4-Thiazolecarboxylicacid,2-amino-5-chloro-,ethylester(9CI)

2-%E6%B0%A8%E5%9F%BA-5-%E6%B0%AF-4-%E5%99%BB%E5%94%91%E7%BE%A7%E9%85%B8%E4%B9%99%E9%85%AF (9CI), it is a class of organic compounds. Its physical properties have several characteristics, as detailed below:
Under normal temperature and pressure, most of them are liquid, but a few can be solid under specific conditions. Its color is often almost colorless, or only slightly light, just like the clarity of water, rarely strong color.
When it comes to smell, it often emits a special fragrance, but this fragrance is not a single smell, but has a unique charm, which is different from ordinary fragrance. However, some smells are slightly pungent, which varies according to its specific structure and composition.
As for the density, compared to water, most of these compounds have a slightly lower density, like a canoe on the lake surface, which can float on the water.
In terms of solubility, the solubility in water is low, just like the difficulty of oil and water. However, in organic solvents, such as ethanol, ether, etc., it shows good solubility and can be mutually soluble with it, just like water emulsion.
Boiling point and melting point are also important physical properties. The boiling point is usually within a certain range, neither very high nor very low, and varies according to the strength of the intermolecular force. The melting point also has corresponding characteristics. The melting point of this type of compound with different structures varies significantly, which is determined by the complexity of its molecular structure.
In addition, its volatility is also worthy of attention. Some of these compounds have a certain degree of volatility and can evaporate slowly in the air, such as the gradual dissipation of mist. This property also affects their application and storage.
This physical property plays an important role in the application of chemical industry, medicine and many other fields, laying the foundation for their effectiveness and realization of specific purposes.

Ethyl 2-% hydroxy-5-bromo-4-pyridinecarboxyacetate (9CI) is an organic compound with the following chemical properties:
1. ** Acidic **: The hydrogen atom in the hydroxyl group in its molecule, due to the strong electronegativity of the oxygen atom, is highly attractive to the hydrogen atom, so that the hydrogen atom is easily dissociated in the form of protons, showing a certain acidity. In the presence of appropriate bases, acid-base neutralization reactions can occur to generate corresponding salts.
2. ** Nucleophilic Substitution Reaction **: The bromine atom, as an important functional group of this compound, is extremely active. Due to the large electronegativity of the bromine atom, the carbon-bromine bond connected to the carbon atom has a strong polarity, which makes the carbon atom partially positively charged and vulnerable to attack by nucleophilic reagents. In case of nucleophilic reagents such as hydroxyl negative ions and amino negative ions, the bromine atom can be replaced to form new organic compounds, thereby introducing different functional groups to expand its chemical synthesis path.
3. ** Hydrolysis of ester groups **: The ester groups contained in this substance are prone to hydrolysis under acid or base catalysis conditions. Under acidic conditions, hydrolysis produces carboxylic acids and alcohols; under alkaline conditions, hydrolysis produces carboxylate and alcohols. Taking sodium hydroxide solution as an example, during basic hydrolysis, the carbonyl carbon in the ester group is attacked by the nucleophilic attack of the hydroxide ion, followed by a series of electron transfer, and finally forms the sodium carboxylate and ethanol.
4. ** Reactivity of the pyridine ring **: The pyridine ring is aromatic, and the electron cloud on the ring is unevenly distributed. The electronegativity of the nitrogen atom is greater than that of the carbon atom, which causes the electron cloud density of the carbon atom adjacent to the nitrogen atom on the pyridine ring to be relatively low, which is prone to electrophilic substitution reaction. The electrophilic reagents are more inclined to attack these check points with low electron cloud density. At the same time, the lone pair electrons on the nitrogen atom of the pyridine ring can coordinate with metal ions to form complexes, giving the compound

Ethyl 2-% hydroxy-5-bromo-4-pyridinecarboxyacetate (9CI) is an organic compound with important uses in many fields.
In the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its specific chemical structure, it can be modified and transformed by various chemical reactions to construct drug molecules with specific pharmacological activities. For example, by functionalizing different check points in its structure, new drugs targeting specific disease targets can be developed, such as anti-tumor and antiviral drugs. It may play a key role in the creation of drugs, providing pharmaceutical chemists with a promising starting material to help them design and synthesize more efficient and low-toxicity innovative drugs.
In the field of organic synthetic chemistry, 2-% hydroxy-5-bromo-4-pyridineacetoacetate (9CI) is also an important synthetic building block. Organic chemists can use its active functional groups to carry out a series of organic reactions such as nucleophilic substitution, esterification, cyclization, etc., to build a complex and diverse organic molecular skeleton. These complex organic molecules are either important intermediates in the total synthesis of natural products, or precursors of special functional materials required in the field of materials science, providing a rich structural basis and reaction possibilities for the development of organic synthetic chemistry.
In the field of materials science, specific derivatives synthesized based on this compound may exhibit unique optical, electrical or thermal properties. For example, through rational molecular design and modification, it is possible to prepare materials with specific fluorescence emission characteristics, which can be applied to optoelectronic devices such as fluorescence sensors and Light Emitting Diodes, thus expanding their application prospects in the research and development of new functional materials.

To prepare 2-amino-5-bromo-4-chlorobenzoate ethyl ester (9CI), there are several methods as follows.
First, the corresponding benzoic acid is used as the starting material. Halogen atoms are introduced at specific positions in the benzene ring of benzoic acid, which can be achieved by electrophilic substitution reaction. If you want to introduce bromine and chlorine atoms, you can choose suitable halogenating reagents, such as liquid bromine can undergo bromination reaction at specific positions in the benzene ring under the catalysis of catalysts such as iron filings; chlorine gas and suitable catalysts can be used for chlorination reaction. After the successful introduction of bromine and chlorine, the carboxyl group is converted into ethyl ester group, which can be achieved by esterification reaction of ethanol and acid catalyzed by concentrated sulfuric acid and heated. After that, the amino group is introduced at a suitable position in the benzene ring by a specific method, such as by means of nitro reduction method, the nitro group is first introduced, and then the nitro group is reduced to an amino group by reducing agents such as iron powder and hydrochloric acid.
Second, it is also possible to start from compounds with some target substituents. For example, select a compound with some halogen substituents on the benzene ring, and first perform functional group conversion to convert a functional group into an active group that can be further reacted to introduce other groups. Then, according to the reaction mechanism and conditions, the remaining required substituents are gradually introduced, such as first converting the existing group into an active intermediate that can react with ammonia or amino-containing reagents, so as to introduce an amino group; then esterifying the carboxyl group to obtain an ethyl ester group through a suitable reaction.
Third, the coupling reaction strategy can also be considered. Select halogen-containing benzene ring derivatives and carboxyl groups and compounds that can be used for coupling reactive groups, and connect the two parts through suitable coupling reaction conditions, such as palladium-catalyzed coupling reaction. Then the formed product is further modified, such as the introduction of amino groups and the conversion of carboxyl groups to ethyl ester groups, to achieve the synthesis of the target product 2-amino-5-bromo-4-chlorobenzoate ethyl ester.

2-Amino-5-bromo-4-chlorobenzoate ethyl ester (9CI) is an important compound in organic chemistry. During storage and transportation, many points need to be paid attention to.
When storing, the temperature and humidity of the first environment are the most important. This compound should be stored in a cool and dry place to prevent it from being hydrolyzed by moisture due to high humidity, and if the temperature is too high, it may cause adverse reactions such as thermal decomposition, which will damage its quality. And it must be stored separately from oxidizing agents, acids, bases, etc. Due to its active chemical properties, contact with them may easily cause chemical reactions, or even cause dangerous accidents. Furthermore, the storage place should be well ventilated to disperse possible harmful gases and ensure the safety of the storage environment.
As for the transportation process, the packaging must be strong and tight. Suitable packaging materials, such as corrosion-resistant containers, need to be selected to ensure that the compound does not leak during transportation. The transportation vehicle is also selected with corresponding qualifications, and its internal environment should be able to meet the requirements of the compound for temperature and humidity and other conditions. Transport personnel must be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and properly in case of emergencies. In particular, the loading and unloading process must be handled with caution, light loading and light handling, to avoid violent vibration and impact, so as to prevent the leakage of the compound due to package damage, endangering the safety of personnel and the environment. Therefore, Fangbao 2-amino-5-bromo-4-chlorobenzoate ethyl ester (9CI) is safe during storage and transportation.