(6R)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

The chemical structure of (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran is an interesting topic in the field of organic chemistry. The structural characteristics of this compound contain unique spatial configuration and functional group combination.
Its naming " (6R) " reveals the three-dimensional configuration of the compound at carbon 6 atom, following the R and S configuration calibration rules of stereochemistry in organic chemistry, indicating the spatial arrangement of atoms or groups at this position. "2,6-dihydroxy" indicates that there are hydroxyl (-OH) functional groups attached to carbon 2 and 6 atoms, respectively. Hydroxyl groups, as an important polar functional group, endow the compound with certain hydrophilicity and chemical reactivity, and can participate in various chemical reactions such as esterification and oxidation.
"4,5,6,7-tetrahydro" means that the part of the benzofuran ring in the benzofuran ring system is not a completely conjugated aromatic structure, but undergoes a hydrogenation process at carbon atoms 4, 5, 6, and 7, forming a partially saturated state. This partially saturated structure changes the original electron cloud distribution and stability of the benzofuran ring, which in turn affects the physical and chemical properties of the whole molecule.
The benzofuran ring, as the core framework of the compound, is formed by fusing a benzofuran ring with a furan ring. This fused structure endows the molecule with unique planarity and rigidity, which has an important impact on its recognition, binding and selectivity in chemical reactions in vivo.
Overall, the chemical structure of (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran is composed of a specific stereoconfiguration, characteristic functional groups and partially saturated fused ring system. The interaction of these structural elements determines the unique properties and potential applications of the compound.

The main uses of (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran are quite extensive.
In the field of medicine, it can be used as a key intermediate to synthesize many biologically active drugs. Due to its unique chemical structure, it can participate in specific chemical reactions and help build complex drug molecular structures. For example, in the synthesis of drugs for the treatment of certain neurological diseases, it can be integrated into drug molecules through specific reaction steps by virtue of its hydroxyl and hydrogen structures, giving drugs precise pharmacological activities, such as regulating neurotransmitter transmission and repairing damaged nerve cells.
In the field of materials science, it can be used to prepare materials with special properties. The benzofuran ring and hydroxyl group in its structure can make it copolymerize with other compounds. Like polymerization with conductive polymer monomers, the resulting new materials may have both good electrical and mechanical properties, and become popular in electronic devices such as flexible display screens and conductive components of wearable devices.
In organic synthesis chemistry, it is an extremely important synthetic building block. With its various activity check points, chemists can use various organic reactions to modify and derive its structure. For example, through halogenation reactions, alkylation reactions, etc., different substituents are introduced into their molecules, resulting in the preparation of a series of organic compounds with different structures, which expands new directions for the study of organic synthetic chemistry and promotes the creation of new organic materials and compounds.

There are many synthetic methods of (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran, which are described in detail below.
First, simple phenolic compounds can be started. First, a halogen atom is introduced at the phenolic hydroxyl ortho-site through a halogenation reaction with a suitable phenol, and then condensed with a compound containing active methylene under basic conditions to construct the basic skeleton of the furan ring. Next, the unsaturated bond is reduced with a suitable reducing agent to achieve the tetrahydrobenzofuran structure. Finally, the hydroxyl group is precisely introduced by means of oxidation or hydrolysis to obtain the target product. The raw materials for this route are easy to obtain, but the reaction steps are slightly complicated, and the control of the reaction conditions is strict. Fine regulation is required to ensure the yield and selectivity of each step.
Second, using catechol derivatives as starting materials is also a good strategy. Catechol and appropriate halogenated alcohols undergo nucleophilic substitution under base catalysis to form ether bonds. After that, the furan ring is constructed by means of intramolecular cyclization, and then the product is obtained through reduction, hydroxylation and other steps. This method route is relatively direct, but the selection and preparation of starting materials need careful consideration, and the acquisition of some catechol derivatives may be difficult.
Third, semi-synthesis using natural products as raw materials. Some natural products with similar structures can be used as starting points and gradually converted into target products through chemical modification. The advantage of this approach is that the starting materials have a certain structural similarity, some reaction steps may be simplified, and the source of natural products is relatively green and sustainable. However, the extraction and separation of natural products is often quite challenging, and subsequent structural modifications also require fine control of reaction conditions.
All this synthesis method requires chemists to carefully weigh the choices and carefully optimize the reaction conditions according to their actual conditions, such as the availability of raw materials, reaction equipment, and technical level, in order to obtain (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran efficiently.

(6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran, which has many physical and chemical properties. Its properties may be crystalline powder, stable at room temperature, and will change under specific conditions.
In terms of physical properties, it has a certain melting point and is located in a certain temperature range by measurement, which can help to identify and judge the purity. Its solubility is special, and it has different solubility in organic solvents such as ethanol and acetone, and dissolves very little in water. This property is of great significance in extraction, separation and preparation.
Chemical properties, due to the presence of hydroxyl groups, it has certain acidity and can react with bases to form salts. Hydroxyl groups can participate in esterification reactions and react with organic acids in catalysts to form ester compounds. Its benzofuran structure is aromatic and can undergo electrophilic substitution reactions, such as halogenation and nitrification. The reaction check point and conditions vary depending on the structure. At the same time, the tetrahydrobenzofuran part has certain reductivity, and will react with specific oxidants to cause structural changes.
The physical and chemical properties of this compound are widely used in the fields of medicinal chemistry and organic synthesis. Drug development can use its interaction characteristics with biomolecules to synthesize drugs with specific biological activities; as a key intermediate in organic synthesis, it can use its reaction characteristics to construct complex organic molecular structures.

The price range of (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran in the market is difficult to determine. The price of this material depends on many reasons.
First, the difficulty of its preparation is one of the main reasons. If the preparation method is complicated, many steps are required, and the yield of each step is not high, or rare raw materials, special reagents and equipment are required, the cost will increase, and the price will also increase. If the preparation is made, extremely pure starting materials are required, and the purification of this material is not easy, resulting in higher costs.
Second, the supply and demand of the market are also heavy. If this (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran is in high demand in pharmaceutical research and development, chemical synthesis and other fields, but the supply is limited, according to the reason of supply and demand, its price should rise. On the contrary, if there is little demand and oversupply, the price may drop.
Furthermore, the scale of production also has an impact. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price may also drop. However, small-scale production, the unit cost is higher, and the price is difficult to lower.
Also, the difference in region is also related to its price. Different places have different prices due to differences in raw material costs, labor costs, and transportation costs. In prosperous places, the cost is high, and the price may be high; in remote places, the cost is low, and the price may be different.
In summary, in order to determine the price range of (6R) -2,6-dihydroxy-4,5,6,7-tetrahydrobenzofuran, it is necessary to carefully observe the preparation, supply and demand, scale, region and other factors before we can have a more accurate theory. Today, it is difficult to know the exact price range based on the information given.