6-Methoxy-1,3-benzothiazole-2-carboxylic acid

6-Methoxy-1,3-benzothiazole-2-carboxylic acid, this is an organic compound. Looking at its structure, it is composed of benzothiazole ring and methoxy group and carboxyl group.
Its physical properties are mostly solid at room temperature, but the exact melting point and boiling point vary depending on purity and test conditions. Its solubility may have a certain solubility in organic solvents, such as common ethanol, dichloromethane, etc. However, its solubility in water may be limited, due to the difference between its molecular polarity and that of water.
Chemical properties, carboxylic groups are acidic and can neutralize with bases to form corresponding carboxylate. In case of alcohols, under suitable catalytic conditions, esterification reactions can occur to form ester compounds. The methoxy group is relatively stable, but under specific strong reaction conditions, substitution reactions may occur. Benzothiazole rings can participate in many common reactions of aromatic compounds, such as electrophilic substitution reactions, etc. The reaction check point may be affected by the positioning effect of methoxy and carboxyl groups. This compound may have potential applications in the field of organic synthesis and can be used as an intermediate to construct more complex organic molecular structures through a series of reactions.

6-Methoxy-1,3-benzothiazole-2-carboxylic acid, this substance has a wide range of uses. In the field of medicine, it is often used as a key intermediate to synthesize various drugs with specific biological activities. The structural properties of benzothiazole and methoxy can endow drugs with unique pharmacological properties, such as antibacterial, anti-inflammatory, and anti-tumor effects. For example, in the development of some new antibacterial drugs, this compound plays an important role. It can interfere with bacterial physiological processes through specific mechanisms of action and achieve antibacterial purposes.
In the field of pesticides, it also has important uses. It can prepare high-efficiency and low-toxicity pesticides, showing good control effects against some crop diseases and insect pests. For example, for some common plant pathogens, it can inhibit their growth and reproduction, protect the healthy growth of crops, and have little impact on the environment, which is in line with the current needs of green agriculture development.
In the field of materials science, 6-methoxy-1,3-benzothiazole-2-carboxylic acid can participate in the synthesis of functional materials. Due to its special chemical structure, the material can have unique optical and electrical properties through specific reactions. For example, it is used in the synthesis of certain photoelectric materials, and is applied to devices such as organic Light Emitting Diode (OLED) to improve its luminous efficiency and stability.
In addition, in the dye industry, it may also be used as a raw material for the synthesis of special dyes. With its structural modification, dyes with good dyeing properties and color fastness can be developed for dyeing processes in textile, leather and other industries. In short, 6-methoxy-1,3-benzothiazole-2-carboxylic acid has important application value in many fields and is of great significance to promote the development of related industries.

To prepare 6-methoxy-1,3-benzothiazole-2-carboxylic acid, the following method can be followed.
First take the appropriate starting material, take 2-amino-5-methoxythiophenol and oxaloyl chloride monoethyl ester as the starting reactant. Place 2-amino-5-methoxythiophenol in a suitable reaction vessel, add an appropriate amount of organic solvent, such as dichloromethane, etc., to help the reactants dissolve and mix uniformly. This organic solvent needs to be stable in nature and does not side-react with the reactants. Then under low temperature conditions, slowly add oxalyl chloride monoethyl ester dropwise. Low temperature can make the reaction proceed smoothly and reduce the occurrence of side reactions. The dropwise addition process requires constant stirring to ensure that the reactants are fully contacted.
After the dropwise addition is completed, gradually heat up to a suitable reaction temperature. This reaction temperature is determined according to the specific conditions of the experiment, generally between room temperature and 50 ° C. Keep this temperature and continue the reaction for several hours. During this period, the reaction progress can be monitored regularly. TLC and other means can be used. When the reaction reaches the desired level, stop the reaction.
Then proceed to the post-treatment step. The reaction solution is first washed with an appropriate amount of dilute alkali solution to remove the unreacted oxalyl chloride monoethyl ester and its by-products. The dilute alkali solution such as sodium b Separate the liquid, collect the organic phase, and dry it with a desiccant such as anhydrous sodium sulfate to remove the moisture in the organic phase. After that, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
For further purification of the crude product, column chromatography is appropriate. Select a suitable silica gel as the stationary phase, and use a solution of petroleum ether and ethyl acetate mixed in a certain proportion as the mobile phase. The distillate containing the target product is separated by column chromatography. After the solvent is evaporated, a pure 6-methoxy-1,3-benzothiazole-2-carboxylic acid can be obtained.
Throughout the synthesis process, attention should be paid to the precise control of reaction conditions, the accurate measurement of raw materials and reagents, and the operation specifications of each step, so that high yield and purity products can be obtained.

I have not obtained the exact price of 6 - Methoxy - 1,3 - benzothiazole - 2 - carboxylic acid in the market. However, the price of various chemical products in the market often changes due to various reasons. First, the source of production is different, and the price is different. If the product is abundant and easy to obtain, the price may be cheap; if it is difficult to obtain, it must be made by means of multiplication, and the price must be high. Second, the amount of use required also affects it. If the time is wide, and there are many people who want it, the price may rise; if the amount is rare, the price may fall. Third, the quality is good or bad, and the price is also different. The quality is always higher than the quality. Moreover, the supply and demand of the market, the circulation of time, and the cost of transportation are all related to the price. Therefore, if you want to know the exact price of this item, you should consult the chemical dealer, explore the platform of chemical trading, or visit the human performers of virtual idols in the industry to get a near-real price.

6-Methoxy-1,3-benzothiazole-2-carboxylic acid is a key compound in the field of organic synthesis, which is widely used in various industries such as medicine, pesticides and materials. To study the manufacturers that produce this compound, it is necessary to visit the chemical industry data of ancient and modern times.
In the past, when the chemical industry was first emerging, such compounds were mostly prepared by traditional chemical synthesis methods. At that time, many small-scale chemical workshops may have been involved in its production. However, at that time, the process was crude, and the yield and purity were difficult to meet today's standards.
With the evolution of the times, chemical technology is changing with each passing day. Today, many large-scale professional chemical companies have invested in the production of 6-methoxy-1,3-benzothiazole-2-carboxylic acid. In China, there are a number of companies focusing on fine chemicals, which have emerged in the field of compound production with advanced synthesis technology and strict quality control. Its efficient reaction process and precise purification technology ensure high product quality.
There are also many manufacturers of such compounds abroad. Some European and American chemical giants, with their deep technical accumulation and extensive R & D investment, occupy an important position in the global market. They not only have advanced production equipment, but also pay more attention to the concept of green chemistry, and strive to produce environmentally friendly and sustainable processes.
However, if you want to know exactly all the manufacturers, you need to check the chemical industry directory, academic literature and various industry exhibition materials in detail. Due to the rapid development of the chemical industry, new manufacturers may continue to emerge, and old manufacturers may withdraw from the market for various reasons. Therefore, only by searching all parties can you know the full picture of the manufacturers producing 6-methoxy-1,3-benzothiazole-2-carboxylic acid.