ethyl 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylate

Ethyl 4 - methyl - 2 - (4 - (trifluoromethyl) phenyl) thiazole - 5 - carboxylate, Chinese name ethyl 4 - methyl - 2 - (4 - (trifluoromethyl) phenyl) thiazole - 5 - carboxylate, this substance has a wide range of uses.
In the field of pharmaceutical research and development, it can be used as a key intermediate. The structure of Gainthiazole and trifluoromethylbenzene endows the compound with unique physicochemical and biological activities. Based on this, chemists can carefully construct compounds with more complex structures. After modification and optimization, it is expected to find lead compounds with excellent pharmacological activity, paving the way for the creation of new drugs. For example, it may be able to target specific disease-related targets, showing high affinity and selectivity, and then developing drugs with good efficacy and few side effects.
In the field of pesticides, ethyl 4-methyl-2- (4- (trifluoromethyl) phenyl) thiazole-5-carboxylate also has a place. Due to its special structure, it may have the ability to inhibit or kill certain pests and pathogens. Using it as a raw material, environmentally friendly, efficient and low-toxicity pesticide varieties can be developed, which can help agricultural harvest and reduce the adverse impact on the ecological environment.
Furthermore, in the field of materials science, this compound can be used as a building block for functional materials. With its unique electronic properties and spatial structure, it can participate in the synthesis of materials with special optical and electrical properties, such as materials for organic Light Emitting Diodes (OLEDs), sensors and other fields, contributing to the development of materials science.

There are currently compounds ethyl 4 - methyl - 2 - (4- (trifluoromethyl) phenyl) thiazole - 5 - carboxylate, and we want to know the method of synthesis. Synthesis of this compound usually follows the common method of organic synthesis and achieves the purpose through multi-step reaction.
The choice of starting materials is quite critical. You can first use 4- (trifluoromethyl) benzaldehyde with compounds containing sulfur and nitrogen, such as thioacetamide, to form intermediates containing thiazole rings through condensation reaction. This condensation reaction may require an appropriate solvent, such as ethanol, toluene, etc., using an acid or base as a catalyst to control the temperature and reaction time, so that the nucleophilic addition, cyclization and other steps occur to construct the structure of the thiazole ring.
The obtained thiazole ring-containing intermediate is esterified. After activation of a carboxyl-containing compound, such as conversion to an acyl chloride, ethanol and an appropriate acylating agent, such as a carboxyl-containing compound, are esterified with the carboxyl group of the intermediate under alkali catalysis to generate the target product ethyl 4 - methyl - 2 - (4 - (trifluoromethyl) phenyl) thiazole - 5 - carboxylate. In the reaction, the alkali can be selected from pyridine, triethylamine, etc., to maintain the alkaline environment of the reaction system and promote the smooth progress of the esterification reaction.
There may also be other methods, such as first constructing part of the structure of the thiazole ring, and then introducing 4 - (trifluoromethyl) phenyl group, and finally completing the esterification. The specific operation depends on the availability of starting materials, the difficulty of controlling the reaction conditions, and the high or low yield. The synthesis path needs to be carefully controlled at each step to achieve a good synthesis of the target product.

Ethyl-4-methyl-2- (4- (trifluoromethyl) phenyl) thiazole-5-carboxylic acid ester is an organic compound. According to its physical properties, it is mostly in a solid state under normal temperature and pressure. Due to the strong interactions between molecules, such as van der Waals force and possible hydrogen bonding, the molecules are closely arranged and appear in a solid state.
When it comes to the melting point, although there is no exact literature to directly describe the melting point of this specific compound, the melting point may be within a certain range based on similar compounds containing thiazole rings and aryl and ester groups. The rigid structure of thiazole rings and the conjugated system of aryl groups make the molecular stacking more regular and can increase the melting point. The existence of the ester group, or the change of the intermolecular force, affects the exact value of the melting point, which may be between tens and 200 degrees Celsius.
Its solubility is also an important physical property. The compound contains groups such as ester group, methyl group and trifluoromethyl group. The ester group has a certain polarity, but the methyl group and trifluoromethyl group are non-polar groups. In organic solvents, because of its partially non-polar structure, it may be soluble in common non-polar or weakly polar organic solvents, such as chloroform, dichloromethane, etc. This is due to the principle of "similar miscibility", the non-polar part interacts with the non-polar solvent to help it dissolve. However, in water, due to its limited overall polarity and the large proportion of non-polar groups, its solubility is poor and it is difficult to dissolve in water.
In addition, the density of the compound is also worth discussing. Although there is no measured data, it is estimated that the molecules contain elements with relatively large atomic mass such as sulfur and fluorine, and the compactness of the molecular structure, so their density may be higher than that of water. Because of the relatively high mass of the compound molecules per unit volume, its density is higher.
In summary, the physical properties of ethyl-4-methyl-2 - (4- (trifluoromethyl) phenyl) thiazole-5 -carboxylic acid esters are influenced by their unique molecular structure, presenting solid state, specific melting point range, specific solubility, and relatively large density.

Ethyl 4 - methyl - 2 - (4- (trifluoromethyl) phenyl) thiazole - 5 - carboxylate, this is an organic compound with unique chemical properties.
Its appearance is usually a crystalline solid or a colorless to light yellow liquid, which shows certain physical properties due to the presence of specific atoms and groups. The melting point, boiling point and other properties depend on the intermolecular forces. The intermolecular forces caused by aromatic rings and fluorine atoms are different, which affect the melting boiling point.
In terms of solubility, the compound has a certain solubility in organic solvents such as dichloromethane, chloroform, and toluene. Due to the principle of similar miscibility, its organic structure is miscible with organic solvents; its solubility in water is limited, because its hydrophobic aromatic ring and fluorine substituent account for a large proportion, which is different from water polarity.
In terms of chemical stability, C-C, C-H, C-N, C-S and other bonds in the molecule are relatively stable, but they can react under specific conditions. The nitrogen and sulfur atoms on the thiazole ring have solitary pairs of electrons, so that the ring has a certain nucleophilicity and can react with electrophilic reagents. Ester-COOEt is the active check point, which can be hydrolyzed in case of acid or base. Under acid catalysis, carboxylic acid and ethanol are generated; alkali catalyzed hydrolysis is more thorough, and carboxylate and ethanol are obtained.
On the aromatic ring, 4- (trifluoromethyl) phenyl part, trifluoromethyl has strong electron-absorbing properties, which affects the electron cloud density of the aromatic ring, so that the activity of the aromatic ring electrophilic substitution reaction changes. The check point of the electrophilic substitution reaction is different from that without this substituent. Usually, the electron cloud density of the ortho and para-position is affected, and the electrophilic reagents are more likely to attack the interposition.
In addition, methyl, trifluoromethyl and other alkyl groups and fluorine-containing groups in this compound can participate in free radical reactions. Under specific conditions, C-H bonds can be homogenized to generate free radicals and participate in subsequent free radical-induced chain reactions. Its chemical properties are rich and may have potential application value in the fields of organic synthesis and medicinal chemistry.

I don't know the price range of ethyl 4 - methyl - 2 - (4 - (trifluoromethyl) phenyl) thiazole - 5 - carboxylate in the market. This compound is not a common and well-known thing, and the market price often varies due to many factors.
If you want to know its price, you need to look for various ways. First, you can visit the website of the chemical reagent supplier, where many merchants list the price of the product, or you can find the price of this compound. Second, ask practitioners in the chemical industry, such as researchers in scientific research institutions, laboratory experimenters, etc., who may be familiar with the price of such compounds because of their work. Third, refer to the relevant chemical product trading platforms, which collect a lot of chemical product transaction information, or have price traces of this compound.
However, it should be noted that the purity, packaging specifications, purchase quantity, etc. of this compound have a great impact on the price. The higher the purity, the higher the price; the different the packaging specifications, the different the price; the more the purchase quantity, the merchant may reduce the unit price due to the large quantity discount. And the market price fluctuates constantly, from high to low, so the exact price should be subject to real-time inquiry.