Ethyl 2-aminothiazole-5-carboxylate

Ethyl 2-aminothiazole-5-carboxylate is an organic compound. In terms of its structure, it contains a thiazole ring, with a 2-position amino group and a 5-position carboxylate ethyl group on the ring. This structure gives it unique chemical properties.
In terms of physical properties, it is usually a solid, but due to differences in molecular forces, the melting point is different. And because it contains polar groups, it can have certain solubility in polar solvents such as ethanol and acetone, but poor solubility in non-polar solvents such as n-hexane.
In terms of chemical properties, amino groups are basic and can react with acids to form salts. In the case of hydrochloric acid, the lone pair of electrons of the amino nitrogen atom can accept protons and form ammonium salts. This property makes it ionizable in an acidic environment, affecting its solubility and reactivity.
Carboxylic acid ethyl ester group has the typical properties of esters and can undergo hydrolysis reaction. Under acidic conditions, hydrolysis generates 2-aminothiazole-5-carboxylic acid and ethanol; under basic conditions, hydrolysis is easier to carry out, generating carboxylic salts and ethanol. This hydrolysis reaction is often used in organic synthesis to introduce carboxyl groups.
Thiazole ring also has special reactivity and can undergo electrophilic substitution. Due to the lone pair electrons of nitrogen and sulfur atoms on the ring, the density of the ring electron cloud increases, making it more vulnerable to electrophilic attack. If it reacts with electrophilic reagents such as bromine, bromine atoms can be introduced at suitable positions on the ring, laying the foundation for the subsequent synthesis of complex compounds.
Ethyl 2-aminothiazole-5-carboxylate has important application value in the fields of pharmaceutical chemistry and organic synthetic chemistry due to these chemical properties, and can be used as a key intermediate for the synthesis of many biologically active compounds.

Ethyl 2-aminothiazole-5-carboxylate is synthesized by the husband.
First, it is condensed on thiourea with 2-bromoacetaldehyde to form 2-aminothiazole first, and then esterified to obtain Ethyl 2-aminothiazole-5-carboxylate. First, the thiourea is placed in an appropriate solvent, such as ethanol, and stirred to dissolve. Then slowly add 2-bromoacetaldehyde to control the reaction temperature, usually at a moderate temperature, such as between 40-60 degrees Celsius, so that it is fully condensed to obtain 2-aminothiazole. Then, 2-aminothiazole is reacted with a suitable esterification reagent, such as a mixture of ethanol and concentrated sulfuric acid, under the condition of heating and reflux. Concentrated sulfuric acid can be used as a catalyst to promote the esterification reaction to occur, and the final product is obtained.
Second, 2-mercaptoacetamide and α-bromoester can also be used as raw materials. First, 2-mercaptoacetamide is mixed with a base, such as sodium hydroxide, in a solvent to form a corresponding salt. Then α-bromoester is added. In the reaction system, the base can promote the nucleophilic substitution reaction, the mercapto group attacks the α-carbon of α-bromoester, and the bromine ion leaves to form an intermediate. This intermediate is then cyclized to form the structure of 2-aminothiazole-5-carboxylate. After appropriate treatment, such as acidification, purification, etc., Ethyl 2-aminothiazole-5-carboxylate can be obtained.
Third, you can also start from 5-formyl-2-aminothiazole. With 5-formyl-2-aminothiazole and an appropriate alcohol, in the presence of a catalyst, such as p-toluenesulfonic acid, at a suitable temperature, such as 80-100 degrees Celsius, acetalization is carried out to form the corresponding acetal first. Then oxidizing agents, such as Jones reagent, oxidize the acetal to the corresponding carboxylate, and finally get Ethyl 2-aminothiazole-5-carboxylate.
All synthesis methods have their own advantages and disadvantages. It depends on the availability of raw materials, the difficulty of controlling the reaction conditions, and the high or low yield.

Ethyl-2-aminothiazole-5-carboxylic acid ester, which is widely used. In the field of medicine, it is a key organic synthesis intermediate. It is used as the starting material for the preparation of many drugs. Through a series of chemical reactions, complex compound structures with specific pharmacological activities can be constructed. For example, in the development and synthesis of antibacterial drugs, it plays a cornerstone role, providing a key structural basis for the development of new antibacterial drugs, helping to improve the inhibitory and killing effects of drugs on pathogens.
In the field of pesticides, ethyl-2-aminothiazole-5-carboxylic acid esters also show important value. It can be used as an important component in the synthesis of high-efficiency and low-toxicity pesticides. By reasonably combining with other chemical substances, pesticide products with targeted killing or repelling effects on crop pests can be prepared, which helps to ensure the growth of crops, improve the yield and quality of agricultural products, and reduce the negative impact on the environment.
In the field of materials science, it has also been involved. In the synthesis process of some functional materials, its special chemical structure and reactivity will be used to endow the materials with unique properties, such as some materials with special optical and electrical properties. By introducing this material, the molecular arrangement and electronic cloud distribution of the material can be optimized, thereby improving the material-related properties to meet the needs of special functional materials in different fields.

Ethyl 2-aminothiazole-5-carboxylate, Chinese name ethyl 2-aminothiazole-5-carboxylate, this product is at market price, and the current market situation does not have a conclusive and detailed price list. However, looking at the way of discussing things in the past "Tiangong Kaiwu", although there is no direct record of it, you can follow its method of observing things.
In the past, if you want to know the price of things, you need to look at their supply and demand, origin, and difficulty in making them. Ethyl 2-aminothiazole-5-carboxylate, if its preparation method is complicated, the raw materials required are rare, and there are many people who ask for it, its price must be high. If the preparation is easy, the raw materials are widely distributed, and there are few people seeking, the price will be inexpensive.
Looking at today's chemical market, such organic compounds, or due to their specialized use, are often used in specific industries, such as the field of pharmaceutical synthesis. If the pharmaceutical industry is booming and the research and development of new drugs requires this as a material, their demand will be prosperous, and the price will also increase. And the distance of the origin and the difficulty of transportation are all related to the price. If the origin is remote and the transportation is difficult, the price to the market will be added to the cost of freight and other costs, and the price will also be high.
If you want to know its market price, you should consult chemical raw material suppliers, chemical product trading markets, or recent industry reports and price indices to obtain accurate figures, which cannot be determined by speculation.

Ethyl 2-aminothiazole-5-carboxylate, that is, ethyl 2-aminothiazole-5-carboxylate, there are several important things to pay attention to when storing and transporting this product.
First, it is related to the storage environment. It should be stored in a cool, dry and well-ventilated place. Because the cool environment can avoid the chemical properties of it due to excessive temperature. If it is heated, it may cause reactions such as decomposition, which will damage its quality. The dry place is crucial because it is resistant to moisture, water or hydrolysis, which will affect its purity and performance. Good ventilation can disperse volatile gases that may accumulate and prevent potential safety risks.
Second, the packaging must be tight. Appropriate packaging materials, such as sealed containers, are required to prevent air, moisture and impurities from invading. The packaging material should be corrosion-resistant and do not chemically react with the substance to ensure its stability during storage.
Third, when transporting, ensure that the container is stable and prevent collision and dumping. Substances leak due to violent vibration or collision or damage to the package. And the transportation environment should also be temperature-controlled and moisture-proof, and conditions similar to the storage environment should be maintained to ensure the quality during transportation.
Fourth, it should be stored and transported separately from oxidizing, acidic, alkaline and other substances. Due to its chemical properties, contact with the above substances, or cause dangerous chemical reactions, such as oxidation, acid-base neutralization, etc., not only damage itself, but also may lead to safety accidents.
Fifth, fireworks should be strictly prohibited in storage and transportation areas. Ethyl 2-aminothiazole-5-carboxylate or flammable, in case of open flames, hot topics can cause combustion or even explosion, so fire prevention is essential.
All of these are to be paid attention to when storing and transporting Ethyl 2-aminothiazole-5-carboxylate, so as to ensure its quality and safety.