ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate

Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate (2-bromo-4-methyl-1,3-thiazole-5-carboxylate) is widely used in the field of organic synthesis.
Bearing the brunt, it is a key building block for the construction of complex nitrogen-containing heterocyclic compounds. Nitrogen-containing heterocyclic rings play a pivotal role in pharmaceutical chemistry, materials science and other fields. From the perspective of drug development, many bioactive molecules contain such heterocyclic structures. With the reactivity of its bromine atom and carboxyethyl ester group, this compound can undergo various reactions such as nucleophilic substitution and coupling, and then form a heterocyclic structure with various nucleophilic reagents, laying the foundation for the creation of new drugs.
Furthermore, it also has wonderful uses in material synthesis. After appropriate chemical reaction modification, specific functional groups can be introduced to endow the material with unique optical, electrical or mechanical properties. For example, through the construction of conjugated systems, it is expected to prepare materials with excellent photoelectric properties for use in organic Light Emitting Diodes (OLEDs), solar cells and other devices, thus opening up broad application prospects in the field of advanced materials.
In addition, in the field of agricultural chemistry, such compounds and their derivatives may be used as synthetic precursors for new pesticides. After structural modification and optimization, they may exhibit excellent insecticidal, bactericidal or herbicidal activities, and may be more selective and environmentally friendly than traditional pesticides, contributing to the development of green agriculture. In short, ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate has great potential in many fields of organic synthesis and is one of the important substances in the research and application of organic chemistry.

The synthesis of ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylic acid esters has also been explored in the past. The method is roughly as follows:
First, use suitable sulfur-containing compounds and haloacetyl derivatives as starting materials. First, sulfur-containing compounds, such as thiourea with specific substituents, are reacted with haloacetyl derivatives in suitable solvents and catalyzed by bases. The base can be selected from potassium carbonate, such as ethanol and acetone. This reaction aims to build the basic structure of thiazole rings. When reacting, it is necessary to pay attention to the control of temperature and reaction time. Generally, the temperature is controlled in a moderate range, such as 50-80 degrees Celsius, and the reaction is carried out for several hours, so that the reaction can be fully carried out to form the preliminary thiazole ring intermediate.
Second, the obtained intermediate is brominated and modified. Brominating reagents such as N-bromosuccinimide (NBS) are often used. The intermediate is dissolved in a suitable inert solvent, such as dichloromethane, and an appropriate amount of N-bromosuccinimide is added to react at low temperature or room temperature. When reacting at low temperature, the temperature can be maintained at 0-10 degrees Celsius, and the room temperature is about 20-30 degrees Celsius. During the reaction process, the reaction process needs to be monitored. Thin-layer chromatography (TLC) and other means can be used. After the reaction is complete, the pure brominated intermediate is obtained by separation and purification methods, such as column chromatography.
Third, on the basis of brominated intermediates, ethyl ester is introduced. Halogenated ethyl acetate is used as a reagent to react with brominated intermediates under alkaline conditions. The base can be selected as a strong base such as sodium hydride and reacted in an anhydrous organic solvent such as tetrahydrofuran. The reaction temperature also needs to be finely regulated. Generally, it starts at a low temperature and gradually warms up to a moderate temperature. For example, the reaction takes a period of time before - 10 - 0 degrees Celsius, and then slowly warms up to room temperature. The reaction takes several hours to promote the successful integration of ethyl ester, and finally ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate. After the reaction, the product is purified through extraction, drying, distillation and other steps to achieve higher purity.

Ethyl ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate, this is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it may be a solid or a viscous liquid, but its color may be colorless or yellowish, depending on the purity and impurity situation.
Smell, or have a special organic odor, but the intensity and specific characteristics of this odor must be carefully screened by professional experiments.
As for the melting point and boiling point, the melting point or at a specific temperature range, the exact value must be determined by experiment. Its boiling point is also determined by factors such as intermolecular forces, relative molecular mass, etc., and under standard atmospheric pressure, or an exact boiling point value is stored, but the external pressure changes, and the boiling point also changes.
In terms of solubility, in view of its organic structure, it may exhibit good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This is due to the principle of "similar miscibility", and its organic groups and organic solvent molecules can form a suitable force. However, in water, its solubility may not be good, due to limited molecular polarity and weak interaction with water molecules.
Density may be different from water, or greater than water, or less than water, which is also one of its important physical properties and can be accurately determined by experimental methods.
In summary, the physical properties of ethyl-2-bromo-4-methyl-1,3-thiazole-5-carboxylate are rich and diverse, and in-depth understanding of it is of great significance in many fields such as organic synthesis and drug development.

Ethyl-2-bromo-4-methyl-1,3-thiazole-5-carboxylic acid ester, this is an organic compound. Looking at its chemical properties, its molecular structure contains thiazole ring, bromine atom, methyl and carboxylic acid ethyl ester group, and these structures endow it with unique properties.
First talk about its stability. The structure of the thiazole ring is relatively stable, but the existence of the bromine atom, due to the large electronegativity of bromine, causes the C-Br bond to have a certain polarity, so that under certain conditions, the bond is easily broken and exhibits active chemical activity.
Let's talk about its reactivity. First, nucleophilic substitution reaction. The bromine atom is a good leaving group. When encountering nucleophiles, such as alcohols and amines, it is prone to nucleophilic substitution, and the bromine atom is replaced by a nucleophilic reagent group. For example, when reacting with alcohols under basic conditions, ether derivatives may be formed; when reacting with amines, amine substitution products may be formed. Second, the reaction of ester groups. The hydrolysis of ethyl carboxylate groups can occur. In acidic or basic environments, ester bonds are broken to form carboxylic acids and ethanol, respectively. Hydrolysis is more complete under basic conditions, called saponification reaction. Third, the reaction of thiazole rings. The hydrogen atom on the thiazole ring can undergo a substitution reaction under specific conditions. Due to the electron cloud distribution characteristics of the thiazole ring, the hydrogen at a specific position has a certain activity and can be replaced by other groups.
In terms of solubility, due to the fact that its molecules contain polar groups such as ester groups and non-polar parts such as methyl groups, it has a certain solubility in some organic solvents, such as ethanol and acetone, but relatively small solubility in water, because the whole is not a strongly polar molecule.
In terms of thermal stability, under normal heating conditions, the compound may remain relatively stable, but when the temperature is too high, weak links such as C-Br bonds may change first, causing changes in molecular structure and even decomposition.

I look at your question, it is ethyl-2-bromo-4-methyl-1,3-thiazole-5-carboxylic acid ester in the market price range. However, the price of this compound is difficult to determine. The price varies depending on many factors.
First, it is related to purity. If the purity is very high and almost flawless, its price will be high; if it contains impurities, the price will be slightly lower.
Second, it depends on supply and demand. If the demand for this product is strong and the supply is scarce, the price will rise; if the supply exceeds the demand, the price may decline.
Third, it is related to the manufacturer. Different manufacturers have different processes and different costs, so their pricing varies.
Fourth, the amount purchased also has an impact. If you buy in large quantities, there may be discounts, and the unit price is lower; if you buy in small quantities, the price may be higher.
According to past transactions and market conditions, the price of this compound per gram may be lower or several dozen yuan. If the purity is extremely high and the demand is urgent, it can reach several hundred yuan per gram. However, this is only a rough estimate, and the actual price should be subject to the quotation of each supplier. For accurate prices, you can consult chemical reagent suppliers, or inquire on relevant chemical trading platforms to obtain their details.