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What is the chemical structure of ethyl 2- [[ (1,1-dimethylethoxy) carbonyl] amino] -5-thiazole carboxylate
2-% 5B% 5B% 281% 2C1-dimethylethoxycarbonyl% 29 hydrazine% 5D acetyl% 5D-5-methoxytryptamine ethyl acetate The chemical structure of ethyl acetate is a relatively complex organic compound structure. The following is a detailed description of its structure based on a text similar to ancient texts.
In this compound, the main structure revolves around tryptamine. The tryptamine part is its core skeleton, and the methoxy group is connected at position 5. This methoxy group is like the side beam of a pavilion, which stabilizes and affects the properties of the whole.
And position 2 is connected with complex substituents. The first is -% 5B% 5B% 281% 2C1-dimethylethoxy carbonyl% 29 hydrazine% 5D acetyl% 5D group. Among them,% 281% 2C1-dimethylethoxy carbonyl% 29 is like a strong barrier, and the two methyl groups are like the wings of the barrier to enhance its stability. Ethoxy carbonyl is connected to the nitrogen atom through carbon-oxygen double bonds to form a connection with the whole. Hydrazine is like a bridge, connecting% 281% 2C1-dimethylethoxy carbonyl% 29 with acetyl groups. The carbonyl groups and methyl groups in the acetyl group give this part unique chemical activity.
Furthermore, 5-methoxytryptamine is partially connected to ethyl acetate, and the ester-based structure in ethyl acetate is like a flexible bond that connects the tryptamine body to the outside world, giving the compound specific solubility and reactivity in different environments. The entire compound structure, the parts are interdependent, and together build a unique chemical structure, which is like a delicate mechanism, and the components work together to show unique chemical properties and reactivity.
What are the main uses of ethyl 2- [[ (1,1-dimethylethoxy) carbonyl] amino] -5-thiazole carboxylate
2-% [ (1,1-dimethylacetoxy) carbonyl] -5-nitropyridineformamide, although not directly recorded in Tiangong Kaiwu, but based on the knowledge of pharmacy and technology recorded in various ancient books, its main uses are roughly as follows:
In the field of medicine, it may be used as a key intermediate for the synthesis of specific drugs. It is often recorded in ancient books that many medicinal ingredients can be skillfully synthesized to exert unique curative effects. For example, many herbal medicines can be made into a cure and save people through complex processing and synthesis. This compound may be due to its unique chemical structure, and it can be used to construct pharmacologically active drug molecules through specific reaction steps to fight certain diseases. < Br >
In chemical synthesis, it can serve as an important reaction raw material. Although ancient chemical industry was different from today, the basic synthesis concepts were the same. For example, alchemy pursued longevity but accumulated chemical knowledge. People know that different substances can be mixed and reacted to form new substances. This compound may participate in a variety of organic synthesis reactions. With the help of its functional group characteristics, more complex and functional chemical products can be constructed, such as fine chemicals used to make special properties such as dyes and fragrances.
From the perspective of materials science, it may be useful for the improvement of the properties of certain materials. In ancient times, special substances were often added to improve the properties of ceramics, metals and other materials. For example, when firing ceramics, specific minerals were added to make the texture more delicate and the color more gorgeous. This compound may be used in modern material synthesis to modify the electrical, optical, and mechanical properties of materials by combining with other substances to meet the specific needs of materials in different fields.
What is the synthesis method of 2- [[ (1,1-dimethylethoxy) carbonyl] amino] -5-thiazole carboxylate ethyl ester
To prepare 2 - [ [( 1,1 -dimethylethoxycarbonyl) amino] carbonyl] -5 -methoxybenzamide, the following ancient method can be used.
First take the appropriate starting material and react with the amino-containing compound with 1,1-dimethylethoxycarbonyl chloride. This step requires slowly adding 1,1-dimethylethoxycarbonyl chloride dropwise in a suitable solvent, such as dichloromethane, at a low temperature environment to ensure the controllability of the reaction. During the reaction, an appropriate amount of organic base, such as triethylamine, is added to neutralize the resulting acid and promote the reaction to the right. After the reaction is complete, after extraction, washing, drying and other steps, an intermediate product containing [ (1,1-dimethylethoxycarbonyl) amino] can be obtained.
Then, this intermediate product is reacted with a carboxyl-containing compound under the action of a condensing agent. Commonly used condensing agents such as dicyclohexylcarbodiimide (DCC) with 4-dimethylaminopyridine (DMAP) are reacted in a suitable solvent such as N, N-dimethylformamide (DMF). The reaction process needs to pay attention to the control of temperature and time. After the reaction is completed, the key intermediate of 2 - [ [( 1,1 -dimethylethoxycarbonyl) amino] carbonyl] can be obtained by separation and purification.
Finally, this key intermediate is reacted with 5-methoxybenzoic acid derivatives to form an amide bond. This step can be carried out under similar condensation conditions, or in the form of a more active acid chloride, with the amino-containing part. After the reaction, the impurities were removed by column chromatography, recrystallization and other purification methods to obtain pure 2 - [ [( 1,1 -dimethylethoxycarbonyl) amino] carbonyl] -5 -methoxybenzamide. Every step of the reaction requires careful operation and attention to the subtle changes in the reaction conditions in order to achieve the ideal purity and yield of the product.
What are the physicochemical properties of ethyl 2- [[ (1,1-dimethylethoxy) carbonyl] amino] -5-thiazole carboxylate
2 - [ [( 1,1-dimethylcarbamoxy) pyridine] carbamoyl] - 5-cyanopyridine carboxylate ethyl ester, which is a rather complex organic compound. Its physical and chemical properties are as follows:
###1. Physical properties
1. ** Appearance and properties **: It is often presented in solid form, and the specific appearance may vary depending on the purity and crystallization conditions. It is mostly white to light yellow powder or crystalline solid. This is the common color state of many organic compounds.
2. ** Melting point and boiling point **: Melting point, boiling point and other data will vary depending on the purity of the compound, the environmental pressure and other factors. However, the intermolecular forces include van der Waals forces, hydrogen bonds, etc., which cause the molecules to bond tightly, usually with a high melting point and boiling point. Generally speaking, the melting point of compounds containing such structures may be in the range of 100-200 ° C, and the boiling point may exceed 300 ° C, but the exact value needs to be accurately determined by experiments.
3. ** Solubility **: The compound contains a variety of polar groups, such as carbamoyl groups, cyanyl groups, etc., so that it may have some solubility in polar organic solvents, such as methanol, ethanol, dichloromethane, N, N-dimethylformamide (DMF) and other organic solvents, or can be moderately dissolved. In water, due to the existence of hydrophobic hydrocarbon groups, the solubility may be poor.
###II. Chemical properties
1. ** Stability **: At room temperature and pressure without the influence of special chemical reagents, light, high temperature and other conditions, the chemical properties are relatively stable. However, because the molecule contains active functional groups such as cyanyl and ester groups, under specific conditions, or chemical reactions occur.
2. ** Functional group reaction **:
- ** Cyanyl reaction **: The cyanyl group can undergo hydrolysis reaction, and under the catalysis of acid or base, it is gradually converted into carboxyl or amide groups. Under acidic conditions, the cyanyl group is hydrolyzed to amide, and then hydrolyzed to carboxylic acid; under alkaline conditions, it is hydrolyzed to form carboxylate and ammonia. < Br > - ** Esteryl reaction **: prone to hydrolysis, hydrolysis under acidic conditions to form carboxylic acids and alcohols, and hydrolysis under alkaline conditions (saponification reaction) to form carboxylic salts and alcohols. At the same time, ester groups can participate in the transesterification reaction, exchanging parts of alcohols with different alcohols under the action of catalysts to form new esters.
- ** Pyridine ring reaction **: Pyridine rings are aromatic and can undergo electrophilic substitution reactions. Due to the electronegativity of nitrogen atoms, the reaction activity is different from that of benzene rings. The substitution check point is mainly at the β position (3-position) of the pyridine ring. In addition, the nitrogen atom of the pyridine ring can form coordination compounds with metal ions.
What is the market price range for ethyl 2- [[ (1,1-dimethylethoxy) carbonyl] amino] -5-thiazole carboxylate?
Today there are 2 - [ [ ( 1,1 -dimethylethoxy) carbonyl] oxy] - 5 -cyanopyridine ethyl acetate, what is the price range in the market?
My view of "Tiangong Kaiwu", which records all kinds of products and techniques in detail, but this product has not been directly stated. In today's world, the price of chemical products is often tied to multiple ends.
First, the price of raw materials. The raw material of this compound, if it is easy and abundant, its price is cheap; if the raw material is rare and difficult to find, the price will be high.
Second, the difficulty of preparation. If the preparation method is complicated, requires many steps and special equipment, reagents, and consumes manpower, material resources, and financial resources, the price is also high; if the preparation method is simple, the cost will be reduced and the price will be lower or lower.
Third, the demand of the market. If the product is in strong demand in the fields of medicine, chemical industry, etc., the supply is in short supply, and the price will rise; if the demand is small, the price may decline.
Fourth, the rules of production. Large-scale production, due to the scale effect, the cost may decrease, and the price may also be low; small-scale production, the cost is high and the price may be high.
According to my speculation, if there are no special circumstances, the market price of such fine chemicals may be between tens and hundreds of yuan per gram. However, this is only a rough estimate, and the actual price depends on the specific market conditions and quality specifications.