What is the chemical structure of (6R, 7R) -7- [[ (2Z) - (2-amino-4-thiazolyl) (methoxyimino) acetyl] amino] -3- [ (Z) -2- (4-methylthiazole-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid?

(6R, 7R) -7- [[ (2Z) - (2-hydroxy-4-pyridyl) (methoxyimino) acetyl] amino] -3- [ (Z) -2- (4-methylpyridin-5-yl) furyl] -3-cephalosporene-4-carboxylic acid, this is the chemical name of a specific compound. The following describes its chemical structure in the classical Chinese form of "Tiangongkai".

Looking at this compound, its core structure is the cephalosporene parent nucleus. At the 7th position of the parent nucleus, there is a complex side chain connected. This side chain starts as [ (2Z) - (2-hydroxy-4-pyridyl) (methoxyimino) acetyl] amino, which is like a leaf on a branch. Among them, (2Z) indicates a specific configuration, and 2-hydroxy-4-pyridyl is cleverly connected to methoxyiminoacetyl to form a unique structural unit.

Then look at the third position of the parent nucleus, followed by [ (Z) -2- (4-methylpyridine-5-yl) furanyl], this furanyl group is like a delicate accessory, and 4-methylpyridine-5-yl adds unique properties to it, and (Z) also determines its configuration.

And the carboxyl group at the 4th position is the finishing touch, giving the whole compound a specific chemical activity. Overall, the structure of each part is closely interlocked, like a carefully constructed pavilion, and every detail affects the properties and functions of the compound, showing the exquisite chemical structure.

What are the main pharmacological effects of (6R, 7R) -7- [[ (2Z) - (2-amino-4-thiazolyl) (methoxyimino) acetyl] amino] -3- [ (Z) -2- (4-methylthiazole-5-yl) vinyl] -3-cephalosporin-4-carboxylic acid?

(6R, 7R) -7- [[ (2Z) - (2-hydroxy-4-pyridyl) (methoxyimino) acetyl] amino] -3- [ (Z) -2- (4-methylpyridine-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid, which is an important component of cephalosporin antibiotics. Its main pharmacological effects are as follows:
First, it can inhibit the synthesis of bacterial cell walls. Bacterial cell walls are essential for maintaining bacterial morphology and stability. The substance can bind to the key penicillin-binding protein in the bacterial cell wall synthesis process, inhibit transpeptidase activity, hinder peptidoglycan cross-linking, and block cell wall synthesis. The bacteria cannot maintain normal morphology and osmotic pressure, and eventually rupture and die.
Secondly, it has broad-spectrum antibacterial activity. It has good antibacterial effect on many Gram-positive and Gram-negative bacteria. For example, common Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, as well as Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, are all within its scope of action and can effectively treat various infections caused by these bacteria.
Furthermore, it has strong penetrating ability. It can quickly penetrate the outer membrane of bacteria, reach the target, quickly exert antibacterial effect, improve treatment efficiency, and help patients recover as soon as possible.
In addition, it also has a relatively low induction rate of drug resistance. Compared with some other antibiotics, the probability of inducing bacterial resistance during use is low, which alleviates the problem of antibiotic resistance to a certain extent and provides a reliable choice for clinical anti-infective treatment.

(6R, 7R) -7- [[ (2Z) - (2-Amino-4-thiazolyl) (methoxyimino) acetyl] amino] -3- [ (Z) 2- (4-methylthiazole-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid What are the precautions in clinical application?

(6R, 7R) -7- [[ (2Z) - (2-hydroxy-4-pyridyl) (methoxyimino) acetyl] amino] -3- [ (Z) -2- (4-methylpyridine-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid should pay attention to the following things in clinical application:
First, pay attention to drug interactions. When this drug is used in combination with other drugs, it may cause interactions, affect the efficacy or increase the risk of adverse reactions. If used with probenzosul, it will slow down the excretion of the drug and increase the blood concentration. Although it may increase the antibacterial effect, it may also increase the chance of adverse reactions. Before taking the drug, be sure to inform the doctor of other drugs being used, including prescription drugs, over-the-counter drugs, health products, etc., to help the doctor evaluate potential interactions.
Second, pay attention to allergic reactions. Some people are allergic to this drug, and the allergic manifestations may be rash, itching, breathing difficulties, and even anaphylactic shock. Those who have been allergic to cephalosporins and penicillin drugs in the past have a higher risk of allergies. During the medication period, if allergic symptoms occur, they should immediately stop the drug and seek medical attention.
Third, pay attention to the use of drugs for special groups. Pregnant women and breastfeeding women need to weigh the pros and cons of taking drugs. The drug may pass through the placenta or be secreted into milk, and has potential effects on the fetus or baby. The elderly and children, because of their physiological functions are different from adults, the dosage and course of treatment may need to be adjusted, and they must strictly follow the doctor's advice.
Fourth, follow the correct medication method. Take the medicine on time and according to the doctor's instructions. Do not increase or decrease the dose or stop the medicine by yourself. If you miss it, take it as soon as possible, but do not double the dose until the next time you take the medicine, so as not to increase adverse reactions. Oral dosage forms can be taken before or after meals. If there is gastrointestinal discomfort, it is advisable to take it after meals.
Fifth, pay attention to adverse reactions. Common adverse reactions include gastrointestinal reactions, such as nausea, vomiting, and diarrhea; there may also be blood system reactions, such as leukopenia and thrombocytopenia; there may also be abnormal liver function, such as elevated transamin During the medication period, if any abnormal symptoms appear, such as persistent diarrhea, fever, fatigue, etc., the doctor should be promptly informed.

What are the synthesis methods of (6R, 7R) -7- [[ (2Z) - (2-amino-4-thiazolyl) (methoxyimino) acetyl] amino] -3- [ (Z) 2- (4-methylthiazole-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid?

To prepare (6R, 7R) -7- [ (2Z) - (2-hydroxy-4-pyridyl) (methoxyimino) acetyl] amino] -3- [ (Z) -2- (4-methylpyridyl-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid, the method is as follows:

Take appropriate raw materials first, and proceed with various reactions in sequence. The desired structure can be constructed by organic synthesis from the starting material through delicate steps. < Br >
or first through a specific reaction to convert the relevant group, such as the use of acylation reaction, the (2-hydroxy-4-pyridyl) (methoxyimino) acetyl group is introduced to a specific position to obtain the key intermediate. This process requires attention to the precise control of the reaction conditions, such as temperature, pH, etc., so that the reaction proceeds in the desired direction.

Then, the 3-position side chain is constructed. Through a suitable reaction, (Z) -2- (4-methylpyridine-5-yl) vinyl is introduced. This step also requires the selection of suitable reagents and conditions to ensure the selectivity and yield of the reaction.

Or other synthesis strategies can be used to build a partial frame first, and then gradually splice it. By rationally designing the reaction sequence, unnecessary side reactions can be avoided.

After the reaction is completed, the impurities are removed by separation and purification to obtain a pure target product. Column chromatography, recrystallization and other means can be used to improve the purity of the product to achieve the required standard. In this way, this compound can be prepared.

Does (6R, 7R) -7- [[ (2Z) - (2-Amino-4-thiazolyl) (methoxyimino) acetyl] amino] -3- [ (Z) 2- (4-methylthiazole-5-yl) vinyl] -3-cephalosporene-4-carboxylic acid interact with other drugs?

I look at what you said, it seems to be a description of complicated medicinal ingredients. However, such chemical symbols and terms did not exist in ancient times. Although I do not understand the wonders of chemistry here, it is common sense that all medicines in the world may interact with each other.

In the past, the medicine was mostly based on the classics of Materia Medica and other ancient books, and was compatible with natural medicinal materials. Between medicinal materials, or mutual growth and mutual restraint, and mutual use. For example, ginseng with Schisandra, which can increase the power of replenishing qi, this is the beard; licorice blends all medicines to prevent the medicine from injuring the right, this is the effect. There are also the commandments of eighteen opposites and nineteen fears, half summer is anti-aconite, and ginseng fears the five spirit oils. If used improperly, it will not be a disaster.

As for what you said (6R, 7R) -7- [ (2Z) - (2-hydroxy-4-pyridyl) (methoxylamino) ethyl] hydroxy] -3- [ (Z) -2- (4-methylpyridine-5-yl) vinyl] - 3-cephalosporene-4-carboxylic acid and other drugs, although I don't know the details, but the drug interaction is related to human life and should not be careless. When a doctor uses medication, he should carefully check the classics and collect many prescriptions, and he must refer to the experience of his predecessors, combine the patient's condition, and weigh the pros and cons before he can use it. Therefore, in my opinion, such drugs must be carefully explored to consider whether there is an interaction, and must not be ignored.