Ethyl 2-methylthiazole-5-carboxylate

Ethyl-2-methylthiazole-5-carboxylic acid ester, this is an organic compound. It is widely used in the field of medicine and can be used as a key intermediate to synthesize drugs. In the process of many drug research and development, it contributes a lot to the shaping of drug activity and characteristics by virtue of its unique chemical structure. In the creation of pesticides, it also plays an important role, and may become a key component in the synthesis of high-efficiency and low-toxicity pesticides, helping to improve the efficacy and safety of pesticides.
In the fragrance industry, ethyl-2-methylthiazole-5-carboxylic acid esters can be added to fragrance formulations to give products a unique aroma. Due to its special structure, it contributes a unique aroma and is indispensable when blending characteristic fragrances.
Furthermore, in the field of organic synthesis chemistry research, it is often used as a starting material or intermediate to construct more complex organic molecular structures. Chemists use various reactions to derive a variety of compounds, expand the chemical boundaries of organic synthesis, and lay the foundation for the development of new materials. In short, ethyl-2-methylthiazole-5-carboxylic acid esters have key value and wide use in many fields.

The methods for the synthesis of ethyl 2-methylthiazole-5-carboxylic acid esters in the past are about the following.
First, 2-methyl-5-bromothiazole is co-reacted with potassium cyanide to form 2-methylthiazole-5-formonitrile, and then hydrolyzed and esterified. During the cyanidation process, caution is required. Because of the highly toxic cyanide involved, the operating environment must be well ventilated, and the reaction conditions must be strictly controlled, such as temperature, time, and the proportion of reactants. When hydrolyzing, proper selection of hydrolysis reagents and reaction temperatures can affect the purity and yield of the product. In the esterification step, suitable alcohols and catalysts are selected to make the reaction proceed smoothly and improve the output of the target product.
Second, using 2-methyl-5-aldehyde thiazole as the starting material, 2-methylthiazole-5-carboxylic acid is oxidized to obtain 2-methylthiazole-5-carboxylic acid, and then esterified with ethanol catalyzed by acid. In the oxidation stage, it is crucial to select the appropriate oxidant, and the strength of its oxidation ability directly affects the selectivity and purity of the product. In the esterification reaction, the type and amount of acid catalyst, as well as the moisture control of the reaction system, have significant effects on the reaction process and results. < Br >
Third, it is prepared from 2-amino-4-methylthiazole and diethyl oxalate through condensation reaction. In this process, the condensation reaction conditions are quite critical, such as the choice of reaction solvent, the type and amount of base, which will affect the rate of the reaction and the structure of the product. It is necessary to precisely control the reaction parameters to make the reaction proceed efficiently in the direction of generating the target product, and attention should be paid to the occurrence of side reactions to avoid the formation of impurities to ensure the quality and purity of the product.

Ethyl + 2 - methylthiazole - 5 - carboxylate, Chinese name ethyl 2 - methylthiazole - 5 - carboxylate. This physical property belongs to the category of organic compounds, let me tell you one by one.
Its appearance is often colorless to light yellow liquid, with a special smell, but this smell is not pleasant, and ordinary people smell it or feel uncomfortable. Because its structure contains thiazole ring and ester group, it has unique physical properties.
When it comes to boiling point, it is about a specific temperature range. Due to intermolecular forces, van der Waals forces and some weak interactions, it needs corresponding energy to overcome before it can be converted from liquid state to gaseous state. The melting point is also within a certain range, reflecting the transition temperature between solid and liquid states.
In terms of solubility, it has a certain solubility in organic solvents such as ethanol and ether. Interactions such as van der Waals forces and hydrogen bonds can be formed between its molecular structure and organic solvent molecules to promote dissolution; however, the solubility in water is not good, because its non-polar part is relatively large, and the polarity difference with water is large, which does not conform to the principle of "similar miscibility".
The density is different from that of water. When placed in water, it may float or sink, depending on the relative size of its density with water. The refractive index of this compound also has a specific value. The refractive index reflects the change of the speed of light propagation in it, which is closely related to the molecular structure and arrangement.
In summary, the physical properties of ethyl 2-methylthiazole-5-carboxylic acid ester are determined by its molecular structure, and it has important application value in organic synthesis, medical chemistry and other fields due to these physical properties.

Ethyl 2-methylthiazole-5-carboxylate (ethyl 2-methylthiazole-5-carboxylate) is an organic compound with unique chemical properties.
In terms of physical properties, it is mostly liquid at room temperature and has a specific smell and color. Due to the ester group, it has certain solubility. It is soluble in some organic solvents such as ethanol and ether, and its solubility in water is poor.
In terms of chemical properties, the ester group is the key active site and can undergo hydrolysis. Under acidic conditions, hydrolysis produces 2-methylthiazole-5-carboxylic acid and ethanol; under basic conditions, hydrolysis is easier and more thorough, and the products are carboxylate and ethanol. At the same time, because of its thiazole ring, it is aromatic and can undergo electrophilic substitution reactions, such as halogenation, nitrification, etc. The reactivity is different from that of benzene ring, and the substitution position is affected by the localization effect of the substituent on the ring. In addition, the hydrogen atom on the carbon linked to the methyl group has a certain activity, and can undergo related reactions under the action of strong bases, such as the formation of carbon negative ions, and then participate in nucleophilic substitution or addition reactions.
This compound is widely used in the field of organic synthesis and can be used as a key intermediate for the preparation of bioactive compounds. It plays an important role in the creation of medicine and pesticides, and is also used in the synthesis of organic materials with special structures.

I do not know the exact price range of "Ethyl 2 - methylthiazole - 5 - carboxylate" in the market. This compound is an important intermediate in organic synthesis and is often used in the fields of medicine, pesticides and materials science. Its price often varies due to many factors such as purity, yield, market supply and demand situation.
If the purity is ordinary, it can be used in a small amount in the laboratory, and the price per gram may be around tens of yuan to 100 yuan. However, if it is high purity and applied to high-end pharmaceutical research and development, the price may rise sharply, reaching hundreds of yuan per gram or even higher.
Furthermore, when purchasing in bulk, the unit price may decrease due to the scale effect. If a large number of purchases are made in the chemical raw material market, the price range per ton may vary widely depending on the purchase volume.
And market prices fluctuate frequently, if you want to know the exact price, you can consult chemical product suppliers, chemical trading platforms, or research at relevant industry exhibitions to obtain the current exact price range.