ATHIAA (Z)-2-(2-Aminothiazole-4-yl)-2-Hydroxyimino Acetic Acid

2 - (2 -Aminothiazole-4-yl) - 2 -hydroxyiminoacetic acid, this is an organic compound. Its chemical structure is cleverly spliced from several parts.
The thiazole ring is a five-membered heterocyclic ring containing sulfur and nitrogen, which is common in many drugs and bioactive molecules. In this product, the thiazole ring is connected to the amino group at the 2nd position. This amino group gives the compound specific basicity and reactivity, and can participate in various chemical reactions, such as salting with acids or substituting with electrophilic reagents.
The 4th position of the thiazole ring is connected to the key structure, that is, the 2-hydroxyiminoacetic acid part. Among them, the imino group (= N-OH) is a nitrogen-containing double bond structure, which has both nucleophilic and electrophilic properties. Because the nitrogen atom has lone pairs of electrons, the electronegativity of the oxygen atom highly causes the electron cloud to bias towards oxygen, so that the imino group has unique reactivity.
The acetic acid group connected to the imino group introduces a carboxyl group (-COOH) to the compound. The carboxyl group is acidic and can ionize hydrogen ions. It can react with bases to form salts and can also participate in esterification and other reactions, which has a great impact on the physical and chemical properties of the compound, such as solubility and acidity. Overall, the chemical structure of 2- (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid fuses a variety of active groups, and each part synergistically endows the compound with rich chemical properties and potential biological activities, which may have important applications in the fields of organic synthesis and medicinal chemistry.

(2-Aminothiazole-4-yl) -2-hydroxyiminoacetic acid, often referred to as 2-aminothiazole-4-glyoxyaldoxime, is widely used.
In the field of medicine, it can be used as a key intermediate. It is found in the synthesis of many antibacterial and antiviral drugs. Due to its specific chemical structure, it can cleverly react with other compounds to construct a molecular structure with biological activity. Taking a new type of antibacterial drug as an example, with the help of its condensation with specific nitrogen-containing heterocyclic compounds, it can generate substances that exhibit strong inhibitory activity against specific pathogens, providing a powerful weapon for humans to resist the invasion of pathogens.
In the creation of pesticides, (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid also plays an important role. By reacting with different substituents, a variety of pesticide varieties can be created. After some pesticides are synthesized, they have high-efficiency contact and stomach toxicity effects on pests, and are relatively friendly to the environment. For example, a new type of insecticide, after using this compound, has a high killing rate on common agricultural pests, and degrades quickly in the natural environment, reducing the lasting impact on the ecological environment, effectively ensuring the robust growth of crops and improving agricultural output.
In the field of organic synthetic chemistry, it is an extremely useful synthetic building block. Because it contains a variety of active functional groups, it can participate in various complex organic reactions. It can undergo condensation reactions with aldodes, ketones and other compounds to construct complex heterocyclic compounds. These heterocyclic compounds have potential application value in materials science, fine chemistry and other fields. For example, when preparing some high-performance polymer materials, the introduction of the heterocyclic structure synthesized by this can significantly improve the thermal stability and mechanical properties of the materials, expand the application scenarios of materials, and promote the innovation and development of related industrial technologies.

The method of preparing (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid (ATHIAA) is a delicate chemical preparation. The method is as follows:
First take appropriate starting materials, one of the key raw materials is a thiazole compound with a specific structure, containing amino groups in the 2 position. This raw material needs to be carefully selected and pretreated to ensure that its purity and activity are suitable for this reaction.
The thiazole raw material is placed in a suitable reaction vessel, and an appropriate amount of solvent is added. The solvent needs to be able to dissolve the raw material well and have no adverse effect on the subsequent reaction. Then, slowly add the reagent containing hydroxyimino group, and the addition process needs to strictly control the rate and temperature. Temperature control is extremely important, and it is often necessary to maintain a specific range, such as a low temperature range, to prevent the occurrence of side reactions.
During the reaction process, close monitoring is required, and means such as thin-layer chromatography are often used to detect the consumption of raw materials and the formation of products. When the reaction reaches the expected level, that is, the conversion of raw materials and the purity of products are both at observable levels, follow-up treatment is carried out.
The reaction mixture is first separated, and the extraction method is often used. A suitable extractant is selected to separate the target product from the reaction system. Subsequently, the extracted product solution is purified, or column chromatography is used to remove impurities to obtain a relatively pure (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid.
The whole preparation process requires fine operation in each step, and precise control of raw materials, reagents, temperature, time and many other factors is required to obtain high-quality products.

(2-Aminothiazole-4-yl) -2-hydroxyiminoacetic acid, often represented by its English abbreviation ATHIAA (Z). The properties of this substance are quite important and related to its application in many fields.
Looking at its physical properties, under normal temperature and pressure, (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid is mostly white to light yellow crystalline powder. This form makes it easy to store and transport, and it is convenient for subsequent processing operations. The powder has fine texture and good fluidity, and can be well mixed with other substances in some powder processing processes. It has a certain solubility in water, which makes it more convenient in the reaction or application of aqueous solution systems. For example, in some liquid-phase chemical reactions, it can be uniformly dispersed in the system as a reactant or intermediate. However, its solubility in organic solvents varies depending on the type of solvent. It has relatively high solubility in polar organic solvents such as methanol and ethanol, while it has little solubility in non-polar solvents such as n-hexane and benzene.
When it comes to chemical properties, (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid has multiple active functional groups such as amino, carboxyl, thiazole ring and hydroxyimino group. Amino groups are basic and can be neutralized with acids to form corresponding salts. This reaction is often used in adjusting their pH and preparing specific derivatives. The presence of carboxyl groups endows them with acidity, which can participate in esterification reactions and form esters with alcohols under the action of catalysts, which can be used to construct compounds with specific structures and functions in organic synthesis. The thiazole ring imparts certain stability and special electronic effects to the molecule, which affects the reactivity and selectivity of the whole molecule. Hydroxyimino groups can undergo reactions such as oximization, which is often used as an important reaction check point in the field of organic synthesis to introduce specific structures and expand the chemical diversity of molecules. The interaction and synergy of these functional groups determine the rich chemical reactivity and wide application prospects of (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid.

Nowadays, there is (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid, which is commonly used in the market, and I will describe it in detail.
This (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid is widely used in the chemical and pharmaceutical fields. Its common specifications are mostly based on content. Common in the market, there is a specification of 98% content. This high content is very critical in the synthesis of fine chemicals, such as the preparation of specific drug intermediates, because its high purity can ensure the accuracy and efficiency of the reaction and reduce the disturbance of side reactions.
Also has a 95% content specification. Although the content is slightly lower than that of 98%, some industrial processes that require a little less purity, such as the preliminary synthesis of some common pharmaceutical raw materials, are also competent and cost-effective.
In addition to the content specifications, the packaging specifications are also diverse. Common ones are measured in kilograms, such as 1kg packs, which are mostly required for laboratory research and development or a small amount of trial production. It is convenient to use and conducive to precise control of experiments. 5kg packs are also not uncommon, suitable for small and medium-sized production pre-research or specific small batch orders.
Larger packaging specifications, such as 25kg packs, are more common in large-scale industrial production and procurement, which can meet the material requirements of mass production, and has considerable advantages in transportation and storage costs.
There are also special specifications customized according to customers, or fine-tuned in content, or ingenious packaging shapes to meet the needs of diverse markets. These are the common specifications and forms of (2-aminothiazole-4-yl) -2-hydroxyiminoacetic acid in the market, each has its own uses to meet the needs of different industries and different stages.