Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Eh! This "Ethyl 2- (4 - hydroxyphenyl) -4 - methyl - 1,3 - thiazole - 5 - carboxylate" is also known as a compound. Its chemical group is based on thiazole group, which is a five-membered group containing sulfur and nitrogen, in which sulfur and nitrogen atoms are arranged.
In the second position of thiazole, there is a (4 - hydroxyphenyl) group. Above this phenyl group, there is a group at the fourth position, which is phenolic. In the fourth position of thiazole, there is a methyl group. In addition, the fifth position of thiazolyl has a carboxylic acid ethyl ester group, which is esterified from a carboxyl alcohol group.

, this compound is special, and the group, aryl group, alkyl group and ester group are combined in one group. Each group affects each other, giving it specific chemical activity. It may have important uses in fields such as synthesis and physicochemistry.

Ethyl 2- (4-hydroxyphenyl) -4-methyl-1, 3-thiazole-5-carboxylate (2 - (4-hydroxyphenyl) -4-methyl-1,3-thiazole-5-carboxylic acid ethyl ester) This substance has a wide range of uses and is often used as a key intermediate in the field of medicine. Because of its unique structure, it is indispensable in the synthesis of many drugs with specific pharmacological activities. For example, when developing drugs with antibacterial and anti-inflammatory effects, this is used as a starting material and can be obtained through a series of delicate chemical reactions. The thiazole ring and hydroxyphenyl group in its structure are of great significance for the interaction between the drug and a specific target, which can help the drug to accurately act on bacteria and achieve antibacterial and anti-inflammatory effects. < Br >
In the field of materials science, it also has important applications. It can be used to prepare functional polymer materials. Through clever chemical modification, it is connected to the polymer chain segment, giving the material special properties. For example, using its specific binding ability with certain substances, the material has the recognition and adsorption properties of specific molecules, and it is very useful in separating membrane materials. It can efficiently separate specific ingredient mixtures and improve the separation efficiency and selectivity of materials.
In the field of organic synthetic chemistry, as an important synthetic block, with its multi-activity check point, it can derive many complex and novel organic compounds. Chemists can perform functional group transformation, cyclization, and other reactions according to different synthesis strategies, expanding the structural diversity of organic compounds, providing rich materials for the creation and research of new substances, promoting the vigorous development of organic synthetic chemistry, and helping to explore more unknown chemical substances and properties.

The preparation of ethyl 2 - (4 -hydroxyphenyl) - 4 -methyl - 1,3 -thiazole - 5 -carboxylic acid esters is an important task in organic synthesis. The synthesis method follows several common paths.
First, it can be initiated by sulfur-containing compounds and carbonyl compounds. First, the sulfur-containing reagent reacts with a carbonyl derivative with a suitable substituent under specific conditions. For example, thiourea or thioamide-containing substances, and p-hydroxyacetophenone derivatives, in a suitable base-catalyzed and solvent system, are condensed to form the prototype of thiazole rings. In this process, the choice of base is very critical, such as potassium carbonate, sodium carbonate and other inorganic bases, or triethylamine and other organic bases, can be selected according to the specific situation of the reaction. Solvents such as ethanol and acetone are commonly used to promote the dissolution and reaction process of the reactants.
Second, halogenates can also be used as raw materials. P-hydroxyhalobenzene and 4-methyl-5-carboxythiazole derivatives are coupled to form carbon-carbon bonds in the presence of metal catalysts. Commonly used metal catalysts such as palladium catalysts, ligands such as triphenylphosphine, etc. The reaction needs to be carried out in an inert gas protective atmosphere to prevent catalyst deactivation and side reactions. The temperature, time and other conditions of this reaction need to be carefully regulated to achieve higher yield and selectivity.
Furthermore, there is a strategy that involves gradually constructing thiazole rings and introducing the required substituents. A simple thiazole carboxylate is first synthesized, and then 4-hydroxyphenyl is introduced through a selective substitution reaction. In this process, the activity and selectivity of each step of the reaction need to be considered, and the protective group strategy should be used to protect the sensitive group and avoid unnecessary side reactions.
Synthesis of ethyl 2 - (4 - hydroxyphenyl) - 4 - methyl - 1,3 - thiazole - 5 - carboxylic acid ester has various methods, each method has its own advantages and disadvantages, according to the actual situation, such as raw material availability, cost, target product purity and other factors, carefully select and optimize the reaction conditions to achieve the best environment.

Ethyl 2- (4 - hydroxyphenyl) -4 - methyl - 1,3 - thiazole - 5 - carboxylate (2 - (4 - hydroxyphenyl) - 4 - methyl - 1,3 - thiazole - 5 - carboxylate), this physical property is particularly important.
Looking at its physical properties, it is often solid at room temperature, which is due to strong intermolecular forces. Its melting point is a specific temperature, about [specific melting point value]. At this temperature, the substance changes from solid to liquid. The determination of this melting point is extremely beneficial to identify its purity and characteristics. Its color is usually white to off-white, and this pure color can help to detect its purity.
As for solubility, it has a certain solubility in organic solvents such as ethanol and acetone. Because its molecular structure contains organophilic groups, it can form specific forces with organic solvent molecules, such as van der Waals force, hydrogen bond, etc. However, in water, the solubility is very small, because water is a highly polar solvent, and the overall polarity of the substance is not very high, and the force between water molecules is weak.
In addition to its chemical properties, the hydroxyl groups contained in the molecule have active chemical activity and can participate in many reactions, such as esterification reactions, and the hydrogen of the hydroxyl group can be replaced by other groups. The thiazole ring structure also gives unique chemical properties. The presence of nitrogen and sulfur atoms on the ring gives the ring a certain electron cloud density distribution, which can react with electrophilic or nucleophilic reagents. The ester-based part can undergo hydrolysis reaction under the catalysis of acid or base. This hydrolysis reaction is of great significance in the study of organic synthesis and drug metabolism pathways.
The physical and chemical properties of this compound are related to each other and affect its application in many fields, such as drug research and development, organic synthesis, etc. The clarity of its properties lays the foundation for subsequent research and application.

Alas! You ask "Ethyl 2- (4-hydroxyphenyl) -4-methyl-1, 3-thiazole-5-carboxylate" in the price range of the market, this is not an easy question to answer. The price of this product often changes due to many reasons.
First, the purity of the product is the key. If the purity is high, it is suitable for high-end scientific research or pharmaceutical manufacturing, and its price is high; if the purity is slightly lower, it is mostly used for general experimental or industrial purposes, and the price is low.
Second, the state of supply and demand also affects its price. If there are many people in the market, and there are few people in supply, the price will rise; if the supply exceeds the demand, the price will decline.
Third, the place of origin and the channel are different, and the price is also different. Those produced by well-known large factories have high or high prices because of their reliable quality; while those produced by small factories have low prices because of their low cost.
However, in my opinion, the price per gram of high-purity products for scientific research may reach hundreds or even thousands of yuan; if it is used for industrial use, the price per kilogram may be between thousands and 10,000 yuan for those with slightly lower purity. But this is only speculation, and the market situation is fickle. The actual price needs to be consulted with chemical raw material suppliers, reagent sellers, etc., to be sure.