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What is the chemical structure of Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate?
Ethyl 2- (3 - formyl - 4 - isobutoxyphenyl) -4 - methyl - 5 - Thiazolecarboxylate, its chemical structure is as follows. This compound contains a thiazole ring, with a substituent of 2- (3 - formyl - 4 - isobutoxyphenyl) in the second position, a methyl in the fourth position, and a carboxylic acid ethyl ester in the fifth position.
The thiazole ring is a five-membered heterocycle composed of sulfur atom, nitrogen atom and three carbon atoms, which has certain aromatic properties. Among the substituents at the 2-position, the 3-position of the benzene ring has a formyl group (-CHO), and the 4-position is connected to an isobutoxy group (-O-CH -2 -CH (CH < Br >). The existence of this formyl group and the isobutoxy group makes the benzene ring have specific electronic effects and spatial effects. In the isobutoxy group, the oxygen atom is connected to the benzene ring, and its lone pair electrons produce a electron-donating conjugation effect to the benzene ring. At the same time, the presence of alkyl groups has a donor electron induction effect, while the formyl group is an electron-withdrawing group, which has an electron-withdrawing conjugation effect and induction effect.
Furthermore, the methyl group at the 4-position of the thiazole ring has a certain influence on the electron cloud distribution of the thiazole The presence of the carbonyl group of the 5-position carboxylic acid ethyl ester (-COOCH < unk > CH < unk >) gives the molecule a certain polarity, and the structural characteristics of the ester group affect the reactivity and physical properties of the molecule. The overall chemical structure of this compound determines that it may exhibit specific reactivity and biological activity in the fields of organic synthesis, medicinal chemistry, etc.
What are the main uses of Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate?
Ethyl 2- (3 - formyl - 4 - isobutoxyphenyl) -4 - methyl - 5 - Thiazolecarboxylate is an organic compound. Its main use involves the field of pharmaceutical chemistry and organic synthesis.
In medicinal chemistry, such compounds are often potential pharmaceutical intermediates. Because of the specific functional groups contained in its structure, such as aldehyde (-CHO), isobutoxy (-O-CH ² CH (CH
)) and thiazole ring, it has unique chemical properties and biological activities. After reasonable chemical modification and derivatization, drug molecules with specific pharmacological activities, such as antibacterial, anti-inflammatory, and anti-tumor effects, can be obtained.
In the field of organic synthesis, this compound can be used as a key starting material or intermediate to construct more complex organic molecular structures. Through various organic reactions, such as the condensation reaction of aldehyde groups and the nucleophilic substitution reaction of thiazole rings, the diversification of molecules can be realized, and then a series of organic compounds with novel structures can be synthesized, providing a material basis for the research and development of new materials and the preparation of fine chemicals.
In conclusion, Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate has important application value in medicine and organic synthesis, providing key material support for the research and development of related fields.
What are the synthesis methods of Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate?
The synthesis method of Ethyl 2- (3 - formyl - 4 - isobutoxyphenyl) -4 - methyl - 5 - Thiazolecarboxylate is not directly mentioned in the ancient book "Tiangong Kaiwu", but it can be traced from the wisdom of the ancients and related chemical process principles.
To synthesize this product, you can first look at the method of ancient people's synthesis, often based on natural things, step by step, to achieve what you want. As far as raw materials are concerned, when looking for things containing corresponding groups. If you want to get 3 - formyl - 4 - isobutoxyphenyl part, or you can find those containing benzene ring and easy to introduce formyl and isobutoxy groups. In chemical synthesis, the ancients made good use of natural products through multiple treatments, such as extracting benzene-containing substances from specific plants, and purifying them by distillation and extraction to obtain pure substrates.
The construction of thiazole rings can be used for reference in the synthesis of heterocycles of the ancients. Often raw materials containing sulfur and nitrogen are condensed under specific conditions. Ancient chemistry, although there is no accurate instrument today, but with experience and practice, the balance of temperature, time and material ratio can be found. For example, organic sulfur and nitrogen-containing reagents are used in pottery kettles, and carbon fire is used to slow down the temperature, and the time is properly controlled to promote the formation of rings.
The introduction of ester groups can refer to the method of esterification of the ancients. In this compound, the corresponding carboxylic acid and ethanol are stirred according to the ancient temperature control method to form the ester group on the molecule.
Although there is no accurate synthesis of this compound in ancient books, according to the spirit of "Tiangong Kaiwu", taking nature as the source and experience as the guide, making good use of ancient methods and ingenious design, or a good synthesis method of Ethyl 2- (3 - formyl - 4 - isobutoxyphenyl) -4 - methyl - 5 - Thiazolecarboxylate can be obtained.
What are the physicochemical properties of Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate?
Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-thiazolecarboxylate is an organic compound. Its physical and chemical properties are unique and have attracted much attention in the fields of chemical industry and medicine.
Looking at its physical properties, at room temperature and pressure, this substance may be a solid, but the exact physical form needs to be determined by experiments. Properties such as melting point and boiling point are of great significance for its purification and application. Generally speaking, the melting point of organic compounds containing such structures is within a certain range due to intermolecular forces. There are interactions such as van der Waals forces and hydrogen bonds between molecules, which affect their melting points. If the molecular structure is regular and the interaction is strong, the melting point is higher; otherwise, it is lower.
The boiling point is also affected by intermolecular forces and molecular weight. The higher the molecular weight, the stronger the intermolecular force, and the higher the boiling point. In addition, its solubility is also an important physical property. The compound contains polar groups such as ester groups and aldehyde groups, and may have certain solubility in polar organic solvents such as ethanol and acetone. However, due to the large non-polar part in the molecule, its solubility in water may be poor.
As for chemical properties, ester groups can undergo hydrolysis reactions. Under acidic or alkaline conditions, the corresponding carboxylic acids and alcohols are hydrolyzed. The aldehyde group has strong reductive properties and can react with various oxidants, such as reacting with Torun reagent to form a silver mirror, and reacting with Feilin reagent to form a brick-red precipitate. In addition, the thiazole ring also has certain chemical activity, which can participate in various nucleophilic and electrophilic substitution reactions, providing many possibilities for organic synthesis.
The physicochemical properties of this compound lay the foundation for its application in different fields. However, in order to accurately grasp its properties, rigorous experimental investigation and analysis are still required.
What is the price range of Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate in the market?
I don't know the price range of "Ethyl 2- (3-formyl-4-isobutoxyphenyl) -4-methyl-5-Thiazolecarboxylate" in the market. This compound may be a special material in the field of fine chemicals or pharmaceuticals, and its price often varies due to factors such as purity, output, supply and demand, and market fluctuations. To know its price, you can consult chemical raw material suppliers, chemical trading platforms, or relevant industry experts. However, the market price may change rapidly, and it is difficult to determine the exact price range. You can also check past transaction records, industry reports, or there are clues to follow, but it may be difficult to be accurate. In short, if you want to get this compound price range, you need to explore it many times and combine it with the current market conditions.