ethyl 2-amino-5-chloro-1,3-thiazole-4-carboxylate hydrochloride

"Tiangong Kaiwu" is an ancient scientific and technological masterpiece in our country, but the inquiry is "ethyl+2-amino-5-chloro-1, 3-thiazole-4-carboxylate+hydrochloride", which is the English name of modern chemical substances, which is explained in Chinese, that is, 2-amino-5-chloro-1,3-thiazole-4-carboxylate ethyl ester hydrochloride, which is not the cognitive category of the era in which "Tiangong Kaiwu" is located, so it is difficult to answer according to its style. However, only in terms of the physical properties of the substance, this compound may be a crystalline solid with a certain melting point and boiling point. Because of the hydrochloride part, it may have good solubility in water and can be dissociated into corresponding ions, showing the characteristics of electrolytes. And because its structure contains a variety of functional groups such as thiazole ring, amino group, chlorine atom and ester group, different functional groups interact with each other, resulting in its unique physical properties. Its appearance may vary depending on the purity and preparation method. High purity may be white to off-white crystals. If it contains impurities, the color may change. And due to intermolecular forces, its solubility in organic solvents also varies, or it has a certain affinity for specific organic solvents.

There are several common methods for the synthesis of ethyl 2-amino-5-chloro-1,3-thiazole-4-carboxylic acid hydrochloride.
First, a thiazole ring can be constructed from a suitable starting material through a multi-step reaction. First, a compound containing sulfur and nitrogen reacts with a halogen to form a thiazole ring precursor. For example, a sulfur-containing compound reacts with a specific halogenated hydrocarbon in a suitable solvent, such as ethanol and dichloromethane, under the action of a base, such as potassium carbonate and triethylamine, a nucleophilic substitution reaction occurs, and the skeleton of the thiazole ring is initially formed. Subsequent modifications are made to the substituents on the ring, chlorine atoms are introduced by halogenation reaction, and amino groups and carboxyl groups can also be introduced through reaction in suitable steps, and finally an ester is formed and reacted with hydrochloric acid to obtain the hydrochloride salt of the target product.
Second, it can also start from compounds with partial structures. For example, using raw materials containing thiazole rings and partial substituents, through selective functional group conversion reactions. Using common reactions in organic synthesis, such as nucleophilic addition and elimination reactions, the desired amino groups, chlorine atoms, and carboxylethyl ester groups are gradually introduced. During operation, precise control of reaction conditions, such as temperature, reaction time, and proportion of reactants, etc. Too high or too low temperature may affect the selectivity and yield of the reaction. If the reaction time is too short, the reaction of the raw materials may be incomplete; if it is too long, it may cause side reactions.
Furthermore, biosynthesis has also been tried. Using a specific enzyme or microbial system, the synthesis of the compound is achieved through the metabolic pathway in the organism. This method is green and environmentally friendly, highly selective, but it requires a high degree of biological system. It requires screening suitable enzymes or microorganisms, and it is difficult to precisely control the culture and reaction conditions.

Ethyl-2-amino-5-chloro-1,3-thiazole-4-carboxylic acid hydrochloride has a wide range of uses and has important applications in the chemical and pharmaceutical fields.
In the chemical industry, it can be used as a key intermediate in organic synthesis. With its unique chemical structure, it can participate in a variety of chemical reactions to prepare other complex organic compounds. For example, by condensation reactions with specific reagents, new carbon-carbon bonds or carbon-heteroatomic bonds can be formed, thus laying the foundation for the synthesis of materials with special properties. In the preparation of certain high-performance polymers or functional materials, the intermediates derived from this compound can impart unique physical and chemical properties to the material, such as improving the stability, solubility or reactivity of the material.
In the field of medicine, its significance is also extraordinary. Because of its structure, amino groups, chlorine atoms and thiazole rings may interact with specific targets in organisms. Therefore, it is often regarded as a lead compound for drug development. Researchers can optimize its pharmacological properties through modification and modification based on the basic structure of this compound, such as improving its affinity and selectivity to specific disease targets and reducing toxic and side effects. Or it can be used to synthesize new drugs with antibacterial, anti-inflammatory or anti-tumor activities, playing an important role in human health.
This compound has attracted much attention due to its significant value in chemical synthesis and pharmaceutical research and development, and has become an important object of many scientific research and industrial production explorations.

Ethyl-2-amino-5-chloro-1,3-thiazole-4-carboxylic acid hydrochloride is a very important chemical substance, and many matters need to be paid attention to during storage.
First, the control of temperature and humidity is crucial. This substance should be stored in a cool, dry place. If the temperature is too high, it may cause changes in its chemical properties, resulting in decomposition or deterioration; if the humidity is too high, it will easily cause it to absorb moisture and affect the purity and stability. Therefore, the warehouse temperature should be maintained between 15 ° C and 25 ° C, and the relative humidity should be 40% to 60%.
Second, it is necessary to pay attention to the influence of light. The substance is quite sensitive to light, and long-term exposure to light may trigger photochemical reactions, which in turn change its structure and properties. Therefore, it should be stored in a dark place, such as in a brown bottle, and the windows of the storage warehouse should be equipped with shading facilities.
Third, the choice of storage containers should not be underestimated. Be sure to choose corrosion-resistant containers, because hydrochloride salts are corrosive to a certain extent. Containers made of glass can be used, which have good chemical stability and are not easy to react with the substance; if using plastic containers, make sure that the plastic material will not be corroded or interact with it. At the same time, the container must be well sealed to prevent air, water vapor, etc. from entering.
Fourth, pay attention to the isolation from other substances. This substance should not be stored with strong oxidants, strong bases and other substances. Because it comes into contact with strong oxidants, it may cause violent oxidation reactions, which poses a safety hazard; when it encounters strong bases, chemical reactions may occur, resulting in material failure.
When storing ethyl-2-amino-5-chloro-1,3-thiazole-4-carboxylic acid hydrochloride, pay attention to temperature and humidity, light, storage containers and isolation from other substances, so as to ensure its quality and stability.

I look at the "ethyl+2-amino-5-chloro-1, 3-thiazole-4-carboxylate+hydrochloride" you are inquiring about. This is the English name of the chemical substance, which is translated as "2-amino-5-chloro-1,3-thiazole-4-carboxylate ethyl ester hydrochloride". As for its market price range, because "Tiangong Kaiwu" is an ancient scientific and technological work, it does not involve the price of this substance, so I will tell you the current situation.
The price of this chemical often varies due to many factors. First, purity is the key. If the purity is extremely high, it is suitable for high-end scientific research, pharmaceutical research and development and other fields, and its price is high; if the purity is slightly lower, it is mostly used in general industrial production, and the price is slightly cheaper. Second, the scale of production also has an impact. In large-scale production, due to the scale effect, the unit cost is reduced, and the price may be relatively low; in small-scale production, the cost is higher, and the price will increase. Third, the market supply and demand relationship cannot be ignored. If demand is strong and supply is limited, the price will rise; if supply exceeds demand, the price will decline.
Generally speaking, in the scientific research reagent market, the price of this compound with high purity may range from tens of yuan to hundreds of yuan per gram. In the industrial raw material market, depending on the batch size, the price per ton may range from tens of thousands to hundreds of thousands of yuan. However, this is only a rough range, the actual price may change from time to time, and the market changes. If you want to know the exact price, you need to consult the relevant chemical product suppliers or market survey agencies in detail.