5 Trifluoromethyl 1 3 Thiazole 4 Carboxylic Acid
quinoline thiophene imidazole thiazole

5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid

    Specifications

    HS Code

    787590

    Name 5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid
    Molecular Formula C5H2F3NO2S
    Molecular Weight 199.13
    Appearance Solid (likely white or off - white)
    Physical State At Room Temperature Solid
    Melting Point Data may vary, typical organic solid range
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO
    Pka Data may vary, acidic due to carboxylic acid group

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    General Information
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    Frequently Asked Questions

    As a leading 5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 5- (trifluoromethyl) -1,3-thiazole-4-carboxylic acid?
    5- (trichloromethyl) -1,3-pentadiene-4-heptanoic acid is also an organic compound. This compound has many chemical properties.
    Its carbon-containing double bond, so it has the typical properties of olefins. Addition reaction can occur. When encountering bromine water, the elemental substance of bromine can be added to the carbon-carbon double bond, causing the bromine water to fade. This is because the carbon-carbon double bond has a high electron cloud density and has an attractive effect on electrophilic reagents. Bromine molecules are polarized by the double bond electron cloud, and then addition occurs. If added to hydrogen bromide, following the Markov rule, hydrogen atoms are added to the double bond carbon atoms containing more hydrogen to form specific halogenated hydrocarbon products. < Br >
    Its carboxyl group properties are also significant. It is acidic and can neutralize with bases, such as reacting with sodium hydroxide to form corresponding carboxylic salts and water. This is because the carboxyl group can ionize hydrogen ions. And it can undergo esterification reaction with alcohols. Under the catalysis of concentrated sulfuric acid and heating conditions, it can form esters and water with alcohols. This process is a reversible reaction. Concentrated sulfuric acid has the effect of both a catalyst and a water-absorbing agent, promoting the balance to move in the direction of ester formation.
    In addition, the chloromethyl part of the molecule has a large electronegativity of chlorine atoms, which reduces the density of methyl electron clouds, so that this part has unique activity in some reactions and can undergo substitution reactions. For example, under appropriate conditions, chlorine atoms can be replaced by other nucleophiles. Overall, this compound exhibits rich and diverse chemical properties due to the interaction of the functional groups it contains.
    What are the preparation methods of 5- (trifluoromethyl) -1,3-thiazole-4-carboxylic acid?
    To prepare 5- (trimethylphenyl) -1,3-pentadiene-4-heptanoic acid, there are several methods:
    First, the corresponding halogenated hydrocarbons and compounds containing active hydrogen can be used to gradually build the carbon chain according to the method of nucleophilic substitution. First, take a suitable halogenated trimethylphenyl group, and a compound containing pentadiene structure with a replaceable group, in a suitable solvent, under the catalysis of a base, to promote the nucleophilic substitution reaction. This process requires attention to the precise control of the reaction conditions and the appropriate selection of solvents, such as the use of polar aprotic solvents, which can improve the reaction rate and selectivity. The strength of the base also needs to be considered. If it is too strong, it will easily cause side reactions, and if it is too weak, it will be difficult to advance the reaction.
    Second, the addition reaction of carbon-carbon double bonds can be used. First, unsaturated compounds containing trimethylphenyl groups are prepared, and unsaturated substances containing pentadiene and carboxyl precursors are added in the presence of catalysts. It is crucial to choose the right catalyst, such as metal-organic catalysts, which can effectively improve the activity and stereoselectivity of the reaction. At the same time, the reaction temperature, pressure and other conditions also need to be carefully adjusted to obtain the ideal product.
    Third, through the conversion of carboxylic acid derivatives. First, carboxylic acid derivatives containing trimethylphenyl and pentadiene structures, such as esters, are prepared. Then, the ester group is converted into a carboxyl group by hydrolysis, acidification and other steps to obtain the target product. During this process, the hydrolysis conditions need to be carefully controlled, and factors such as the concentration of acid or base, reaction time, etc. have a significant impact on the purity and yield of the product.
    The above methods have advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty in controlling reaction conditions, and purity requirements of the product, and choose the appropriate preparation method.
    In which fields is 5- (trifluoromethyl) -1,3-thiazole-4-carboxylic acid used?
    5- (trimethyl) -1,3-butadiene-4-pentenoic acid has important applications in many fields.
    In the field of organic synthesis, this compound is a key synthesis intermediate. Due to its unique molecular structure, including active groups such as conjugated double bonds and carboxyl groups, various complex organic compounds can be constructed through a series of organic reactions, such as addition reactions, esterification reactions, etc. For example, when synthesizing natural product analogs with specific biological activities, its conjugated double bonds can be used for Diels-Alder reaction to effectively build a six-membered ring structure, which lays the foundation for subsequent modification and functionalization, and facilitates new drug development or material synthesis.
    In the field of polymer materials, 5- (trimethyl) -1,3-butadiene-4-pentenoic acid can participate in the polymerization reaction as a monomer. With the polymerization activity of double bonds, copolymerization with other monomers can endow polymer materials with special properties. For example, copolymerization with monomers such as ethylene can change the flexibility, thermal stability and chemical stability of polymers, and prepare polymer materials suitable for different scenarios, such as packaging materials, engineering plastics, etc.
    In the field of pharmaceutical chemistry, its carboxyl group and double bond structure provide a diverse modification check point for drug design. By structurally modifying it, specific pharmacoactive groups can be connected to enhance the affinity and selectivity of drugs and targets. In the design of some anticancer drugs, such structures will be introduced to help their active groups bind specifically to tumor cell targets, improve drug efficacy and reduce damage to normal cells.
    In short, 5- (trimethyl) -1,3-butadiene-4-pentenoic acid plays an irreplaceable role in the fields of organic synthesis, polymer materials and medicinal chemistry with its unique structure, promoting sustainable development and innovation in various fields.
    What is the market price of 5- (trifluoromethyl) -1,3-thiazole-4-carboxylic acid?
    In today's world, there are many business roads, and it is not easy to know the market price of triene methyl-1,3-butadiene-4-pentenoic acid. However, according to various reasons, a little speculation can be made.
    Futriene methyl-1,3-butadiene-4-pentenoic acid is widely used in various fields of chemical industry. It is a key ability for the synthesis of exquisite raw materials, or for pharmaceutical research and development, material creation, etc. The change of its market price often depends on the state of supply and demand, the progress of technology, and the price of raw materials. < Br >
    From the perspective of supply and demand, if there are many people in the market who want it, but there are few products, the price will rise. If today's high-tech industry is booming, the demand for fine chemical raw materials is increasing day by day. If this acid is suitable for its needs, the supply is not enough, and the price will rise. On the contrary, if the supply exceeds the demand, the price will drop.
    The progress of the process is also the main reason. If there are new technologies in the world that make production convenient and the cost is greatly reduced, the price may drop. In the past, all kinds of chemical products were expensive and rare due to the difficulty of the process. After the technology was refined, the price fell due to mass production.
    The price of raw materials also affects the market price of this acid. If the raw materials required for its preparation are expensive and difficult to obtain, the cost of this acid will be high, and the price will also increase accordingly.
    As for the current market price of trienomethyl-1,3-butadiene-4-pentenoic acid, it is difficult to determine. The market is fickle, and various factors interact. To know the details, when observing the real-time market conditions of the chemical industry, you can visit experts, or you can get a rough idea of its price. In general, its price often fluctuates due to the above reasons, or at a certain moment, according to the market state, it appears to be rising, falling or stable.
    What are the upstream and downstream products of 5- (trifluoromethyl) -1,3-thiazole-4-carboxylic acid?
    The upstream and downstream products of 5- (Sanxiang methyl) -1,3-sandalwood-4-kotonic acid are actually the key to the industrial layout and raw material supply in the chemical industry.
    Upstream products provide the necessary starting materials and intermediate products for the synthesis of this compound. To obtain 5- (Sanxiang methyl) -1,3-sandalwood-4-kotonic acid, or specific organic halides, such as aromatic derivatives containing halogen atoms, introduce Sanxiang methyl groups through nucleophilic substitution and other reactions. The preparation of this halide often depends on the halogenation reaction of aromatic hydrocarbons, with suitable halogenating agents and under suitable reaction conditions, the precise positioning of halogen atoms can be achieved.
    Furthermore, aldehyde and ketone compounds can also be important upstream raw materials. Through classic organic reactions such as hydroxyl-aldehyde condensation, carbon-carbon double bonds are formed, which lays the foundation for the subsequent construction of molecular skeletons. Such aldehyde and ketone raw materials, or derived from the oxidation of corresponding alcohols, can be efficiently obtained with suitable oxidants.
    As for downstream products, 5- (Sanxiang methyl) -1,3-sandalwood-4-konoic acid can be used as a key intermediate to synthesize a variety of high-value-added fine chemicals due to its unique molecular structure. In the field of fragrances, through specific modifications and transformations, new fragrances with unique aromas can be prepared, adding luster to perfume, cosmetics and other industries.
    In medicinal chemistry, it may be used as a key fragment of drug molecules. It can be spliced with other active groups to develop new drugs. For example, for specific disease targets, the molecular structure designed to fit them is expected to become a lead compound with good pharmacological activity and contribute to human health after a series of chemical modifications and optimizations.
    In summary, the supply of upstream raw materials and downstream product development of 5- (Sanxiang methyl) -1,3-sandalwood-4-konoic acid is of great significance in many fields such as chemicals, fragrances, and pharmaceuticals, and is related to the extension and expansion of the industrial chain.