance changes from solid to liquid. The melting point of this compound is fixed, and when heated to a specific temperature, it begins to melt. Like ice disappearing under the warm sun and slowly turning into a liquid. The same is true for the boiling point. At a certain temperature, the liquid turns into a gaseous state. This is the nature of its boiling point. It is an inherent physical property that can help identify and separate techniques.
In terms of solubility, it may have different manifestations in organic solvents. In alcoholic solvents, such as ethanol, or soluble, just like salts melt in water and disperse uniformly to form a uniform system. In hydrocarbon solvents, such as n-hexane, or poor solubility, if the two are oil and water, it is difficult to blend, and each is a state.
Density is also one of its physical properties. Compared with water, or there is a difference in weight, you can know the density according to its fluctuation in water. This is the key to distinguishing physical properties, and it is important for experimental and industrial applications.

Guanfu "ethyl + 4 - methyl - 2 - phenyl - 1,3 - thiazole - 5 - carboxylate", this is the name of an organic compound. To know whether its chemical properties are stable, it is necessary to analyze its structure.
This compound contains a thiazole ring, which has a certain stability because its conjugate system can disperse the electron cloud and reduce the molecular energy. The nitrogen and sulfur atoms in the ring have lone pairs of electrons and can participate in a variety of chemical reactions, such as coordination with metal ions. However, this does not mean that it is unstable, but only indicates that it has a reactive activity check point. < Br >
The benzene ring structure also contributes to the stability. The benzene ring is a highly conjugated planar structure with high delocalization of π electrons and low energy. And the substituents on the benzene ring will affect the electron cloud distribution and reactivity, but the whole is still a stable structural unit.
Looking at the ethyl ester group, this is a relatively stable functional group. However, under certain conditions, such as strong acid or strong base environment, the ester group can undergo hydrolysis reaction. Under neutral or mild conditions, its stability is acceptable.
4-methyl substituent has little effect on the overall stability, mainly changing the electron cloud distribution and steric resistance of the molecule.
Overall, under conventional conditions, the chemical properties of "ethyl + 4 - methyl - 2 - phenyl - 1,3 - thiazole - 5 - carboxylate" are relatively stable. When encountering strong acids, strong bases, high temperatures or specific catalysts, chemical reactions can occur in the thiazole ring, ester group and other parts, and the stability is affected.

I look at your question, but I am inquiring about the price of ethyl + 4 - methyl - 2 - phenyl - 1,3 - thiazole - 5 - carboxylate in the market. However, the price of this product in the market is difficult to say. The price often changes due to various reasons.
First, the purity of this compound is very important. If the purity is very high and the preparation is difficult, the price will be high; if the purity is slightly inferior and the preparation is easier, the price will be cheap.
Second, the state of supply and demand is also the key. If there are many applicants in the market and there are few suppliers, the price will rise; if the supply exceeds the demand, the price will fall.
Third, the preparation method and cost also have an impact. If the preparation requires rare raw materials, or the process is complicated and the cost is high, the price will be high; if the raw materials are easy to obtain, the process is simple, and the cost is low, the price will be low.
Fourth, the manufacturer and the brand can also make a difference in price. Well-known manufacturers, those with good quality, the price may be high; unknown manufacturers, those with unknown quality, the price may be low.
I have not obtained the exact price, but if you want to know the price of this product, you can visit the platform for trading chemical products, or consult the supplier of chemical raw materials, who may be able to give you a more accurate price.